Research Application Overview, Review Process and Procedures


The Framingham Heart Study (FHS) is an epidemiologic study begun in Framingham in 1948 with 5,209 men and women. Since that time the FHS has studied three generations of participants resulting in biological specimens and data from nearly 15,000 participants. This clinically and genetically well-characterized population is a valuable scientific source that is maintained under the joint stewardship of Boston University and the NHLBI. Since 1994, two groups from minority populations, including related individuals have been added to the FHS.

The FHS Repository

Investigators seeking FHS data that is not available through dbGaP or BioLINCC (see below) or seeking biological specimens may submit a proposal through the FHS web-based research application. The FHS welcomes proposals from outside investigators. The catalogue of the FHS data repository may be accessed through this FHS website, under the "For Researchers" link, then "Description of Data", in order to determine if and how the desired data is stored.

Research interests beyond the core aspects of the FHS mission are initiated as ancillary studies. Proposals may involve the use of existing data, the collection of new data, either directly from participants or from previously collected samples, images, or other materials (e.g., medical records). The FHS Repository also has biological specimens available for genetic and non-genetic research proposals. Specimens include urine, blood and blood products, as well as DNA. After submission, proposals will be presented to the appropriate FHS review committee to determine feasibility and compliance with FHS policies.

Please see FHS Service Center for data and material distribution fees. In order to avoid fees, please consider applying for FHS data through an external data repository.

External Data Repositories

FHS clinical and research data is stored in the following repositories and may be accessed by application. These repositories are managed and administered independently of the Framingham Heart Study. There are no fees charged for data accessed through dbGaP or BioLINCC. Please check the following repositories before applying for data through FHS.


Framingham Heart Study molecular genetic data (e.g. SHARe (100K, 550K, and Omni5 SNPs), CARe (50K SNPs from ~2,100 candidate genes), Medical Resequencing (targeted re-sequencing), SABRe (proteomics, metabolomics/lipomics, immunoassays, gene expression and microRNA profiling), and ESP Heart-GO (exome sequencing)) in combination with the phenotypic data is now available through dbGaP at the Framingham Cohort link. New applications for all molecular genetic data linked to phenotypes should follow the process outlined at dbGaP.

NHLBI Repository

Much of Framingham's Original Cohort, Offspring, and Third Generation exam data is available through NHLBI's BioLINCC. New applications for clinical data should follow the process outlined at BioLINCC.