Ankle-Arm Blood Pressure
| ANKLE-BRACHIAL INDEX |
| Phenotype |
Heritability
Estimate |
PubMed Reference |
| Ankle-brachial index, Offspring exam 6 |
0.21 |
PMID: 16928729 |
Bone Related
| BONE DENSITY AND ULTRASOUND |
| Phenotype |
Heritability Estimate |
PubMed Reference |
| femoral neck BMD |
0.52±0.05 |
PMID: 15003802 |
| lumbar spine BMD |
0.56±0.07 |
|
| Calcaneal BUA |
0.50±0.07 |
PMID: 17903296 |
| Calcaneal SOS |
0.37±0.06 |
|
| HIP GEOMETRY |
| Phenotype |
Heritability Estimate |
PubMed Reference |
| NSA, neck-shaft angle |
0.28±0.06** |
PMID: 17079199 |
| FNL, femoral neck length |
0.40±0.05 |
|
narrowest neck (NN)
subperiosteal width, WID |
0.49±0.06 |
PMID: 17903296 |
| NN CSA, cross-sectional area |
0.42±0.06 |
|
| NN Z, section modulus |
0.40±0.06 |
|
| Shaft WID |
0.63±0.05 |
|
| Shaft CSA |
0.44±0.06 |
|
| Shaft Z |
0.56±0.06 |
|
| METACARPAL GEOMETRY |
| Phenotype |
Heritability Estimate |
PubMed Reference |
| Metacarpal length |
0.82±0.04 |
PMID: 18449921 |
| Metacarpal width |
0.68±0.05 |
|
| Metacarpal cortical index (MCI) |
0.61±0.05 |
|
| Metacarpal cortical thickness (MCT) |
0.51±0.05 |
|
| Metacarpal Section Modulus (MZ) |
0.56±0.05 |
|
Pulmonary Function
| PULMONARY AND SLEEP WORKING GROUP |
| Phenotype |
Heritability Estimate |
PubMed Reference |
| FEV1 (mean across 2 exams) |
35% |
PMID: 11897646 |
| FVC (mean across 2 exams) |
49% |
PMID: 11897646 |
| FEV1/FVC ratio (mean across 2 exams) |
26% |
PMID: 11897646 |
| Change in FEV1 |
5% |
PMID: 11719305 |
| Change in FVC |
18% |
PMID: 11719305 |
| Change in FEV1/FVC ratio |
13% |
PMID: 11719305 |
| Smokers only change in FEV1 |
18% |
PMID: 11719305 |
| Smokers only change in FVC |
39% |
PMID: 11719305 |
| Smokers only change in FEV1/FVC |
14% |
PMID: 11719305 |
| % predicted FEV1 |
36% |
PMID: 17903307 |
| % predicted FVC |
45% |
PMID: 17903307 |
| % predicted FEV1/FVC |
29% |
PMID: 17903307 |
| % predicted FEF25-75 |
40% |
PMID: 17903307 |
| % predicted FEF/FVC |
41% |
PMID: 17903307 |
| Slope FEV1 |
10% |
PMID: 17903307 |
| Slope FEF25-75 |
20% |
PMID: 17903307 |
| Epworth Sleepiness Scale score |
29% |
PMID: 17903308 |
| Usual bedtime |
22% |
PMID: 17903308 |
| Usual sleep duration |
17% |
PMID: 17903308 |
Vascular
| VASCULAR FUNCTION |
| Phenotype |
Heritability Estimate |
PubMed Reference |
Genome-wide association
studies |
|
Age- and sex- adjusted |
Multivariable- adjusted |
|
|
| Brachial artery diameter, baseline |
|
25%9 to 33%10 |
PMID: 14769683
PMID: 17903301 |
PMID: 17903301 |
| Brachial artery flow velocity, baseline |
|
32%9 |
PMID: 17903301 |
PMID: 17903301 |
| Flow-mediated dilation, % |
|
14%10 to 19%9 |
PMID: 14769683
PMID: 17903301 |
PMID: 17903301 |
| Brachial artery hyperemic flow velocity |
|
6%9 |
PMID: 17903301 |
PMID: 17903301 |
|
