Appropriate applications and documents are provided for ancillary study proposals. The investigator should review the section on Ancillary Studies Overview and determine which application is appropriate for the proposal. All forms, including supplementary and supportive materials, should be completed according to the instructions. The proposal applications often require materials beyond completion of a proposal form. These additions can include, for example, for DNA applications, IRB approval, and distribution agreements signed by the investigator's institution. All required materials should be completed and submitted electronically to the FHS contact designated on the application form.