The Framingham Heart Study
Lab (Blood or Urine)
Inflammatory Markers
INFLAMMATORY MARKERS
Phenotype Heritability Estimate PubMed & Heritability References Genome-wide association
studies
Age- and sex- adjusted Multivariable- adjusted
C-reactive protein 25.3% 28.2% PMID: 16159603 PMID: 17903293
Intercellular adhesion molecule-1 32.5% 25.7%±5.9% 30.4% 24.3%±6% PMID: 16159603
PMID: 15234428		 PMID: 17903293
Interleukin-6 25.4% 13.7% PMID: 16159603 PMID: 17903293
Urinary isoprostanes/urinary creatinine ~12% PMID: 12615693 PMID: 17903293
Monocyte chemoattractant protein-1 45.2% 44.0% PMID: 16159603 PMID: 17903293
P-selectin 45.4±5.8% 45.4±5.8% PMID: 17944986 PMID: 17903293
PMID: 17903293
Metabolic, Hormonal
DIABETES RELATED TRAITS
Phenotype Heritability Estimate PubMed & Heritability References Genome-wide association
studies
Age-, age2
- and sex-adjusted
Quantitative trait
ln(fasting plasma glucose) 34% PMID: 11872688 PMID: 11872688
ln(HbA1c) 47% PMID: 11872688 PMID: 11872688
ln(time-averaged fasting plasma glucose) 42% PMID: 11872688 PMID: 11872688
ln(fasting insulin) 41% PMID: 12739029 PMID: 12739029
ln(Homeostasis model insulin resistance, HOMA-IR) 42% PMID: 12739029 PMID: 12739029
ln(Insulin sensitivity index, ISI_0-120) 38% unpublished
ln(2-hr plasma glucose) 33% PMID: 11872688
ln(proinsulin) 32% unpublished
ln(adiponectin) 62% unpublished
ln(resistin) 30% unpublished
ln(Tumor necrosis factor alpha) 16% unpublished
VITAMINS
Phenotype Heritability Estimate PubMed & Heritability References Genome-wide association
studies
Age- and sex- adjusted Multivariable- adjusted
Plasma phylloquinone 13.4±11.1% (P=0.11) PMID: 18030310 PMID: 17903293
serum % undercarboxylated osteocalcin 15.9±11.8%, P=0.08 PMID: 18030310 PMID: 17903293
25-hydroxyvitamin D 28.8±11.3% PMID: 18030310 PMID: 17903293
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