The Original Cohort of the Framingham Heart Study consisted of 5,209 respondents of a random sample of 2/3 of the adult population of Framingham, Massachusetts, 30 to 62 years of age by household, in 1948. Exam 28 for the Original Cohort ended in December of 2005. Exam 30 for the Original Cohort began in May of 2008 and ends in February of 2010.