Research Application FAQSubmitting a Research Proposal
- How do I apply for an account at FHS?
- How do I submit a research proposal?
- Do I have to collaborate with a Framingham investigator?
- What is the deadline for my application?
- How do I request genetic data?
- How do I request clinical data?
- How do I request bio-specimens for genetic research?
- How do I request bio-specimens for non- genetic research?
- How do I request participant contact?
- What are some of the key review considerations of an application?
- Are there fees associated with receiving data or materials?
- Which committee(s) will review my application?
- How do I find out my application status?
- When do the committees review my proposal?
Submitting a Research Proposal
|For review by:||Application should be received by:|
|Executive Committee||Six weeks before grant deadlines and by the 3rd Monday of the month|
|Laboratory Committee||March 1, June 1, September 1, December 1|
|DNA Committee||January 15, April 15, July 15, October 15|
|Research Committee||Any time (rolling review)|
Requesting Data and Materials
How do I request genetic data?
Most of Framingham's genetic data is stored and accessible through dbGaP. Requests for Framingham genetic data not posted at dbGaP may be made by submitting a research proposal to Framingham's DNA Committee.
How do I request clinical data?
Much of Framingham's clinical data is stored and accessible through BioLINCC. Requests for Framingham clinical data not posted at BioLINCC may be made by submitting a research proposal to Framingham's Research Committee.
How do I request bio-specimens for genetic research?
Requests for Framingham DNA or other bio-specimens specifically for genetic research may be made by submitting a research proposal to Framingham's DNA Committee.
How do I request bio-specimens for non- genetic research?
Requests for Framingham bio-specimens specifically for non-genetic research may be made by submitting a research proposal to Framingham's Laboratory Committee.
- Does the proposal complement Framingham's research scope?
- Is collaboration with a Framingham investigator planned?
- Does the proposal require the unique characteristics of the FHS cohort(s)?
- Does the proposal put minimal demand on FHS resources?
- Does the proposal show proof of resources for conducting the project?
- Investigators are strongly encouraged to use Omni data/biospecimens. If they are proposing not using the Omni 1 when requesting Offspring data or Omni 2 when requesting Gen 3 data, the applicant must provide a compelling scientific rationale for the Omni's exclusion.
|Simple Data Request||$3,000|
|Moderate Data Request||$5,000|
|Advanced Data Request||$10,000|
- Simple = one exam visit, ≤ 100 variables.
- Moderate = multiple exam visits and/or outcome data, ≤ 100 variables.
- Advanced = multiple exam visits and/or outcome data, > 100 variables.
|Proposals Involving:||Will be reviewed by:|
|Application to a Sponsor for new funding||Executive Committee|
|New Participant Contact||Executive Committee|
|Third Party Involvement||Executive Committee|
|Genetic Research Requesting|
|New DNA Specimens with data||DNA Committee|
|Use of Extant DNA Specimens* with data
*DNA already in possession by the PI
|Genetic data (not available at dbGaP)||DNA Committee|
|Biological specimens with data (other than DNA)||DNA and Executive Committee|
|Research (not gene-based) Requesting|
|Previously collected clinical data||Research Committee|
|Pedigree structure||Research Committee|
|Biological specimens with data||Lab and Executive Committee|
|Exam chart review||Research Committee|
|Scan image data||Research Committee|
How do I find out my application status?
Applicants may check the status of submitted applications online using the application ID number and selecting "View Application History." Notification letters of review committee(s) decision(s) are also sent by e-mail.
When do the committees review my proposal?
Research Committee review is on a rolling review
Executive Committee meets monthly; (usually on the 4th Tuesday)
Laboratory Committee meets quarterly; about 3 weeks after the submission deadline
DNA Committee meets quarterly; about 3 weeks after the submission deadline
Types of Applications
What is an Addendum Application?
The Addendum Application allows investigators to extend the scientific aims of a previously approved application. An addendum application may request to add elements to a previously approved application or to follow up on the original application's resultant data through additional analyses, assays or subjects.
What is an Expedited DNA Application?
The Expedited DNA Application is available for rapid turn-around to follow-up on genetic results, such as genome-wide association study (GWAS) results and may be submitted at any time. Permission will only be granted if the preliminary data for follow-up has reached genome-wide significance.
Documents for Approved Applications
What is a Distribution Agreement?
The Framingham Data and Materials Distribution Agreement (DMDA) is a material transfer agreement. The investigator initiated agreement is required of all approved data and/or material distributions.
Do I need IRB Approval?
Investigator IRB approval is required of all approved data and/or material distributions along with the DMDA. Although Framingham data is de-identified, FHS is a study of a single community and hence one's identify can be more easily ascertained, even if traditional identifiers are removed.
What is a Third Party Agreement?
Proposals involving industry sponsorship, in kind services or collaboration with an investigator with industry ties will be evaluated in accordance with the procedures described at http://www.nhlbi.nih.gov/funding/policies/thirdparty.htm It will be the responsibility of the Principal Investigator to initiate the agreement through an appropriate contractual mechanism.
What is the Publication Policy?
All publications based on data from the Framingham Heart Study must have an acknowledgement of the Framingham Heart Study. All manuscripts and abstracts based on Framingham Heart Study data must be sent via e-mail to Ann Walsh, at email@example.com prior to submission for publication.