Framingham Heart Study Bibliography
2009

Benjamin EJ, Rice KM, Arking DE, Pfeufer A, van Noord C, Smith AV, Schnabel RB, Bis JC, Boerwinkle E, Sinner MF, Dehghan A, Lubitz SA, D'Agostino RB Sr, Lumley T, Ehret GB, Heeringa J, Aspelund T, Newton-Cheh C, Larson MG, Marciante KD, Soliman EZ, Rivadeneira F, Wang TJ, EirÃ-ksdottir G, Levy D, Psaty BM, Li M, Chamberlain AM, Hofman A, Vasan RS, Harris TB, Rotter JI, Kao WH, Agarwal SK, Stricker BH, Wang K, Launer LJ, Smith NL, Chakravarti A, Uitterlinden AG, Wolf PA, Sotoodehnia N, Köttgen A, van Duijn CM, Meitinger T, Mueller M, Perz S, Steinbeck G, Wichmann HE, Lunetta KL, Heckbert SR, Gudnason V, Alonso A, Kääb S, Ellinor PT, Witteman JC. Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet. 2009 Aug;41(8):879-81. Epub 2009 Jul 13. (PubMed ID Number: 19597492 PMCID:PMC2761746).

Boger RH, Sullivan LM, Schwedhelm E, Wang TJ, Maas R, Benjamin EJ, Schulze F, Xanthakis V, Benndorf RA, Vasan RS: Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community. Circulation 2009;119:1592-1600. (PubMed ID Number: 19289633 PMCID: PMC2742491).

Chami HA, Keyes MJ, Vita JA, Mitchell GF, Larson MG, Fan S, Vasan RS, O'Connor GT, Benjamin EJ, Gottlieb DJ: Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing. Vasc Med 2009;14:351-360. (PubMed ID Number: 19808720 PMCID: PMC2956304)..

Chen TH, Gona P, Sutherland PA, Benjamin EJ, Wilson PW, Larson MG, Vasan RS, Robins SJ: Long-term C-reactive protein variability and prediction of metabolic risk. Am J Med 2009;122:53-61. (PubMed ID Number: 19114172 PMCID: PMC2654380).

Cheng S, Keyes MJ, Larson MG, McCabe EL, Newton-Cheh C, Levy D, Benjamin EJ, Vasan RS, Wang TJ: Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block. JAMA 2009;301:2571-2577. (PubMed ID Number: 19549974 PMCID: PMC2765917).

Debette S, Wolf PA, Beiser A, Au R, Himali JJ, Pikula A, Auerbach S, DeCarli C, Seshadri S: Association of parental dementia with cognitive and brain MRI measures in middle-aged adults. Neurology 2009;73:2071-2078. (PubMed ID Number: 20007524 PMCID: PMC2790222).

Dehghan A, Yang Q, Peters A, Basu S, Bis JC, Rudnicka AR, Kavousi M, Chen MH, Baumert J, Lowe GD, McKnight B, Tang W, de MM, Larson MG, Eyhermendy S, McArdle WL, Lumley T, Pankow JS, Hofman A, Massaro JM, Rivadeneira F, Kolz M, Taylor KD, Van Duijn CM, Kathiresan S, Illig T, Aulchenko YS, Volcik KA, Johnson AD, Uitterlinden AG, Tofler GH, Gieger C, Psaty BM, Couper DJ, Boerwinkle E, Koenig W, O'Donnell CJ, Witteman JC, Strachan DP, Smith NL, Folsom AR: Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circ Cardiovasc Genet 2009;2:125-133. (PubMed ID Number: 20031576 PMCID: PMC2764985).

DeStefano AL, Seshadri S, Beiser A, Atwood LD, Massaro JM, Au R, Wolf PA, DeCarli C: Bivariate heritability of total and regional brain volumes: the Framingham Study. Alzheimer Dis Assoc Disord 2009;23:218-223. (PubMed ID Number: 19812462 PMCID: PMC2760008).

Dhingra R, Pencina MJ, Schrader P, Wang TJ, Levy D, Pencina K, Siwik DA, Colucci WS, Benjamin EJ, Vasan RS: Relations of matrix remodeling biomarkers to blood pressure progression and incidence of hypertension in the community. Circulation 2009;119:1101-1107. (PubMed ID Number: 19221217 PMCID: PMC2729705).

Diaz T, Pencina MJ, Benjamin EJ, Aragam J, Fuller DL, Pencina KM, Levy D, Vasan RS: Prevalence, clinical correlates, and prognosis of discrete upper septal thickening on echocardiography: the Framingham Heart Study. Echocardiography 2009;26:247-253. (PubMed ID Number: 19175779 PMCID: PMC2657181).

Dietrich M, Jacques PF, Pencina MJ, Lanier K, Keyes MJ, Kaur G, Wolf PA, D'Agostino RB, Vasan RS: Vitamin E supplement use and the incidence of cardiovascular disease and all-cause mortality in the Framingham Heart Study: Does the underlying health status play a role? Atherosclerosis 2009;205:549-553. (PubMed ID Number: 19195657 PMCID: PMC2717181).

Djousse L, Himali JJ, Beiser A, Kelly-Hayes M, Wolf PA: Apolipoprotein e, alcohol consumption, and risk of ischemic stroke: the Framingham Heart Study revisited. J Stroke Cerebrovasc Dis 2009;18:384-388. (PubMed ID Number: 19717024 PMCID: PMC2743951).

Dufour AB, Broe KE, Nguyen US, Gagnon DR, Hillstrom HJ, Walker AH, Kivell E, Hannan MT: Foot pain: is current or past shoewear a factor? Arthritis Rheum 2009;61:1352-1358. (PubMed ID Number: 19790125 PMCID: PMC2761974).

Dupuis J, Shi J, Manning AK, Benjamin EJ, Meigs JB, Cupples LA, Siegmund D: Mapping quantitative traits in unselected families: algorithms and examples. Genet Epidemiol 2009;33:617-627. (PubMed ID Number: 19278016 PMCID: PMC2766029).

Fang Y, Wang Y: Testing for familial aggregation of functional traits. Stat Med 2009;28:3611-3625. (PubMed ID Number: 19731232).

Fayfman M, Niu J, Zhang YQ, Felson DT, Sack B, Aliabadi P, Selhub J, Hunter DJ: The relation of plasma homocysteine to radiographic knee osteoarthritis. Osteoarthritis Cartilage 2009;17:766-771. (PubMed ID Number: 19073367 PMCID: PMC2758241).

Fernandez AB, Keyes MJ, Pencina M, D'Agostino R, O'Donnell CJ, Thompson PD: Relation of corneal arcus to cardiovascular disease (from the Framingham Heart Study data set). Am J Cardiol 2009;103:64-66. (PubMed ID Number: 19101231 PMCID: PMC2636700).

Fox CS, Gona P, Hoffmann U, Porter SA, Salton CJ, Massaro JM, Levy D, Larson MG, D'Agostino RB, Sr., O'Donnell CJ, Manning WJ: Pericardial fat, intrathoracic fat, and measures of left ventricular structure and function: the Framingham Heart Study. Circulation 2009;119:1586-1591. (PubMed ID Number: 19289634 PMCID: PMC2727456).

Fox CS, Hwang SJ, Massaro JM, Lieb K, Vasan RS, O'Donnell CJ, Hoffmann U: Relation of subcutaneous and visceral adipose tissue to coronary and abdominal aortic calcium (from the Framingham Heart Study). Am J Cardiol 2009;104:543-547. (PubMed ID Number: 19660609 PMCID: PMC2723724 ).

Frankel DS, Vasan RS, D'Agostino RB, Sr., Benjamin EJ, Levy D, Wang TJ, Meigs JB: Resistin, adiponectin, and risk of heart failure the Framingham offspring study. J Am Coll Cardiol 2009;53:754-762. (PubMed ID Number: 19245965 PMCID: PMC2676793 ).

Franklin SS, Lopez VA, Wong ND, Mitchell GF, Larson MG, Vasan RS, Levy D: Single versus combined blood pressure components and risk for cardiovascular disease: the Framingham Heart Study. Circulation 2009;119:243-250. (PubMed ID Number: 19118251).

Govindaraju DR, Larson MG, Yin X, Benjamin EJ, Rao MB, Vasan RS: Association between SNP heterozygosity and quantitative traits in the Framingham Heart Study. Ann Hum Genet 2009;73:465-473. (PubMed ID Number: 19523151).

Hamburg NM, Benjamin EJ: Assessment of endothelial function using digital pulse amplitude tonometry. Trends Cardiovasc Med. 2009 Jan;19(1):6-11. (PubMed ID Number: 19467447).

Heard-Costa NL, Zillikens MC, Monda KL, Johansson A, Harris TB, Fu M, Haritunians T, Feitosa MF, Aspelund T, Eiriksdottir G, Garcia M, Launer LJ, Smith AV, Mitchell BD, McArdle PF, Shuldiner AR, Bielinski SJ, Boerwinkle E, Brancati F, Demerath EW, Pankow JS, Arnold AM, Chen YD, Glazer NL, McKnight B, Psaty BM, Rotter JI, Amin N, Campbell H, Gyllensten U, Pattaro C, Pramstaller PP, Rudan I, Struchalin M, Vitart V, Gao X, Kraja A, Province MA, Zhang Q, Atwood LD, Dupuis J, Hirschhorn JN, Jaquish CE, O'Donnell CJ, Vasan RS, White CC, Aulchenko YS, Estrada K, Hofman A, Rivadeneira F, Uitterlinden AG, Witteman JC, Oostra BA, Kaplan RC, Gudnason V, O'Connell JR, Borecki IB, Van Duijn CM, Cupples LA, Fox CS, North KE: NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet 2009;5:e1000539. (PubMed ID Number: 19557197 PMCID: PMC2695005).

Hivert MF, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC: Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study. Diabetes 2009;58:750-756. (PubMed ID Number: 19074981 PMCID: PMC2646076).

Ikram MA, Seshadri S, Bis JC, Fornage M, DeStefano AL, Aulchenko YS, Debette S, Lumley T, Folsom AR, van den Herik EG, Bos MJ, Beiser A, Cushman M, Launer LJ, Shahar E, Struchalin M, Du Y, Glazer NL, Rosamond WD, Rivadeneira F, Kelly-Hayes M, Lopez OL, Coresh J, Hofman A, DeCarli C, Heckbert SR, Koudstaal PJ, Yang Q, Smith NL, Kase CS, Rice K, Haritunians T, Roks G, de Kort PL, Taylor KD, de Lau LM, Oostra BA, Uitterlinden AG, Rotter JI, Boerwinkle E, Psaty BM, Mosley TH, Van Duijn CM, Breteler MM, Longstreth WT, Jr., Wolf PA: Genomewide association studies of stroke. N Engl J Med 2009;360:1718-1728. (PubMed ID Number: 19369658 PMCID: PMC2768348).

Imamura F, Lichtenstein AH, Dallal GE, Meigs JB, Jacques PF: Confounding by dietary patterns of the inverse association between alcohol consumption and type 2 diabetes risk. Am J Epidemiol 2009;170:37-45. (PubMed ID Number: 19429876 PMCID: PMC2733040).

Imamura F, Lichtenstein AH, Dallal GE, Meigs JB, Jacques PF: Generalizability of dietary patterns associated with incidence of type 2 diabetes mellitus. Am J Clin Nutr 2009;90:1075-1083. (PubMed ID Number: 19710193 PMCID: PMC2744626).

Ingelsson E, Massaro JM, Sutherland P, Jacques PF, Levy D, D'Agostino RB, Vasan RS, Robins SJ: Contemporary trends in dyslipidemia in the Framingham Heart Study. Arch Intern Med 2009;169:279-286. (PubMed ID Number: 19204219).

Jain SH, Massaro JM, Hoffmann U, Rosito GA, Vasan RS, Raji A, O'Donnell CJ, Meigs JB, Fox CS: Cross-sectional associations between abdominal and thoracic adipose tissue compartments and adiponectin and resistin in the Framingham Heart Study. Diabetes Care 2009;32:903-908. (PubMed ID Number: 19223612 PMCID: PMC2671095).

Johnson AD, Kavousi M, Smith AV, Chen MH, Dehghan A, Aspelund T, Lin JP, Van Duijn CM, Harris TB, Cupples LA, Uitterlinden AG, Launer L, Hofman A, Rivadeneira F, Stricker B, Yang Q, O'Donnell CJ, Gudnason V, Witteman JC: Genome-wide association meta-analysis for total serum bilirubin levels. Hum Mol Genet 2009;18:2700-2710. (PubMed ID Number: 19414484 PMCID: PMC2701336).

Johnson AD, O'Donnell CJ: An open access database of genome-wide association results. BMC Med Genet 2009;10:6. (PubMed ID Number: 19161620 PMCID: PMC2639349).

Joseph J, Pencina MJ, Wang TJ, Hayes L, Tofler GH, Jacques P, Selhub J, Levy D, D'Agostino RB, Sr., Benjamin EJ, Vasan RS: Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community. J Hypertens 2009;27:1317-1324. (PubMed ID Number: 19357531 PMCID: PMC2688088).

Kaab S, Darbar D, van NC, Dupuis J, Pfeufer A, Newton-Cheh C, Schnabel R, Makino S, Sinner MF, Kannankeril PJ, Beckmann BM, Choudry S, Donahue BS, Heeringa J, Perz S, Lunetta KL, Larson MG, Levy D, MacRae CA, Ruskin JN, Wacker A, Schomig A, Wichmann HE, Steinbeck G, Meitinger T, Uitterlinden AG, Witteman JC, Roden DM, Benjamin EJ, Ellinor PT: Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation. Eur Heart J 2009;30:813-819. (PubMed ID Number: 19141561 PMCID: PMC2663727).

Kalichman L, Cole R, Kim DH, Li L, Suri P, Guermazi A, Hunter DJ: Spinal stenosis prevalence and association with symptoms: the Framingham Study. Spine J 2009;9:545-550. (PubMed ID Number: 19398386).

Kalichman L, Kim DH, Li L, Guermazi A, Berkin V, Hunter DJ: Spondylolysis and spondylolisthesis: prevalence and association with low back pain in the adult community-based population. Spine (Phila Pa 1976 ) 2009;34:199-205. (PubMed ID Number: 19139672).

Kalichman L, Suri P, Guermazi A, Li L, Hunter DJ: Facet orientation and tropism: associations with facet joint osteoarthritis and degeneratives. Spine (Phila Pa 1976 ) 2009;34:E579-E585. (PubMed ID Number: 19770601).

Kannel WB: Hypertension: reflections on risks and prognostication. Med Clin North Am 2009;93:541-58, Table. (PubMed ID Number: 19427490).

Kannel WB, Vasan RS: Is age really a non-modifiable cardiovascular risk factor? Am J Cardiol 2009;104:1307-1310. (PubMed ID Number: 19840582).

Kannel WB, Vasan RS: Adverse consequences of the 50% misconception. Am J Cardiol 2009;103:426-427. (PubMed ID Number: 19166702).

Kannel WB, Vasan RS: Triglycerides as vascular risk factors: new epidemiologic insights. Curr Opin Cardiol 2009;24:345-350. (PubMed ID Number: 19424059 PMCID: PMC3012388).

Kannel WB, Benjamin EJ: Current perceptions of the epidemiology of atrial fibrillation. Cardiol Clin 2009;27:13-24, vii. (PubMed ID Number: 19111760 PMCID: PMC2917063).

Karasik D, Zhou Y, Cupples LA, Hannan MT, Kiel DP, Demissie S: Bivariate genome-wide linkage analysis of femoral bone traits and leg lean mass: Framingham study. J Bone Miner Res 2009;24:710-718. (PubMed ID Number: 19063671 PMCID: PMC2659513).

Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T, Voight BF, Bonnycastle LL, Jackson AU, Crawford G, Surti A, Guiducci C, Burtt NP, Parish S, Clarke R, Zelenika D, Kubalanza KA, Morken MA, Scott LJ, Stringham HM, Galan P, Swift AJ, Kuusisto J, Bergman RN, Sundvall J, Laakso M, Ferrucci L, Scheet P, Sanna S, Uda M, Yang Q, Lunetta KL, Dupuis J, de Bakker PI, O'Donnell CJ, Chambers JC, Kooner JS, Hercberg S, Meneton P, Lakatta EG, Scuteri A, Schlessinger D, Tuomilehto J, Collins FS, Groop L, Altshuler D, Collins R, Lathrop GM, Melander O, Salomaa V, Peltonen L, Orho-Melander M, Ordovas JM, Boehnke M, Abecasis GR, Mohlke KL, Cupples LA: Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 2009;41:56-65. (PubMed ID Number: 19060906 PMCID: PMC2685478).

Kelley-Hedgepeth A, Peter I, Montefusco MC, Levy D, Benjamin EJ, Vasan RS, Mendelsohn ME, Housman D, Huggins GS, Mitchell GF: The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort. J Hypertens 2009;27:55-60. (PubMed ID Number: 19050450 PMCID: PMC2637763).

Kenchaiah S, Benjamin EJ, Evans JC, Aragam J, Vasan RS: Epidemiology of left ventricular false tendons: clinical correlates in the Framingham Heart Study. J Am Soc Echocardiogr 2009;22:739-745. (PubMed ID Number: 19423290 PMCID: PMC2722746).

Kottgen A, Glazer NL, Dehghan A, Hwang SJ, Katz R, Li M, Yang Q, Gudnason V, Launer LJ, Harris TB, Smith AV, Arking DE, Astor BC, Boerwinkle E, Ehret GB, Ruczinski I, Scharpf RB, Ida Chen YD, de Boer IH, Haritunians T, Lumley T, Sarnak M, Siscovick D, Benjamin EJ, Levy D, Upadhyay A, Aulchenko YS, Hofman A, Rivadeneira F, Uitterlinden AG, Van Duijn CM, Chasman DI, Pare G, Ridker PM, Kao WH, Witteman JC, Coresh J, Shlipak MG, Fox CS: Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet 2009. (PubMed ID Number: 19430482).

Lee DS, Gona P, Vasan RS, Larson MG, Benjamin EJ, Wang TJ, Tu JV, Levy D: Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the framingham heart study of the national heart, lung, and blood institute. Circulation 2009;119:3070-3077. (PubMed ID Number: 19506115 PMCID: PMC2775498).

Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, Aulchenko Y, Lumley T, Kottgen A, Vasan RS, Rivadeneira F, Eiriksdottir G, Guo X, Arking DE, Mitchell GF, Mattace-Raso FU, Smith AV, Taylor K, Scharpf RB, Hwang SJ, Sijbrands EJ, Bis J, Harris TB, Ganesh SK, O'Donnell CJ, Hofman A, Rotter JI, Coresh J, Benjamin EJ, Uitterlinden AG, Heiss G, Fox CS, Witteman JC, Boerwinkle E, Wang TJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, Van Duijn CM: Genome-wide association study of blood pressure and hypertension. Nat Genet 2009. (PubMed ID Number: 19430479).

Lieb W, Manning AK, Florez JC, Dupuis J, Cupples LA, McAteer JB, Vasan RS, Hoffmann U, O'Donnell CJ, Meigs JB, Fox CS: Variants in the CNR1 and the FAAH genes and adiposity traits in the community. Obesity (Silver Spring) 2009;17:755-760. (PubMed ID Number: 19165169).

Lieb W, Sullivan LM, Harris TB, Roubenoff R, Benjamin EJ, Levy D, Fox CS, Wang TJ, Wilson PW, Kannel WB, Vasan RS: Plasma leptin levels and incidence of heart failure, cardiovascular disease, and total mortality in elderly individuals. Diabetes Care 2009;32:612-616. (PubMed ID Number: 19114611 PMCID: PMC2660448).

Lieb W, Xanthakis V, Sullivan LM, Aragam J, Pencina MJ, Larson MG, Benjamin EJ, Vasan RS: Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the framingham offspring study. Circulation 2009;119:3085-3092. (PubMed ID Number: 19506113 PMCID: PMC2761217).

Lieb W, Sullivan LM, Aragam J, Harris TB, Roubenoff R, Benjamin EJ, Vasan RS: Relation of serum leptin with cardiac mass and left atrial dimension in individuals >70 years of age. Am J Cardiol 2009;104:602-605. (PubMed ID Number: 19660619 PMCID: PMC2745631).

Lieb W, Larson MG, Benjamin EJ, Yin X, Tofler GH, Selhub J, Jacques PF, Wang TJ, Vita JA, Levy D, Vasan RS, Mitchell GF: Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study. Circulation 2009;119:37-43. (PubMed ID Number: 19103986 PMCID: PMC2722113).

Lieb W, Benndorf RA, Benjamin EJ, Sullivan LM, Maas R, Xanthakis V, Schwedhelm E, Aragam J, Schulze F, Boger RH, Vasan RS: Plasma asymmetric dimethylarginine, L-arginine and left ventricular structure and function in a community-based sample. Atherosclerosis 2009;204:282-287. (PubMed ID Number: 18829028 PMCID: PMC2714984).

Lieb W, Safa R, Benjamin EJ, Xanthakis V, Yin X, Sullivan LM, Larson MG, Smith HM, Vita JA, Mitchell GF, Sawyer DB, Vasan RS: Vascular endothelial growth factor, its soluble receptor, and hepatocyte growth factor: clinical and genetic correlates and association with vascular function. Eur Heart J 2009;30:1121-1127. (PubMed ID Number: 19223316 PMCID: PMC2721714).

Lieb W, Beiser AS, Vasan RS, Tan ZS, Au R, Harris TB, Roubenoff R, Auerbach S, DeCarli C, Wolf PA, Seshadri S: Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA 2009;302:2565-2572. (PubMed ID Number: 20009056 PMCID: PMC2838501).

Lieb W, Pencina MJ, Lanier KJ, Tofler GH, Levy D, Fox CS, Wang TJ, D'Agostino RB, Sr., Vasan RS: Association of parental obesity with concentrations of select systemic biomarkers in nonobese offspring: the Framingham Heart Study. Diabetes 2009;58:134-137. (PubMed ID Number: 18931036 PMCID: PMC2606861).

Lin JP, Schwaiger JP, Cupples LA, O'Donnell CJ, Zheng G, Schoenborn V, Hunt SC, Joo J, Kronenberg F: Conditional linkage and genome-wide association studies identify UGT1A1 as a major gene for anti-atherogenic serum bilirubin levels--the Framingham Heart Study. Atherosclerosis 2009;206:228-233. (PubMed ID Number: 19389676 PMCID: PMC2752659).

Lin JP, O'Donnell CJ, Fox CS, Cupples LA: Heritability of serum gamma-glutamyltransferase level: genetic analysis from the Framingham Offspring Study. Liver Int 2009;29:776-777. (PubMed ID Number: 19192172).

Lisabeth LD, Beiser AS, Brown DL, Murabito JM, Kelly-Hayes M, Wolf PA: Age at natural menopause and risk of ischemic stroke: the Framingham heart study. Stroke 2009;40:1044-1049. (PubMed ID Number: 19233935 PMCID: PMC2682709).

Liu C, Yang Q, Adrienne CL, Meigs JB, Dupuis J: Selection of the most informative individuals from families with multiple siblings for association studies. Genet Epidemiol 2009;33:299-307. (PubMed ID Number: 19025786).

Liu E, McKeown NM, Newby PK, Meigs JB, Vasan RS, Quatromoni PA, D'Agostino RB, Jacques PF: Cross-sectional association of dietary patterns with insulin-resistant phenotypes among adults without diabetes in the Framingham Offspring Study. Br J Nutr 2009;102:576-583. (PubMed ID Number: 19216828).

Liu E, Meigs JB, Pittas AG, McKeown NM, Economos CD, Booth SL, Jacques PF: Plasma 25-hydroxyvitamin d is associated with markers of the insulin resistant phenotype in nondiabetic adults. J Nutr 2009;139:329-334. (PubMed ID Number: 19106328 PMCID: PMC2646208).

Loucks EB, Lynch JW, Pilote L, Fuhrer R, Almeida ND, Richard H, Agha G, Murabito JM, Benjamin EJ: Life-course socioeconomic position and incidence of coronary heart disease: the Framingham Offspring Study. Am J Epidemiol 2009;169:829-836. (PubMed ID Number: 19179358 PMCID: PMC2727217).

Maas R, Xanthakis V, Polak JF, Schwedhelm E, Sullivan LM, Benndorf R, Schulze F, Vasan RS, Wolf PA, Boger RH, Seshadri S: Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the Framingham Heart Study offspring cohort. Stroke 2009;40:2715-2719. (PubMed ID Number: 19498184 PMCID: PMC2749947).

Magnani JW, Williamson MA, Ellinor PT, Monahan KM, Benjamin EJ: P wave indices: current status and future directions in epidemiology, clinical, and research applications. Circ Arrhythm Electrophysiol 2009;2:72-79. (PubMed ID Number: 19808445 PMCID: PMC2760837).

Mahabadi AA, Massaro JM, Rosito GA, Levy D, Murabito JM, Wolf PA, O'Donnell CJ, Fox CS, Hoffmann U: Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study. Eur Heart J 2009;30:850-856. (PubMed ID Number: 19136488).

Matthan NR, Pencina M, LaRocque JM, Jacques PF, D'Agostino RB, Schaefer EJ, Lichtenstein AH: Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD. J Lipid Res 2009;50:1927-1935. (PubMed ID Number: 19436064 PMCID: PMC2724787).

Molenaar EA, Massaro JM, Jacques PF, Pou KM, Ellison RC, Hoffmann U, Pencina K, Shadwick SD, Vasan RS, O'Donnell CJ, Fox CS: Association of lifestyle factors with abdominal subcutaneous and visceral adiposity: the Framingham Heart Study. Diabetes Care 2009;32:505-510. (PubMed ID Number: 19074991 PMCID: PMC2646037).

Murabito JM, Keyes MJ, Guo CY, Keaney JF, Jr., Vasan RS, D'Agostino RB, Sr., Benjamin EJ: Cross-sectional relations of multiple inflammatory biomarkers to peripheral arterial disease: The Framingham Offspring Study. Atherosclerosis 2009;203:509-514. (PubMed ID Number: 18701106 PMCID: PMC2690511).

Neogi T, Felson D, Niu J, Nevitt M, Lewis CE, Aliabadi P, Sack B, Torner J, Bradley L, Zhang Y: Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies. BMJ 2009;339:b2844. (PubMed ID Number: 19700505 PMCID: PMC2730438).

Newton-Cheh C, Eijgelsheim M, Rice KM, de Bakker PI, Yin X, Estrada K, Bis JC, Marciante K, Rivadeneira F, Noseworthy PA, Sotoodehnia N, Smith NL, Rotter JI, Kors JA, Witteman JC, Hofman A, Heckbert SR, O'Donnell CJ, Uitterlinden AG, Psaty BM, Lumley T, Larson MG, Stricker BH: Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet 2009;41:399-406. (PubMed ID Number: 19305408 PMCID: PMC2701449).

Nolte IM, Wallace C, Newhouse SJ, Waggott D, Fu J, Soranzo N, Gwilliam R, Deloukas P, Savelieva I, Zheng D, Dalageorgou C, Farrall M, Samani NJ, Connell J, Brown M, Dominiczak A, Lathrop M, Zeggini E, Wain LV, Newton-Cheh C, Eijgelsheim M, Rice K, de Bakker PI, Pfeufer A, Sanna S, Arking DE, Asselbergs FW, Spector TD, Carter ND, Jeffery S, Tobin M, Caulfield M, Snieder H, Paterson AD, Munroe PB, Jamshidi Y: Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. PLoS One 2009;4:e6138. (PubMed ID Number: 19587794 PMCID: PMC2704957).

Parikh NI, Gona P, Larson MG, Fox CS, Benjamin EJ, Murabito JM, O'Donnell CJ, Vasan RS, Levy D: Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study. Circulation 2009;119:1203-1210. (PubMed ID Number: 19237656 PMCID: PMC2725400).

Parikh NI, Hwang SJ, Ingelsson E, Benjamin EJ, Fox CS, Vasan RS, Murabito JM: Breastfeeding in infancy and adult cardiovascular disease risk factors. Am J Med 2009;122:656-663. (PubMed ID Number: 19559168 PMCID: PMC2704490).

Parikh NI, Keyes MJ, Larson MG, Pou KM, Hamburg NM, Vita JA, O'Donnell CJ, Vasan RS, Mitchell GF, Hoffmann U, Fox CS, Benjamin EJ: Visceral and subcutaneous adiposity and brachial artery vasodilator function. Obesity (Silver Spring) 2009;17:2054-2059. (PubMed ID Number: 19282819 PMC In-process).

Pencina MJ, D'Agostino RB, Sr., Larson MG, Massaro JM, Vasan RS: Predicting the 30-year risk of cardiovascular disease: the framingham heart study. Circulation 2009;119:3078-3084. (PubMed ID Number: 19506114 PMCID: PMC2748236).

Perry JR, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E, Cherkas L, Eiriksdottir G, Estrada K, Ferrucci L, Folsom AR, Garcia M, Gudnason V, Hofman A, Karasik D, Kiel DP, Launer LJ, van MJ, Nalls MA, Rivadeneira F, Shuldiner AR, Singleton A, Soranzo N, Tanaka T, Visser JA, Weedon MN, Wilson SG, Zhuang V, Streeten EA, Harris TB, Murray A, Spector TD, Demerath EW, Uitterlinden AG, Murabito JM: Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet 2009. (PubMed ID Number: 19448620 PMCID: PMC2942986).

Peter I, Kelley-Hedgepeth A, Huggins GS, Housman DE, Mendelsohn ME, Vita JA, Vasan RS, Levy D, Benjamin EJ, Mitchell GF: Association between arterial stiffness and variations in oestrogen-related genes. J Hum Hypertens 2009;23:636-644. (PubMed ID Number: 19194457 PMCID: PMC2746260).

Petrea RE, Beiser AS, Seshadri S, Kelly-Hayes M, Kase CS, Wolf PA: Gender differences in stroke incidence and poststroke disability in the Framingham heart study. Stroke 2009;40:1032-1037. (PubMed ID Number: 19211484 PMCID: PMC2676725).

Pikula A, Boger RH, Beiser AS, Maas R, DeCarli C, Schwedhelm E, Himali JJ, Schulze F, Au R, Kelly-Hayes M, Kase CS, Vasan RS, Wolf PA, Seshadri S: Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study. Stroke 2009;40:2959-2964. (PubMed ID Number: 19644064 PMCID: PMC2749945).

Porter SA, Massaro JM, Hoffmann U, Vasan RS, O'Donnel CJ, Fox CS: Abdominal subcutaneous adipose tissue: a protective fat depot? Diabetes Care 2009;32:1068-1075. (PubMed ID Number: 19244087 PMCID: PMC2681034).

Pou KM, Massaro JM, Hoffmann U, Lieb K, Vasan RS, O'Donnell CJ, Fox CS: Patterns of abdominal fat distribution: the Framingham Heart Study. Diabetes Care 2009;32:481-485. (PubMed ID Number: 19074995 PMCID: PMC2646033).

Preis SR, Pencina MJ, Hwang SJ, D'Agostino RB, Sr., Savage PJ, Levy D, Fox CS: Trends in cardiovascular disease risk factors in individuals with and without diabetes mellitus in the Framingham Heart Study. Circulation 2009;120:212-220. (PubMed ID Number: 19581493 PMCID: PMC2789428).

Preis SR, Hwang SJ, Coady S, Pencina MJ, D'Agostino RB, Sr., Savage PJ, Levy D, Fox CS: Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005. Circulation 2009;119:1728-1735. (PubMed ID Number: 19307472 PMCID: PMC2789419).

Preis SR, Hwang SJ, Fox CS, Massaro JM, Levy D, Hoffmann U, O'Donnell CJ: Eligibility of individuals with subclinical coronary artery calcium and intermediate coronary heart disease risk for reclassification (from the Framingham Heart Study). Am J Cardiol 2009;103:1710-1715. (PubMed ID Number: 19539080).

Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K, Beckmann JS, Bergman RN, Bochud M, Bonnycastle LL, Buchanan TA, Cao A, Cervino A, Coin L, Collins FS, Crisponi L, de Geus EJ, Dehghan A, Deloukas P, Doney AS, Elliott P, Freimer N, Gateva V, Herder C, Hofman A, Hughes TE, Hunt S, Illig T, Inouye M, Isomaa B, Johnson T, Kong A, Krestyaninova M, Kuusisto J, Laakso M, Lim N, Lindblad U, Lindgren CM, McCann OT, Mohlke KL, Morris AD, Naitza S, Orru M, Palmer CN, Pouta A, Randall J, Rathmann W, Saramies J, Scheet P, Scott LJ, Scuteri A, Sharp S, Sijbrands E, Smit JH, Song K, Steinthorsdottir V, Stringham HM, Tuomi T, Tuomilehto J, Uitterlinden AG, Voight BF, Waterworth D, Wichmann HE, Willemsen G, Witteman JC, Yuan X, Zhao JH, Zeggini E, Schlessinger D, Sandhu M, Boomsma DI, Uda M, Spector TD, Penninx BW, Altshuler D, Vollenweider P, Jarvelin MR, Lakatta E, Waeber G, Fox CS, Peltonen L, Groop LC, Mooser V, Cupples LA, Thorsteinsdottir U, Boehnke M, Barroso I, Van DC, Dupuis J, Watanabe RM, Stefansson K, McCarthy MI, Wareham NJ, Meigs JB, Abecasis GR: Variants in MTNR1B influence fasting glucose levels. Nat Genet 2009;41:77-81. (PubMed ID Number: 19060907 PMCID: PMC2682768).

Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJ, Perry JR, Tanaka T, Timpson NJ, Semple RK, Soranzo N, Song K, Rocha N, Grundberg E, Dupuis J, Florez JC, Langenberg C, Prokopenko I, Saxena R, Sladek R, Aulchenko Y, Evans D, Waeber G, Erdmann J, Burnett MS, Sattar N, Devaney J, Willenborg C, Hingorani A, Witteman JC, Vollenweider P, Glaser B, Hengstenberg C, Ferrucci L, Melzer D, Stark K, Deanfield J, Winogradow J, Grassl M, Hall AS, Egan JM, Thompson JR, Ricketts SL, Konig IR, Reinhard W, Grundy S, Wichmann HE, Barter P, Mahley R, Kesaniemi YA, Rader DJ, Reilly MP, Epstein SE, Stewart AF, Van Duijn CM, Schunkert H, Burling K, Deloukas P, Pastinen T, Samani NJ, McPherson R, Davey SG, Frayling TM, Wareham NJ, Meigs JB, Mooser V, Spector TD: A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet 2009;5:e1000768. (PubMed ID Number: 20011104 PMCID: PMC2781107).

Rivadeneira F, Styrkarsdottir U, Estrada K, Halldorsson BV, Hsu YH, Richards JB, Zillikens MC, Kavvoura FK, Amin N, Aulchenko YS, Cupples LA, Deloukas P, Demissie S, Grundberg E, Hofman A, Kong A, Karasik D, van Meurs JB, Oostra B, Pastinen T, Pols HA, Sigurdsson G, Soranzo N, Thorleifsson G, Thorsteinsdottir U, Williams FM, Wilson SG, Zhou Y, Ralston SH, Van Duijn CM, Spector T, Kiel DP, Stefansson K, Ioannidis JP, Uitterlinden AG: Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet 2009;41:1199-1206. (PubMed ID Number: 19801982 PMCID: PMC2783489).

Roemer FW, Guermazi A, Hunter DJ, Niu J, Zhang Y, Englund M, Javaid MK, Lynch JA, Mohr A, Torner J, Lewis CE, Nevitt MC, Felson DT: The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies. Osteoarthritis Cartilage 2009;17:748-753. (PubMed ID Number: 19008123 PMCID: PMC2740855).

Romero JR, Beiser A, Seshadri S, Benjamin EJ, Polak JF, Vasan RS, Au R, DeCarli C, Wolf PA: Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study. Stroke 2009;40:1590-1596. (PubMed ID Number: 19265054 PMCID: PMC2705324).

Romero JR, Vasan RS, Beiser AS, Au R, Benjamin EJ, DeCarli C, Wolf PA, Seshadri S: Association of matrix metalloproteinases with MRI indices of brain ischemia and aging. Neurobiol Aging 2009. (PubMed ID Number: 19128858 PMCID: PMC2891210).

Rumawas ME, Meigs JB, Dwyer JT, McKeown NM, Jacques PF: Mediterranean-style dietary pattern, reduced risk of metabolic syndrome traits, and incidence in the Framingham Offspring Cohort. Am J Clin Nutr 2009;90:1608-1614. (PubMed ID Number: 19828705).

Rumawas ME, Dwyer JT, McKeown NM, Meigs JB, Rogers G, Jacques PF: The development of the Mediterranean-style dietary pattern score and its application to the American diet in the Framingham Offspring Cohort. J Nutr 2009;139:1150-1156. (PubMed ID Number: 19357215 PMCID: PMC2682986).

Sahni S, Hannan MT, Gagnon D, Blumberg J, Cupples LA, Kiel DP, Tucker KL: Protective effect of total and supplemental vitamin C intake on the risk of hip fracture--a 17-year follow-up from the Framingham Osteoporosis Study. Osteoporos Int 2009;20:1853-1861. (PubMed ID Number: 19347239 PMCID: PMC2766028).

Sahni S, Hannan MT, Blumberg J, Cupples LA, Kiel DP, Tucker KL: Inverse association of carotenoid intakes with 4-y change in bone mineral density in elderly men and women: the Framingham Osteoporosis Study. Am J Clin Nutr 2009;89:416-424. (PubMed ID Number: 19056581).

Sahni S, Hannan MT, Blumberg J, Cupples LA, Kiel DP, Tucker KL: Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: a 17-year follow-up from the Framingham Osteoporosis Study. J Bone Miner Res 2009;24:1086-1094. (PubMed ID Number: 19138129 PMCID: PMC2683648).

Schlett CL, Massaro JM, Lehman SJ, Bamberg F, O'Donnell CJ, Fox CS, Hoffmann U: Novel measurements of periaortic adipose tissue in comparison to anthropometric measures of obesity, and abdominal adipose tissue. Int J Obes (Lond) 2009;33:226-232. (PubMed ID Number: 19139753).

Schnabel R, Dupuis J, Larson MG, Lunetta KL, Robins SJ, Zhu Y, Rong J, Yin X, Stirnadel HA, Nelson JJ, Wilson PW, Keaney JF, Vasan RS, Benjamin EJ: Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study. Atherosclerosis 2009;204:601-607. (PubMed ID Number: 19135199 PMCID: PMC2893025).

Schnabel RB, Larson MG, Yamamoto JF, Kathiresan S, Rong J, Levy D, Keaney JF, Jr., Wang TJ, Vasan RS, Benjamin EJ: Relation of multiple inflammatory biomarkers to incident atrial fibrillation. Am J Cardiol 2009;104:92-96. (PubMed ID Number: 19576326 PMCID: PMC2802058).

Schnabel RB, Sullivan LM, Levy D, Pencina MJ, Massaro JM, D'Agostino RB, Sr., Newton-Cheh C, Yamamoto JF, Magnani JW, Tadros TM, Kannel WB, Wang TJ, Ellinor PT, Wolf PA, Vasan RS, Benjamin EJ: Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study. Lancet 2009;373:739-745. (PubMed ID Number: 19249635 PMCID: PMC2764235).

Schwedhelm E, Xanthakis V, Maas R, Sullivan LM, Schulze F, Riederer U, Benndorf RA, Boger RH, Vasan RS: Asymmetric dimethylarginine reference intervals determined with liquid chromatography-tandem mass spectrometry: results from the Framingham offspring cohort. Clin Chem 2009;55:1539-1545. (PubMed ID Number: 19541865).

Shea MK, Benjamin EJ, Dupuis J, Massaro JM, Jacques PF, D'Agostino RB, Sr., Ordovas JM, O'Donnell CJ, Dawson-Hughes B, Vasan RS, Booth SL: Genetic and non-genetic correlates of vitamins K and D. Eur J Clin Nutr 2009;63:458-464. (PubMed ID Number: 18030310 PMCID: PMC2681093).

Stolerman ES, Manning AK, McAteer JB, Fox CS, Dupuis J, Meigs JB, Florez JC: TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study. Diabetologia 2009;52:614-620. (PubMed ID Number: 19183934).

Tucker KL, Jugdaohsingh R, Powell JJ, Qiao N, Hannan MT, Sripanyakorn S, Cupples LA, Kiel DP: Effects of beer, wine, and liquor intakes on bone mineral density in older men and women. Am J Clin Nutr 2009;89:1188-1196. (PubMed ID Number: 19244365 PMCID: PMC2667462).

Upadhyay A, Hwang SJ, Mitchell GF, Vasan RS, Vita JA, Stantchev PI, Meigs JB, Larson MG, Levy D, Benjamin EJ, Fox CS: Arterial stiffness in mild-to-moderate CKD. J Am Soc Nephrol 2009;20:2044-2053. (PubMed ID Number: 19608701 PMCID: PMC2736768).

Vasan RS: Commentary: C-reactive protein and risk prediction--moving beyond associations to assessing predictive utility and clinical usefulness. Int J Epidemiol 2009;38:231-234. (PubMed ID Number: 19129265 PMCID: PMC2639367).

Vasan RS, Glazer NL, Felix JF, Lieb W, Wild PS, Felix SB, Watzinger N, Larson MG, Smith NL, Dehghan A, Grosshennig A, Schillert A, Teumer A, Schmidt R, Kathiresan S, Lumley T, Aulchenko YS, Konig IR, Zeller T, Homuth G, Struchalin M, Aragam J, Bis JC, Rivadeneira F, Erdmann J, Schnabel RB, Dorr M, Zweiker R, Lind L, Rodeheffer RJ, Greiser KH, Levy D, Haritunians T, Deckers JW, Stritzke J, Lackner KJ, Volker U, Ingelsson E, Kullo I, Haerting J, O'Donnell CJ, Heckbert SR, Stricker BH, Ziegler A, Reffelmann T, Redfield MM, Werdan K, Mitchell GF, Rice K, Arnett DK, Hofman A, Gottdiener JS, Uitterlinden AG, Meitinger T, Blettner M, Friedrich N, Wang TJ, Psaty BM, Van Duijn CM, Wichmann HE, Munzel TF, Kroemer HK, Benjamin EJ, Rotter JI, Witteman JC, Schunkert H, Schmidt H, Volzke H, Blankenberg S: Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA 2009;302:168-178. (PubMed ID Number: 19584346 PMCID: PMC2975567).

Vasan RS, Pencina MJ, Robins SJ, Zachariah JP, Kaur G, D'Agostino RB, Ordovas JM: Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community. Circulation 2009;120:2414-2420. (PubMed ID Number: 19948972 PMCID: PMC2818786).

Vasan RS, Demissie S, Kimura M, Cupples LA, White C, Gardner JP, Cao X, Levy D, Benjamin EJ, Aviv A: Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study. Circulation 2009;120:1195-1202. (PubMed ID Number: 19752323 PMCID: PMC2857693).

Vasan RS: A risk score for risk factors: rationale and roadmap for preventing hypertension. Hypertension 2009;54:454-456. (PubMed ID Number: 19597035).

Velagaleti RS, Massaro J, Vasan RS, Robins SJ, Kannel WB, Levy D: Relations of lipid concentrations to heart failure incidence: the Framingham Heart Study. Circulation 2009;120:2345-2351. (PubMed ID Number: 19933936).

Wilk JB, Chen TH, Gottlieb DJ, Walter RE, Nagle MW, Brandler BJ, Myers RH, Borecki IB, Silverman EK, Weiss ST, O'Connor GT: A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet 2009;5:e1000429. (PubMed ID Number: 19300500 PMCID: PMC2652834).

Wise BL, Demissie S, Cupples LA, Felson DT, Yang M, Shearman AM, Aliabadi P, Hunter DJ: The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand. J Rheumatol 2009;36:2772-2779. (PubMed ID Number: 19884274).

Wolf PA: Stroke risk profiles. Stroke 2009;40:S73-S74. (PubMed ID Number: 19064807 PMCID: PMC2690862).

Zhang H, Wang M, Chen X: Willows: a memory efficient tree and forest construction package. BMC Bioinformatics. 2009 May;10:130. (PubMed ID Number: 19416535 PMCID: PMC2683818).

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