The Framingham Heart Study
Research Milestones
1960 Cigarette smoking found to increase the risk of heart disease
1961 Cholesterol level, blood pressure, and electrocardiogram abnormalities found to increase the risk of heart disease
1967 Physical activity found to reduce the risk of heart disease and obesity to increase the risk of heart disease
1970 High blood pressure found to increase the risk of stroke
1976 Menopause found to increase the risk of heart disease
1978 Psychosocial factors found to affect heart disease
1988 High levels of HDL cholesterol found to reduce risk of death
1994 Enlarged left ventricle (one of two lower chambers of the heart) shown to increase the risk of stroke
1996 Progression from hypertension to heart failure described
1998 Development of simple coronary disease prediction algorithm involving risk factor categories to allow physicians to predict multivariate coronary heart disease risk in patients without overt CHD
1999 Lifetime risk at age 40 years of developing coronary heart disease is one in two for men and one in three for women
2001 High-normal blood pressure is associated with an increased risk of cardiovascular disease, emphasizing the need to determine whether lowering high-normal blood pressure can reduce the risk of cardiovascular disease.
2002 Lifetime risk of developing high blood pressure in middle-aged adults is 9 in 10.
2002 Obesity is a risk factor for heart failure.
2004 Serum aldosterone levels predict future risk of hypertension in non-hypertensive individuals.
2005 Lifetime risk of becoming overweight exceeds 70 percent, that for obesity approximates 1 in 2.
2006 The National Heart, Lung and Blood Institute (NHLBI) of the National Institutes of Health announces a new genome-wide association study at the Framingham Heart Study in collaboration with Boston University School of Medicine to be known as the SHARe project (SNP Health Association Resource).
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