(based on Murabito, D'Agostino, Silbershatz, Wilson 'Intermittent Claudication: A risk profile from the Framingham Heart Study', Circulation 1997)
Outcome
Intermittent Claudication
Duration of follow-up
4-year intervals pooled for a total of 38 years
Population of interest
Individuals free of IC at the baseline examination
Predictors
- Age
- Sex
- Serum cholesterol
- Hypertension
- Cigarette smoking
- Diabetes
- Coronary heart disease
4-Year Probability of Intermittent Claudication
for Persons Aged 45-84 years
| Risk Factor |
Risk Factor Points |
Line Score |
| 0 |
+1 |
+2 |
+3 |
+4 |
+5 |
+6 |
+7 |
| Age, y |
45-49 |
50-54 |
55-59 |
60-64 |
65-69 |
70-74 |
75-79 |
80-84 |
|
| Sex |
Female |
|
|
Male |
|
|
|
|
| Cholesterol, mg/dL |
<170 |
170-209 |
210-249 |
250-289 |
>289 |
|
|
|
| Blood pressure |
Normal |
High Normal |
Stage 1 |
|
Stage 2+ |
|
|
|
| Cigarettes/d, n |
0 |
1-5 |
6-10 |
11-20 |
>20 |
|
|
|
| Diabetes |
No |
|
|
|
|
Yes |
|
|
| CHD |
No |
|
|
|
|
Yes |
|
|
| Point total |
| Points |
4-Year Probability |
| <10 |
<1% |
| 10-12 |
1% |
| 13-15 |
2% |
| 16-17 |
3% |
| 18 |
4% |
| 19 |
5% |
| 20 |
6% |
| 21 |
7% |
| 22 |
8% |
| 23 |
10% |
| 24 |
11% |
| 25 |
13% |
| 26 |
16% |
| 27 |
18% |
| 28 |
21% |
| 29 |
24% |
| 30 |
28% |
Stage 1 indicates stage 1 hypertension; stage 2+, greater than or equal to stage 2 hypertension; and CHD, coronary heart disease.
Logistic Regression coefficients for
direct estimation of 4-year IC risk
Coefficients Used in the Intermittent
Claudication Prediction Chart |
| Variable |
Beta |
| Intercept |
-8.9152 |
| Male sex |
0.5033 |
| Age |
0.0372 |
| Blood Pressure |
|
|
Normal |
0.0000 |
| High Normal |
0.2621 |
| Stage 1 Hypertension |
0.4067 |
| Stage 2+ Hypertension |
0.7977 |
| Diabetes |
0.9503 |
| Cigarettes/d |
0.0314 |
| Cholesterol, mg/dL |
0.0048 |
| CHD |
0.9939 |
