FHS Bibliography – 2026

Framingham Heart Study Bibliography – 2026

January

Akinlawon OJ, Parnell LD, Liu F, Arnett DK, Ordovas JM, Lai CQ. Epigenetic mediators of diet and lifestyle and insulin resistance. Genes Nutr. 2026;21(1):2. Epub 20260124. doi: 10.1186/s12263-025-00792-7. (PubMed PMID: 41580603; PMCID: PMC12914899).

Alhassan HA, Heckman E, Jha M, Vasan RS, Mitchell GF, Thomas RJ, Tsao CW. Association of Sleep Quality With Arterial Stiffness Measures in a Community-Based Sample. JACC Adv. 2026;5(2):102535. Epub 20260113. doi: 10.1016/j.jacadv.2025.102535. (PubMed PMID: 41534380; PMCID: PMC12830121).

Anderson DE, Keko M, James J, Allaire BT, Kozono D, Doyle PF, Kang H, Caplan S, Balboni T, Spektor A, Huynh MA, Bouxsein ML, Hackney DB, Alkalay RN. Metastatic Spine Disease Alters Vertebral Load-To-Strength Ratios in Cancer Patients Compared to Healthy Individuals. JOR Spine. 2026;9(1):e70111. Epub 20260106. doi: 10.1002/jsp2.70111. (PubMed PMID: 41502905; PMCID: PMC12772981).

Burton R, Durape S, Price E, Chien-Young K, Joshi P, Yhang E, Liu Y, Devine S, Gurnani AS, Ang TFA, Katz DI, Alosco ML, Tripodis Y, Au R, Dams-O’Connor K, Mez J. Traumatic Brain Injury and All-Cause and Dementia-Related Mortality in the Framingham Heart Study. JAMA Netw Open. 2026;9(1):e2555138. Epub 20260102. doi: 10.1001/jamanetworkopen.2025.55138. PubMed PMID: 41615690; PMCID: PMC12859724.

Francis L, Beiser A, Lu S, Kujawa SG, Heard-Costa N, Kolo FB, Kamboh MI, Bernal R, Welling DB, Alcabes RL, Himali JJ, Seshadri S. Hearing loss in the young-old is associated with increased risk for Alzheimer’s disease and vascular dementia. J Alzheimers Dis. 2026;109(3):1142-8. Epub 20260120. doi: 10.1177/13872877251407211. (PubMed PMID: 41555782; PMCID: PMC12855611).

Huang J, Rehman H, Doan C, Stein TD, Mez J, Ang TFA, Tao Q, Au R, Farrer LA, Zhang X, Qiu WQ. Circulating C-reactive protein influences polygenic risk of inflammatory genes expressed in brain endothelia for Alzheimer’s disease. Neurobiol Dis. 2026;219:107257. Epub 20260113. doi: 10.1016/j.nbd.2026.107257. (PubMed PMID: 41539445; PMCID: PMC12919661).

Kim W, Hu X, Kim K, Chun S, Orchard P, Qiao D, Ruczinski I, Saferali A, Aguet F, Antonacci-Fulton L, Balte PP, Bartz TM, Anamika WJ, Zhou X, Duan J, Brody JA, Cade BE, Daviglus ML, Doddapaneni H, Dugan-Perez S, Dutcher SK, Frazar CD, Gabriel SB, Gharib SA, Gupta N, Hobbs BD, Kasela S, Loehr LR, Metcalf GA, Muzny DM, Oelsner EC, Rasmussen-Torvik LJ, Sitlani CM, Smith J, Sofer T, Xu H, Yu B, Zhang D, Ziniti J, Barr RG, Carson AP, Fornage M, Hou L, Kalhan R, Kaplan R, Lappalainen T, London SJ, Morrison AC, O’Connor GT, Psaty BM, Raffield LM, Redline S, Rich SS, Rotter JI, Silverman EK, Manichaikul A, Cho MH.. Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants. Genome Biol. 2026;27(1):28. Epub 20260115. doi: 10.1186/s13059-025-03921-y. (PubMed PMID: 41535900; PMCID: PMC12888468).

Lázaro I, Luján-Barroso L, Soldevila-Domenech N, Amor AJ, Ortega E, Ros E, Sánchez MJ, Rodríguez-Barranco M, Guevara M, Moreno-Iribas C, Schröder H, Fitó M, Tintle NL, Ryder N, Harris WS, Agudo A, Sala-Vila A. Development of a blood-based lipidomic fat quality score for the risk of ischemic stroke. Eur Stroke J. 2026;11(1). doi: 10.1093/esj/23969873251367250. (PubMed PMID: 41614478).

Lee S, Miller CL, Bentley AR, Brown MR, Nagarajan P, Noordam R, Morrison JL, Schwander K, Westerman K, Kho M, Kraja AT, de Vries PS, Ammous F, Aschard H, Bartz TM, Do A, Dupont CT, Feitosa MF, Gudmundsdottir V, Guo X, Harris SE, Hikino K, Huang Z, Lefevre C, Lyytikäinen LP, Milaneschi Y, Nardone GG, Santin A, Schmidt H, Shen B, Sofer T, Sun Q, Tan YA, Tang J, Thériault S, van der Most PJ, Ware EB, Weiss S, Xing WY, Yu C, Zhao W, Ansari MAY, Anugu P, Attia JR, Bazzano LA, Bis JC, Breyer M, Cade B, Chen G, Collins S, Corley J, Davies G, Dörr M, Du J, Edwards TL, Faquih T, Faul JD, Fohner AE, Fretts AM, Gangireddy S, Gepner A, Graff M, Hofer E, Homuth G, Hood MM, Jie X, Kähönen M, Kardia SLR, Karvonen-Gutierrez CA, Launer LJ, Levy D, Maheshwari M, Martin LW, Matsuda K, McNeil JJ, Nolte IM, Okochi T, Raffield LM, Raitakari OT, Risch L, Risch M, Roux AD, Ruiz-Narvaez EA, Russ TC, Saito T, Schreiner PJ, Scott RJ, Shikany J, Smith JA, Snieder H, Spedicati B, Tai ES, Taylor AM, Taylor KD, Tesolin P, van Dam RM, Wang R, Wenbin W, Xie T, Yao J, Young KL, Zhang R, Zonderman AB; Biobank Japan Project; Lifelines Cohort Study,; Concas MP, Conen D, Cox SR, Evans MK, Fox ER, de Las Fuentes L, Giri A, Girotto G, Grabe HJ, Gu C, Gudnason V, Harlow SD, Holliday E, Jost JB, Lacaze P, Lee S, Lehtimäki T, Li C, Liu CT, Morrison AC, North KE, Penninx BWJH, Peyser PA, Province MM, Psaty BM, Redline S, Rosendaal FR, Rotimi CN, Rotter JI, Schmidt R, Sim X, Terao C, Weir DR, Zhu X, Franceschini N, O’Connell JR, Jaquish CE, Wang H, Manning A, Munroe PB, Rao DC, Chen H, Gauderman WJ, Bierut LJ, Winkler TW, Fornage M. Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations. HGG Adv. 2026;7(2):100566. Epub 20260110. doi: 10.1016/j.xhgg.2026.100566. (PubMed PMID: 41520179; PMCID: PMC12874302).

Li JM, Gauen AM, Zmora R, Stephen JJ, Petito LC, Scholtens D, Peterson EA, Kohli-Lynch C, Mansolf M, Sedaghat S, Giorgio K, Gross AL, Helmer C, Debette S, Soumaré A, Ikram MA, Wolters FJ, Seshadri S, Satizabal CL, Himali J, Levine DA, Briceño EM, Sorond FA, Launer LJ, Li D, Mbangdadji D, Zhao L, Lloyd-Jones DM, Lopez OL, Judd SE, Hughes TM, Gudnason V, Aiello AE, Fohner A, Singh-Manoux A, Allen NB. Midlife and late-life population attributable fractions of risk factors for dementia in the United States: The Dementia Risk Prediction Project. Alzheimers Dement. 2026;22(1):e71065. doi: 10.1002/alz.71065. (PubMed PMID: 41559019; PMCID: PMC12819166).

Naghavi M, Mirjalili SR, Atlas K, Reeves AP, Zhang C, Wasserthal J, Azimi A, Hashemi A, Mozafarybazargany M, Atlas T, Henschke CI, Yankelevitz DF, Zulueta JJ, Mechanick JI, Branch AD, Yip R, Roy SK, Nasir K, Fayad Z, McConnell MV, Kakadiaris IA, Rana JS, Vliegenthart R, Maron DJ, Narula J, Williams K Sr, Shah PK, Budoff MJ, Levy D, Mehran R, Kloner RA, Wong ND. AI-CVD-AF: A Novel Atrial Fibrillation Prediction Model Based on Coronary Artery Calcium Scans. Eur Heart J Cardiovasc Imaging. 2026. Epub 20260127. doi: 10.1093/ehjci/jeag027. (PubMed PMID: 41591983).

Mounsey LA, Chitsazan M, Shi I, Ribeiro PH, Parekh JK, Roshandelpoor A, Ndumele C, Allen NB, Khan SS, Psaty BM, Floyd JS, Levy D, de Boer RA, Suthahar N, Damman K, Odden MC, Gansevoort RT, Matsushita K, Hamo C, Dahabreh IJ, Yeh RW, Maddah M, Khurshid S, Ellinor PT, Lau ES, Kazi DS, Ho JE. Cardiovascular-Kidney-Metabolic Medication Eligibility Across National Survey, Community-Based, and Ambulatory Healthcare Samples. JAMA Cardiol. 2026. Epub 20260128. doi: 10.1001/jamacardio.2025.5305. (PubMed PMID: 41604173; PMCID: PMC12853287).

Nicholas JC, Alkis T, Bis JC, Boerwinkle E, Brody JA, Clish CB, de Vries PS, Gao Y, Gerzsten RE, Guo X, Johnson AD, Larson MG, Lemaitre RN, Psaty BM, Vasan RS, Reiner AP, Rich SS, Rodriguez B, Rong J, Rotter JI, Simino J, Smith NL, Wilson J, Yao J, Morrison AC, Yu B, Raffield LM. Fibrinogen-associated plasma metabolites and implications for coagulation, inflammation, and vascular diseases. J Thromb Haemost. 2026. Epub 20260108. doi: 10.1016/j.jtha.2025.12.016. (PubMed PMID: 41519271).

Sanni SA, Yu Y, Zhao Z. Ultra-high-dimensional threshold selection for quantile feature screening with false discovery rate error rate control: a case study on high blood pressure analysis. Biometrics. 2026;82(1). doi: 10.1093/biomtc/ujag035. (PubMed PMID: 41744039).

Shen J, Chen H, Gong Y, Huang Y, Wu M, Gu Y, Wang T, Fontana L, Rong S, Qian S, Tonetti M, Liu X, Yuan C. Association between plant-based diets and incident dementia: results from prospective cohort studies and a meta-analysis. J Prev Alzheimers Dis. 2026;13(2):100457. Epub 20260120. doi: 10.1016/j.tjpad.2025.100457. (PubMed PMID: 41564649; PMCID: PMC12856605).

Wadsworth ME, Page ML, Heberle BA, Miller JB, Steely CJ, Ebbert MTW. Dark and camouflaged genomic regions remain challenging in CHM13. Sci Rep. 2026;16(1):1557. Epub 20260112. doi: 10.1038/s41598-025-28283-0. (PubMed PMID: 41526367; PMCID: PMC12800076).

Wang D, Abbruzzese S, Heard-Costa N, Rampersaud A, Martin E, Naj A, Akgun B, Kunkle B, Seshadri S, Peloso G; Alzheimer’s Disease Neuroimaging Initiative; Alzheimer’s Disease Sequencing Project; DeStefano AL, Li Z, Li X, Choi SH. Application of the STAAR framework in detecting rare variant associations with Alzheimer disease and related dementias: Insights and implications. HGG Adv. 2026;7(2):100574. Epub 20260120. doi: 10.1016/j.xhgg.2026.100574. (PubMed PMID: 41560352; PMCID: PMC12934298).

Zahoor S, Liò P, Dias G, Hasanuzzaman M. Integrating probabilistic trees and causal networks for clinical and epidemiological data. Artif Intell Med. 2026;173:103350. Epub 20260106. doi: 10.1016/j.artmed.2026.103350. (PubMed PMID: 41512598).

Zhang Y, Joehanes R, Huan T, Weber LM, Yang Q, Lunetta KL, Levy D, Liu C. Integration of latent factor analysis into multivariable Mendelian randomization. Eur J Epidemiol. 2026. Epub 20260112. doi: 10.1007/s10654-025-01324-8. (PubMed PMID: 41524881).

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February

Alyousifi Y, Raut C, Chen VL, Oliveri A, Chen Y, Speliotes EK. Genetic Information Enhances a Novel Non-Invasive Steatosis Index and Outperforms Existing Steatosis Indices. Liver Int. 2026;46(2):e70410. doi: 10.1111/liv.70410. (PubMed PMID: 41521699).

Bugbird AR, Whittier DE, Burt LA, Boyd SK. Longitudinal associations between changes in bone mechanical strength and fracture risk estimated by μFRAC. J Bone Miner Res. 2026;41(2):112-9. doi: 10.1093/jbmr/zjaf111. (PubMed PMID: 40823712; PMCID: PMC12865857).

Cao L, Sundquist K, Zhang Y, Memon AA, Hedelius A, Li N, Ji J, Sundquist J, Zheng D, Wang X. Combining Mendelian randomization and experimental approaches for the identification of miRNAs related to major depressive disorder. J Affect Disord. 2026;403:121394. Epub 20260212. doi: 10.1016/j.jad.2026.121394. (PubMed PMID: 41690636).

Chen J, Doyle MF, Cao Y, Iyer S, Ragab AAY, Murabito JM, Lunetta KL. Circulating immune cell phenotypes are associated with inflammatory biomarkers in dementia-free participants from the Framingham Heart Study Offspring cohort. Sci Rep. 2026;16(1). Epub 20260227. doi: 10.1038/s41598-026-41423-4. (PubMed PMID: 41760714; PMCID: PMC13049175).

Chi S, Li X, Wei P, Huang X. MELODY: Mediation Analysis in Logistic Regression for High-Dimensional Mediators and a Binary Outcome. Genet Epidemiol. 2026;50(1):e70033. doi: 10.1002/gepi.70033. (PubMed PMID: 41560457; PMCID: PMC12820538).

Davis DN, Gajjar P, Xanthakis V, Lloyd-Jones D, Nayor M. Refined Heart Failure Stages Incorporating Cardiorespiratory Fitness Are Differentially Associated With Heart Failure Risk in the Community. J Am Heart Assoc. 2026;15(4):e045791. Epub 20260212. doi: 10.1161/jaha.125.045791. (PubMed PMID: 41676947; PMCID: PMC13055785).

Ding H, Orwig TA, Rong J, Tatere HY, Liu C, Schramm E, Pathiravasan CH, Murabito JM, Lin H. Associations Between Smartphone-Based Finger Tapping and Cognitive Performance in Older Adults: Observational Study. J Med Internet Res. 2026;28:e82463. Epub 20260218. doi: 10.2196/82463. (PubMed PMID: 41707186; PMCID: PMC12916091).

Ganglberger W, Sun H, Turley N, Tripathi A, Hadar P, Gupta A, Gallagher K, Tesh R, Kim S, Nasiri S, Leng Y, Harrison S, Stone KL, Hughes T, Redline S, Au R, Manoach DS, Landolt HP, Huber R, Mignot E, Shin C, Cash SS, Thomas RJ, Westover MB. Brain Health from Sleep EEG: A Multicohort, Deep Learning Biomarker for Cognition, Disease, and Mortality. NEJM AI. 2026;3. Epub 20260226. doi: 10.1056/aioa2500487. (PubMed PMID: 41953210; PMCID: PMC13055923).

Gifford KA, Rong J, Schramm E, Zhang Y, Pathiravasan CH, Benjamin EJ, Lin H, Liu C, Au R, Libon DJ, Murabito JM. Digital Stroop Test as a neurocognitive marker in a community-based sample of older adults: Data from the Framingham Heart Study. J Alzheimers Dis. 2026;110(1):463-70. Epub 20260210. doi: 10.1177/13872877251415030. (PubMed PMID: 41668525).

Liu Z, Kim S, Cho H. Comprehensive Analysis of Asynchronous Binary Variable Associations in Longitudinal End-of-Life Studies. Stat Med. 2026;45(3-5):e70438. doi: 10.1002/sim.70438. (PubMed PMID: 41711102).

Mirjalili SR, Atlas K, Reeves AP, Zhang C, Wasserthal J, Azimi A, Hashemi A, Mozafarybazargany M, Ghaffari Jolfayi A, Atlas T, Henschke CI, Yankelevitz DF, Zulueta JJ, Fan W, Mechanick JI, Branch AD, Fayad Z, McConnell MV, Rana JS, Vliegenthart R, Maron DJ, Narula J, Budoff MJ, Mehran R, Williams KA Sr, Shah PK, Mechanic O, Agatston AS, Kloner RA, Wong ND, Naghavi M. AI-CVD-HF: A heart failure risk prediction model based on coronary artery calcium scans compared with PREVENT-HF. Am J Prev Cardiol. 2026;27:101464. Epub 20260210. doi: 10.1016/j.ajpc.2026.101464. (PubMed PMID: 42291061; PMCID: PMC13261169).

Ofosuhene B, Ding H, Tatere HY, Vigeant TW, Li S, Bennett A, Lin H. Association between electrocardiographic age and cognitive function: findings from the UK biobank and Framingham Heart Study. Eur Heart J Digit Health. 2026;7(3):ztag034. Epub 20260218. doi: 10.1093/ehjdh/ztag034. (PubMed PMID: 41799659; PMCID: PMC12966501).

Tao Q, Ang TFA, Huang J, Itchapurapu IS, Mez J, Alosco M, Au R, Farrer LA, Zhang X, Qiu WQ. Blood PCSK9 Impacts Alzheimer’s Disease Risk in an APOE Genotype-Dependent Manner: A Prospective Cohort Study. Health Sci Rep. 2026;9(2):e71810. Epub 20260222. doi: 10.1002/hsr2.71810. (PubMed PMID: 41737429; PMCID: PMC12927996).

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March

Bernatz S, Prudente V, Pai S, Attermann AK, Cao Y, Chen J, Lyass A, Foldyna B, Nürnberg L, Bressem K, Abbosh C, Swanton C, Jamal-Hanjani M, Lu MT, Murabito JM, Lunetta KL, Birkbak NJ, Aerts HJWL. Thymic health consequences in adults. Nature. 2026;652(8111):986-94. Epub 20260318. doi: 10.1038/s41586-026-10242-y. (PubMed PMID: 41851466; PMCID: PMC13102717).

Frank B, Gurnani A, Hurley L, Guan C, Andersen SL, Devine SA, O’Connor MK, Budson A, Liu C, Lin H, Auerbach S, Liu Y, Libon DJ, Price CC, Farrer L, Mez J, Ang A, Au R. Psychometric modeling of Boston process approach data for dementia prediction in the Framingham Heart Study. J Int Neuropsychol Soc. 2026;32(3):243-54. Epub 20260414. doi: 10.1017/s1355617726101921. (PubMed PMID: 41975557; PMCID: PMC13082455).

Gao V, Jacques PF, Ma J. Diet quality attenuates the association between flavonoid intake and hepatic steatosis risk in the Framingham Heart Study. Br J Nutr. 2026:1-9. Epub 20260331. doi: 10.1017/s0007114526106825. (PubMed PMID: 41913372).

Giorgio K, Stephen JJ, Mansolf M, Peterson EA, Gross AL, Briceño EM, Levine DA, Helmer C, Debette S, Soumaré A, Ikram MA, Wolters FJ, Seshadri S, Satizabal CL, Himali JJ, Launer LJ, Li D, Mbangdadji D, Lloyd-Jones DM, Sorond FA, Zhao L, Lopez OL, Judd SE, Hughes TM, Guðnason V, Aiello AE, Fohner A, Singh-Manoux A, Sabayan B, Pankow JS, de Vries PS, Yaffe K, Beiser A, Dehghan A, Zmora R, Scholtens D, Lutsey PL, Allen NB, MacLehose R, Sedaghat S. Risk factors for early-onset and late-onset dementia: a prospective cohort study. Lancet Healthy Longev. 2026;7(3):100831. Epub 20260402. doi: 10.1016/j.lanhl.2026.100831. (PubMed PMID: 41936382).

Korzinski TJ, Prescott BR, Hamel-Sellman DJ, Xanthakis V, Cooper LL, Hamburg NM, Tsao CW, Benjamin EJ, Vasan RS, Mitchell GF. Development and Validation of the AI-HeartAge Model in Framingham and UK Biobank. Hypertension. 2026;83(6):e26209. Epub 20260319. doi: 10.1161/hypertensionaha.125.26209. (PubMed PMID: 41853838; PMCID: PMC13004166).

Leng Y, Ding H, Li Y, Liu X, Wang M, Cao Y, Lyu C, Levy D, Ma J, Liu C. Sex-Specific Fifteen-Year Alcohol Consumption Trajectories and Their Association with Cardiovascular Events and Mortality: The Framingham Heart Study. Nutrients. 2026;18(5). Epub 20260305. doi: 10.3390/nu18050849. (PubMed PMID: 41830019; PMCID: PMC12986612).

Levine DA, Hayward RA, Sussman JB, Whitney RT, Gałecki AT, Briceño EM, Gross AL, Giordani BJ, Elkind MSV, Gaskin DJ, Gottesman RF, Sidney S, Yaffe K, Burke JF. Alternative clinical trial designs to find a clinically important effect size of blood pressure-lowering on cognitive impairment and dementia. J Alzheimers Dis. 2026;111(1):211-21. Epub 20260330. doi: 10.1177/13872877261430953. (PubMed PMID: 41910458; PMCID: PMC13120728).

Maher S, Scott MR, Buckley RF, DeCarli CS, Aparicio HJ, Romero JR, Vasan RS, Murabito JM, Bhasin S, Beiser AS, Seshadri S, McGrath ER. Number of Live Births as a Protective Factor Against Clinical and Covert Brain Infarcts: The Framingham Heart Study. J Am Heart Assoc. 2026;15(7):e044037. Epub 20260318. doi: 10.1161/jaha.125.044037. (PubMed PMID: 41848034; PMCID: PMC13279095).

Oh J, Shin YE. A Surrogate-Calibrated Updating Method for Logistic Regression With Missing Covariates. Stat Med. 2026;45(6-7):e70489. doi: 10.1002/sim.70489. (PubMed PMID: 41830128; PMCID: PMC12988319).

Palatsides EL, Himali D, Cribb L, Peloso GM, Ryan J, Yang Q, Decarli CS, Beiser AS, Seshadri S, Cavuoto MG, Yiallourou S, Baril AA, Himali JJ, Pase MP. Association of an Aquaporin-4 Haplotype With Cognition, Brain Volume, and Dementia Risk in Community-Dwelling Individuals Without Dementia. Neurology. 2026;106(7):e214773. Epub 20260319. doi: 10.1212/wnl.0000000000214773. (PubMed PMID: 41855452).

Pan S, Vasan RS, Beiser AS, Seshadri S, Xanthakis V. Associations of Left Atrial Dimension and Ventricular Mass With Long-Term Health Outcomes: Framingham Heart Study. JACC Adv. 2026;5(4):102643. Epub 20260311. doi: 10.1016/j.jacadv.2026.102643. (PubMed PMID: 41819678; PMCID: PMC12997219).

Pradhan R, Petrovic Z, Sadman Sakib M, Schröder S, Manfred Krüger D, Pena T, Diniz E, Burkhardt S, Schütz AL, Gisa V, Grzadzielewska I, Toischer K, Stein TD, Blusztajn JK, Delalle I, Radulovic J, Sananbenesi F, Fischer A. Neuid: A Novel Neuron-Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer’s Disease. Adv Sci (Weinh). 2026;13(29):e14972. Epub 20260314. doi: 10.1002/advs.202514972. (PubMed PMID: 41831315; PMCID: PMC13205658).

Sun H, Milton S, Fang Y, Taha HB, Shiju S, Thomas RJ, Ganglberger W, Pase MP, Hughes T, Purcell S, Redline S, Stone KL, Yaffe K, Westover MB, Leng Y. Machine Learning-Based Sleep Electroencephalographic Brain Age Index and Dementia Risk: An Individual Participant Data Meta-Analysis. JAMA Netw Open. 2026;9(3):e261521. Epub 20260302. doi: 10.1001/jamanetworkopen.2026.1521. (PubMed PMID: 41854616; PMCID: PMC13003368).

Trimarchi MP, Namjou-Khales B, Ben-Baruch Morgenstern N, Rochman M, Chen X, Osswald GA, Besse JA, Shook MS, Caldwell JM, Lape M, Shoda T, Weirauch MT, Ruffner MA, Constantine GM, Martin LJ, Kottyan LC, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Investigators. Multitrait analysis of genome-wide association studies expands eosinophilic esophagitis genetic susceptibility and polygenic risk scores. J Allergy Clin Immunol. 2026. Epub 20260320. doi: 10.1016/j.jaci.2026.03.008. (PubMed PMID: 41865802; PMCID: PMC13173691).

Wu X. Deep-Neural-Network-Aided Genetic Association Testing in Samples with Related Individuals. Curr Issues Mol Biol. 2026;48(3). Epub 20260304. doi: 10.3390/cimb48030273. (PubMed PMID: 41899425; PMCID: PMC13025615).

Yang X, Kim MS, Zhu X, Uddin MM, Nakao T, Cho SMJ, Koyama S, Xu T, Reeskamp LF, Zhang R, Liu Z, A Y, de Vries PS, Vasan RS, Boerwinkle E, Morrison AC, Psaty BM, Tracy RP, Heckbert SR, Cho MH, Yun JH, Palmer ND, Bowden DW, Murabito JM, Levy D, Heard-Costa NL, O’Connor GT, Becker LC, Kral BG, Yanek LR, Raffield LM, Hidalgo B, Rotter JI, Rich SS, Taylor KD, Post WS, Kooperberg C, Reiner AP, Mitchell BD, Kardia SLR, Smith JA, Peyser PA, Bielak LF, Yon DK, Won HH, Arnett DK, Smith AV, Gabriel SB, Ellinor PT; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Natarajan P, Wang M, Fahed AC. An integrated germline and somatic genomic model for coronary artery disease. Nat Commun. 2026;17(1). Epub 20260326. doi: 10.1038/s41467-026-70379-2. (PubMed PMID: 41888514; PMCID: PMC13187175).

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April

Aggarwal M, Joehanes R, Huan T, Courchesne P, Dupuis J, O’Connor G, Levy D. Integrative Proteomic Profiling of Blood Pressure and Hypertension. Hypertension. 2026;83(6):e26407. Epub 20260409. doi: 10.1161/hypertensionaha.125.26407. (PubMed PMID: 41953991; PMCID: PMC13078717).

Alexandrou M, Parikh NI, Brilakis ES, Lloyd-Jones DM, Xanthakis V. Insights Into Cardiovascular Disease in Women From the Framingham Heart Study. JACC Adv. 2026;5(6 Pt 1):102722. Epub 20260417. doi: 10.1016/j.jacadv.2026.102722. (PubMed PMID: 41999366; PMCID: PMC13309318).

Azimi A, Atlas K, Reeves AP, Zhang C, Wasserthal J, Mirjalili SR, Mozafarybazargany M, Hashemi A, Atlas T, Henschke CI, Yankelevitz DF, Zulueta JJ, Branch AD, Roy SK, Nasir K, Molloi S, Rana JS, Fayad ZA, McConnell MV, Abela GS, Vliegenthart R, Maron DJ, Narula J, Williams KA Sr, Shah PK, Budoff MJ, Benjamin EJ, Mehran R, Kloner RA, Wong ND, Naghavi M. AI-Derived LA Volume Index, LA/RA and LA/LV Volume Ratios From Coronary Artery Calcium Scans Predict Long-Term Atrial Fibrillation and Stroke. Stroke. 2026;57(6):1586-601. Epub 20260408. doi: 10.1161/strokeaha.125.053401. (PubMed PMID: 41948813; PMCID: PMC13078722).

Campos A, Liu T, Prescott B, Ma J, Haff MG, Walker ME, Mohanty A, Xanthakis V. Association of Life’s Essential 8 with Hepatic Fibrosis, MASLD, and MetALD in the Framingham Heart Study. Nutrients. 2026;18(8). Epub 20260417. doi: 10.3390/nu18081276. (PubMed PMID: 42075086; PMCID: PMC13118321).

Chaudhary M, Alam MA, Zafar S, Shakil KA, Wani MA, Alshuhri S, Abubeker KM. AI-driven integration of Framingham Heart Study data with machine learning, deep learning, and explainable AI for enhanced pharmaceutical marketing. Sci Rep. 2026;16(1). Epub 20260409. doi: 10.1038/s41598-026-45770-0. (PubMed PMID: 41957161; PMCID: PMC13233955).

Dookhy J, Cummings M, Price E, Liu Y, Gutierrez-Gomez S, O’Shea S, Frank S, Au R, Gurnani AS, Ang TFA, Mez J, Shih LC. Dementia Incidence in Individuals With Parkinson’s Disease in the Framingham Heart Study. Ann Clin Transl Neurol. 2026;13(7):1493-7. Epub 20260407. doi: 10.1002/acn3.70383. (PubMed PMID: 41944089; PMCID: PMC13358564).

Ek Orloff L, De Lisio M. Relationship between myeloid skewing and colorectal cancer risk in the Framingham Heart Study. Front Oncol. 2026;16:1773537. Epub 20260422. doi: 10.3389/fonc.2026.1773537. (PubMed PMID: 42100425; PMCID: PMC13143660).

Goldstein D, Sahelijo N, Priyadarshi D, Panitch R, Nho K, Farrer LA, Stein TD, Jun GR. Blood-Brain Network-Based Polygenic Risk Scores Reveal Biomarker Signatures and the Progression of Alzheimer’s Disease. J Clin Med. 2026;15(8). Epub 20260410. doi: 10.3390/jcm15082885. (PubMed PMID: 42074686; PMCID: PMC13116307).

Huang YJ, Kurniansyah N, Goodman MO, Spitzer BW, Wang J, Stilp A, Laurie C, de Vries PS, Chen H, Min YI, Sims M, Peloso GM, Guo X, Bis JC, Brody JA, Raffield LM, Smith JA, Zhao W, Rotter JI, Rich SS, Redline S, Fornage M, Kaplan R, Franceschini N, Levy D, Morrison AC, Boerwinkle E, Smith NL, Kooperberg C, Psaty BM, Zöllner S; Trans-Omics for Precision Medicine Consortium; Sofer T. Admixture-informed polygenic risk reporting using the ePRS framework. Nat Commun. 2026;17(1). Epub 20260430. doi: 10.1038/s41467-026-72457-x. (PubMed PMID: 42062286; PMCID: PMC13323344).

Kim T, Song J, Joo JWJ. Risk prediction for cardiovascular related diseases using PRS and EHR in the Framingham Heart Study. PloS One. 2026;21(4):e0345914. Epub 20260417. doi: 10.1371/journal.pone.0345914. (PubMed PMID: 41996407; PMCID: PMC13089760).

Liu M, Khasiyev F, Spagnolo-Allende A, Sanchez DL, Andrews H, Yang Q, Beiser A, Qiao Y, Romero JR, Rundek T, Brickman AM, Manly JJ, Elkind MS, Seshadri S, Chen C, Del Brutto OH, Hilal S, Wasserman BA, Tosto G, Fornage M, Gutierrez J. Multi-population genome-wide association study identifies multiple novel loci associated with asymptomatic intracranial large artery stenosis. Int J Stroke. 2026;21(4):515-25. Epub 20250824. doi: 10.1177/17474930251374471. (PubMed PMID: 40851121).

Marino FR, Ganglberger W, Sun H, Liu Y, Ding H, Thomas RJ, Au R, Westover B. Better Sleep Now, Better Cognition Later? Predicting Cognitive Function Using A Machine Learning-Based Sleep EEG Brain Health Score. Sleep. 2026. Epub 20260408. doi: 10.1093/sleep/zsag100. (PubMed PMID: 41964500).

Mirjalili SR, Atlas K, Reeves AP, Zhang C, Wasserthal J, Azimi A, Hashemi A, Mozafarybazargany M, Ghaffari Jolfayi A, Atlas T, Henschke CI, Yankelevitz DF, Zulueta JJ, Mechanick J, Branch AD, Ma N, Yip R, Fan W, Roy SK, Nasir K, Molloi S, Fayad Z, McConnell MV, Kakadiaris IA, Abela G, Vliegenthart R, Maron DJ, Narula J, Williams KA Sr, Shah PK, Budoff MJ, Levy D, Mehran R, Kloner RA, Wong ND, Naghavi M. Comparing incidence of heart failure in individuals with enlarged cardiac chambers versus diabetes. Am J Prev Cardiol. 2026;29:101656. Epub 20260429. doi: 10.1016/j.ajpc.2026.101656. (PubMed PMID: 42403463; PMCID: PMC13329587).

Mulligan M, Beiser AS, Ghosh S, Banerjee A, Aparicio H, Romero JR, Tracy RP, Seshadri S, McGrath ER. Association Between Nerve Growth Factor and Clinical Stroke and Covert Brain Infarcts: The FHS. J Am Heart Assoc. 2026;15(9):e045426. Epub 20260420. doi: 10.1161/jaha.125.045426. (PubMed PMID: 42003591; PMCID: PMC13279100).

Peloso GM, Wang D, Abbruzzese SM, Bis JC, Choi SH, Beiser A, Bressler J, Dupuis J, Fohner AE, Ghanbari M, Gibbs RA, Heard-Costa N, Ikram MA, Lacaze P, Le Grand Q, Lopez OL, Mosley TH, Riaz M, Soumaré A, Yaqub A, Boerwinkle E, Psaty BM, Fornage M; TOPMed Neurocognitive Working Group, The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Sequencing Project; Seshadri S, DeStefano AL. Whole genome sequencing analysis of over 3500 individuals dementia-free over 85 years old. J Alzheimers Dis. 2026;111(4):1772-82. Epub 20260423. doi: 10.1177/13872877261444302. (PubMed PMID: 42024100; PMCID: PMC13162269).

Qian F, Gajjar P, Prescott B, Mitchell GF, Xanthakis V, Rade JJ, Nayor M. Modifiable Correlates With Systemic Thromboxane Generation and Association With Cardiovascular Outcomes: Results From the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2026;46(6):e324561. Epub 20260423. doi: 10.1161/atvbaha.126.324561. (PubMed PMID: 42021731; PMCID: PMC13120735).

Tang R, An J, Bellows BK, Moran AE, Allen NB, Wilkins JT, Xanthakis V, Tsai MY, Shah NS, Reynolds K, Zhang Y. Traditional and Emerging Lipid Markers for Cardiovascular Risk Assessment in Young vs Older Adults. JAMA Netw Open. 2026;9(4):e265199. Epub 20260401. doi: 10.1001/jamanetworkopen.2026.5199. (PubMed PMID: 41945347; PMCID: PMC13058767).

Xanthakis V, Prescott B, Ning H, Krishnan V, Lloyd-Jones DM. Relating Cumulative Life’s Essential 8 Score With Cardiovascular Disease and Death: The Framingham Heart Study. JACC Adv. 2026;5(5):102706. Epub 20260416. doi: 10.1016/j.jacadv.2026.102706. (PubMed PMID: 41996786; PMCID: PMC13101685).

Xiong H, Cao X, Han X, Zhang JX, Zhuang JR, He S, Zhu M, Li J, Qin W. Evaluation of coronary heart disease risk prediction based on simple physical examination parameters by machine learning model: a retrospective cohort model development and validation study. Front Cardiovasc Med. 2026;13:1821221. Epub 20260430. doi: 10.3389/fcvm.2026.1821221. (PubMed PMID: 42147060; PMCID: PMC13171337).

Yang J, Ogunsola S, Wong J, Wang A, Joehanes R, Levy D, Sharma S, Liu C, Xie J. A mammalian genomic signature shaped by single nucleotide variants regulates transcriptome integrity and diversity. Genome Biol. 2026;27(1). Epub 20260429. doi: 10.1186/s13059-026-04094-y. (PubMed PMID: 42057098; PMCID: PMC13270564).

Zhang W, Lukacsovich D, Young JI, Gomez L, Schmidt MA, Kunkle BW, Chen X, Martin ER, Wang L. The aging epigenome: integrative analyses reveal intersection with Alzheimer’s disease. Geroscience. 2026;48(3):3185-203. Epub 20260414. doi: 10.1007/s11357-026-02195-x. (PubMed PMID: 41975027; PMCID: PMC13356189).

Zhang Y, Nguyen NQH, Hanson PA, Sevilla-Gonzalez M, Haessler J, Sarnowski C, Yao J, Yu B, Jamshidi A, Boerwinkle E, Brown MR, Chen ZZ, Ida Chen YD, Clish C, DiCorpo D, Durda P, Gerszten R, Goodarzi MO, Guo X, Heard-Costa NL, Johnson WC, Kooperberg C, Pankow JS, Post WS, Reiner AP, Rich SS, Rotter JI, de Vries PS, Wood AC, Taylor KD, Manning AK, Dupuis J, Meigs JB, Liu CT. Plasma metabolomic profiles associated with cardiovascular disease in type 2 diabetes from the Trans-Omics for Precision Medicine (TOPMed) program. Atherosclerosis. 2026;417:120758. Epub 20260426. doi: 10.1016/j.atherosclerosis.2026.120758. (PubMed PMID: 42085744; PMCID: PMC13241174).

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May

Bugbird AR, Burghardt AJ, Langsetmo L, Ensrud KE, Bouxsein ML, Kiel DP, Boyd SK, Whittier DE. External validation of a novel HR-pQCT based fracture risk assessment tool (μFRAC) in a male cohort: the osteoporotic fractures in men (MrOS) study. J Bone Miner Res. 2026;41(6):629-37. doi: 10.1093/jbmr/zjaf187. (PubMed PMID: 41474190; PMCID: PMC13229941).

Chen H, Hailili G, Tong LS, Fei L, Cao Y, Xu X, Li X, Melo van Lent D, Yuan C. Adherence to the MIND diet and longitudinal brain structural changes over a decade: evidence from the Framingham heart study offspring cohort. J Neurol Neurosurg Psychiatry. 2026;97(6):505-12. Epub 20260514. doi: 10.1136/jnnp-2025-336957. (PubMed PMID: 41844283).

Fisher N, Xue L, Smith KK, Tao B, Cunha JA, Ladenheim S, Moreira-Bouchard JD, Milstone ZJ, Zhebrun A, Zhang X, Jun GR, Stein TD, Ang TFA, Farrer LA, Farb MG, Padera RF, Benjamin EJ, Levy D, Gopal DM, Isaac RS, Lenburg ME, Choi SH, Fetterman JL. Mitochondrial genetic variation across tissues of the human body. Nucleic Acids Res. 2026;54(10). doi: 10.1093/nar/gkag513. (PubMed PMID: 42179041; PMCID: PMC13199689).

Goldberg RL, Zhao Y, Murabito J, Cheng S, Vasan RS, Levy D, Mitchell GF, Benjamin EJ, Lau ES. Association of cardiometabolic disease with subclinical cardiac remodeling in men vs women in the Framingham Heart Study. Eur J Prev Cardiol. 2026. Epub 20260518. doi: 10.1093/eurjpc/zwag269. (PubMed PMID: 42150810; PMCID: PMC13429261).

Koprulu M, Smith-Byrne K, Ferolito BR, Macdonald-Dunlop E, Luan J, Hedman ÅK, Ogamba CF, Kuliesius J, Repetto L, Ramisch A, Abbasi F, Ärnlöv J, Assimes TL; BeLOVE Study Group; Björck HM, Björkander S, Böttcher M, Butterworth AS, Chen Z, Cho K, Clarke RJ, Cox SR, Czene K, Danesh J, Dedoussis G, Elmståhl S, Eriksson N, Eriksson P, Esko T; Estonian Biobank Research Team; Ferreiro-Iglesias A, Franks PW, Fu J, Gaziano JM, Ghanbari M, Gieger C, Gilly A, Grallert H, Gunter MJ, Gustafsson S, Göteson A, Hall PFL, Hansson O, Harris SE, Hayward C, Herder C, Hernandez-Pacheco N, Hijazi Z, Hillary RF, Hopewell JC, Hu S, Hwang SJ, Jern C, Johansson Å, Jonsson L, Kalnapenkis A, Kerrison ND, Kho PF, Klaric L, Kohleick L, Kraft J, Landén M, Levy D, Li L, Lind L, Long J, Mattsson-Carlgren N, Melén E, Merid SK, Mertins P, Michaëlsson K, Møller PL, Murgia F, Nyegaard M, Park YC, Pearson E, Peters J, Petrie JR, Png G, Polašek O, Prins BP, Ripke S, Roden M, Rohde PD, Said S; SCALLOP Consortium; Shen X, Schwenk JM, Siegbahn A, Smith JG, Stanne TM, Suhre K, Sundström J, Thorand B, Valdes-Marquez E, Vallerga CL, van Meurs JBJ, Viñuela A, Võsa U, Wallentin L, Walters RG, Wareham NJ, Weber JE, Weersma RK, Wilson JF, Winther S, Yasmeen S, Zanetti D, Zeggini E, Zhao JH, Zhernakova A, Zhernakova DV, Ziehm M, Kessler BM, Pereira AC, Mälarstig A, Pietzner M, Langenberg C. Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome. Cell. 2026;189(11):3339-57.e11. Epub 20260506. doi: 10.1016/j.cell.2026.03.049. (PubMed PMID: 42097137; PMCID: PMC13343581).

Liu D, Talevi V, Tavares JF, Wang R, Imtiaz MA, Melas K, Teumer A, Wittfeld K, Hillary RF, Vojinovic D, Beekman M, Armstrong NJ, Estrada S, Völzke H, Bülow R, Royle NA, Wardlaw JM, Wen W, Sachdev PS, Mather KA, Slagboom PE, Cox SR, Grabe HJ, Yang Q, Aziz NA, Breteler MMB. DNA methylation signatures of bilateral hippocampal volume, asymmetry and atrophy: a cross-omics analysis in the general population. EBioMedicine. 2026;128:106289. Epub 20260511. doi: 10.1016/j.ebiom.2026.106289. (PubMed PMID: 42114417; PMCID: PMC13191633).

Muller E, Guan C, Gifford KA, Sunderaraman P, Devine S, Liu Y, Hwang PH, Gurnani AS. The Montreal Cognitive Assessment at the Framingham Heart Study: A Re-Examination of the Norms. Brain Behav. 2026;16(5):e71487. doi: 10.1002/brb3.71487. (PubMed PMID: 42112960; PMCID: PMC13159545).

Naskinova I, Kolev M, Milev M, Kalinov H, Lazarova M, Stoilova S, Nikolova I. Bidirectional Associations Between Blood Glucose and Blood Pressure: A Data-Driven Causal Analysis Using Structural Equation Modelling and Granger Causality on NHANES Longitudinal Data. J Clin Med. 2026;15(10). Epub 20260513. doi: 10.3390/jcm15103751. (PubMed PMID: 42194713; PMCID: PMC13207677).

Sangeetha V, Basha SM, Ahmed ST, Khan SB, Shabaz M, Algarni A, Basheer S. Development of AI based behavioral feature patterns on influencing asymptomatic cardiovascular disease attributes: a dataset standardization approach. Sci Rep. 2026;16(1). Epub 20260521. doi: 10.1038/s41598-026-52859-z. (PubMed PMID: 42168274; PMCID: PMC13408492).

Spartano NL, Prescott B, Walker ME, Shi E, Venkatesan G, Fei D, Lin H, Murabito JM, Ahn D, Battelino T, Edelman SV, Fleming GA, Freckmann G, Galindo RJ, Joubert M, Lansang MC, Mader JK, Mankovsky B, Mathioudakis NN, Mohan V, Peters AL, Shah VN, Spanakis EK, Waki K, Wright EE, Zilbermint M, Wolpert HA, Steenkamp DW. Expert Clinical Interpretation of Continuous Glucose Monitor Reports From Individuals Without Diabetes. J Diabetes Sci Technol. 2026;20(3):727-35. Epub 20250212. doi: 10.1177/19322968251315171. (PubMed PMID: 39936548; PMCID: PMC11822776).

Tao Q, Han J, Ang TFA, Hou L, Liu C, Murabito JM, Lunetta KL, Mez J, Alosco ML, Stein TD, Zhang X, Au R, Farrer L, Palmisano JN, Hamburg NM, Qiu WQ. Peripheral vascular function, including endothelium-dependent measures, and dementia risk: The Framingham Heart Study. Alzheimers Dement. 2026;22(5):e71396. doi: 10.1002/alz.71396. (PubMed PMID: 42050369; PMCID: PMC13124649).

Xu G, Zhuang X, Amei A, Wang Z, Oh EC. Age-varying DNA methylation patterns associated with blood pressure in mid-to-late adulthood. Clin Epigenetics. 2026;18(1). Epub 20260506. doi: 10.1186/s13148-026-02092-2. (PubMed PMID: 42092955; PMCID: PMC13147566).

Yao Z, Dardari ZA, LaMonte MJ, Matsushita K, Ballantyne CM, Lima JA, Vasan RS, Simonsick EM, Appel LJ, Cohen DL, Judd S, Cawthon PM, Shah AM, Weber BN, Cao T, Dzaye O, Tasdighi E, Jelwan Y, Jha KK, Psaty BM, Bis JC, Olson NC, Lash JP, Cushman M, Eaton CB, Blaha MJ. The Prognostic Value of Serum Interleukin-6 Concentrations for 9 Cardiovascular and Mortality Outcomes: The Cross Cohort Collaboration (CCC). J Am Coll Cardiol. 2026;88(3):282-98. Epub 20260527. doi: 10.1016/j.jacc.2026.04.015. (PubMed PMID: 42201287).

Young VM, Wiedner C, Baril AA, Pase MP, Ruiz A, Salardini A, Frei CR, Kautz T, Bernal R, Yiallourou S, Cribb L, Beiser A, Teixeira AL, Himali JJ, Seshadri S. Non-linear associations between sleep duration and plasma p-tau181 in the Framingham Heart Study. Alzheimers Dement. 2026;22(5):e71499. doi: 10.1002/alz.71499. (PubMed PMID: 42156936).

Zhang J, Moll M, Debban CL, Hobbs BD, Rijhwani H, Washko GR, Celli BR, Silverman EK, Bakke P, Oelsner EC, Barr RG, Agustí A, Faner R, Bruselle GG, Humphries SM, Lynch DA, Dupuis J, Manichaikul AW, O’Connor GT, Cho MH. Body Mass Index-related genetic factors and COPD imaging phenotypes. Annals of the American Thoracic Society. 2026;23(5):720-7. doi: 10.1093/annalsats/aaoag007. (PubMed PMID: 41721747; PMCID: PMC13152661).

Zhang Y, Wang M, Joehanes R, Huan T, Weber LM, Yang Q, Lunetta KL, Levy D, Liu C. Multivariate mendelian randomization for joint inferences of correlated outcomes. Eur J Epidemiol. 2026. Epub 20260528. doi: 10.1007/s10654-026-01406-1. (PubMed PMID: 42207415).

Zhao M, Yan M, Fei L, Chen H, Wu M, Li Y, Huang L, Shen J, Liu G, Guasch-Ferré M, Salas-Salvadó J, Yuan C. Nut Consumption and Long-Term Risk of All-Cause Dementia: Preliminary Findings from Three Prospective Cohort Studies. Nutrients. 2026;18(11). Epub 20260528. doi: 10.3390/nu18111722. (PubMed PMID: 42280365; PMCID: PMC13258416).

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June

Ambatipudi M, McNeill JN, Roshandelpoor A, Alotaibi M, Mounsey LA, Hoffman E, O’Connor G, Choi SH, Allen NB, Barr RG, Jain M, Cheng S, Ho JE. The association of eicosanoids with lung structure and function: Findings from the Multi-Ethnic Study of Atherosclerosis lung study and Framingham Heart Study. PloS One. 2026;21(6):e0351692. Epub 20260630. doi: 10.1371/journal.pone.0351692. (PubMed PMID: 42378232; PMCID: PMC13318034).

Ho K, Hwang PH. Mid-to-late-life social network size and resilience to neurodegeneration: The Framingham Heart Study. BMC Neurol. 2026. Epub 20260617. doi: 10.1186/s12883-026-05080-4. (PubMed PMID: 42310578).

Huang L, Hailili G, Zhao M, Chen H, Shen J, Yan M, Shen T, Wu M, Fei L, Liu X, Xu W, Agarwal P, Yuan C. Association of vegetable and fruit intake with risk of dementia: 3 prospective studies and meta-analysis of cohort studies. Am J Clin Nutr. 2026;124(3):101421. Epub 20260627. doi: 10.1016/j.ajcnut.2026.101421. (PubMed PMID: 42364910).

Mulligan MD, Scott MR, Yang Q, Wang R, Ghosh S, Johnson KA, Beiser AS, Seshadri S, McGrath ER. Association of Circulating Vitamin D in Midlife With Increased Tau-PET Burden in Dementia-Free Adults. Neurol Open Access. 2026;2(2). Epub 20260401. doi: 10.1212/wn9.0000000000000057. (PubMed PMID: 41938573; PMCID: PMC13045725).

Palatsides EL, Yiallourou S, Himali D, Cavuoto MG, Baril AA, Yang Q, Peloso GM, Ryan J, El Fakhri G, Ghosh S, Thibault E, DeCarli CS, Johnson KA, Beiser AS, Seshadri S, Himali JJ, Pase MP. Influence of an AQP4 haplotype and sleep duration on early Alzheimer’s disease. Alzheimers Dement. 2026;22(6):e71540. doi: 10.1002/alz.71540. (PubMed PMID: 42222915; PMCID: PMC13239115).

Pope MK, Chugh H, Truyen T, Mathias M, Uy-Evanado A, Lin H, Atar D, Bosson N, Reinier K, Benjamin EJ, et al. Dynamic Risk Trajectories for Sudden Cardiac Arrest: The Role of Recurrent Cardiovascular Events. J Am Heart Assoc. 2026;15(13):e049853. Epub 20260623. doi: 10.1161/jaha.125.049853. (PubMed PMID: 42333668).

Raman S, Thakkar D, Calixte J, Kumar R, Sporn K, Marla K, Goel D, Gopali R, Chetla N, Pasha S, Ravisankar N, Lee R, Ionita C. Machine Learning for Coronary Heart Disease Prediction: Comparative Analysis of Framingham and Cleveland Subset of the UCI Dataset with SHAP-Based Interpretability. Epidemiologia (Basel). 2026;7(3). Epub 20260601. doi: 10.3390/epidemiologia7030075. (PubMed PMID: 42346163; PMCID: PMC13298444).

Tang A, Collazo Martinez AD, Kim M, Shahidzadeh A, Ting SJ, Vaidya B, Jiang X, Le HV, Wang R, Beiser A, Sobrin L, Seshadri S, Kashani AH. Effect of Optical Coherence Tomography Angiography Image Artifacts on Quantitation of Vessel Density and Perfusion. Ophthalmic Surg Lasers Imaging Retina. 2026;57(6):383-92. Epub 20260601. doi: 10.3928/23258160-20260501-02. (PubMed PMID: 42274715; PMCID: PMC13289213).

Teichman J, Chen MH, Thibord F, Chan MV, Nkambule BB, Lachapelle AR, Ma J, Joehanes R, Liu C, Aponte AM, Panicker SR, Kanthi Y, Levy D, Johnson AD. DNA Methylation Variation in Blood Cells may Impact Platelet Function. TH Open. 2026;10:a28839068. Epub 20260619. doi: 10.1055/a-2883-9068. (PubMed PMID: 42343978; PMCID: PMC13289646).

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July

Adhikari S, Ogedegbe OG, Devinsky O. The Roseto Study: Selection Bias Versus Social Support. Cureus. 2026;18(7):e113024. Epub 20260720. doi: 10.7759/cureus.113024. (PubMed PMID: 42518891; PMCID: PMC13384420).

Cooper LL, Prescott BR, Xanthakis V, Rong J, Larson MG, Benjamin EJ, Hamburg NM, Vasan RS, Mitchell GF. Interrelations of aortic spring function, cardiovascular disease risk factors, and left ventricular diastolic function: The Framingham Heart Study. Physiol Rep. 2026;14(13):e70985. doi: 10.14814/phy2.70985. (PubMed PMID: 42374884; PMCID: PMC13315821).

Hirsch JA, Besser LM, Pescador Jimenez M, Dickinson ST, Cornelius T, Francisco ST, Lawin K, Abdel Magid HS, Albrecht SS, Bai Allen N, Balte P, Barber S, Bateman LA, Beach LB, Block JP, Brown SC, Buhr RG, Chambers EC, Crooks JL, Diez Roux AV, Elkind MSV, Gallo LC, Gordon-Larsen P, Gutierrez J, Isasi CR, James P, Judd SE, Kanaya AM, Kandula NR, Kaufman JD, Kershaw KN, Kucharska-Newton AM, Kulick ER, Lee JS, Lovasi GS, Mauger D, McClure LA, Melly S, Merkin SS, Michael YL, Oates GR, Phillips BR, Reese JA, Regan EA, Reimer CJ, Rodriguez DA, Rundek T, Schembri M, Sims M, Spartano NL, Wilson C, Zhang Y, Oelsner EC. Spatial and neighborhood data in the collaborative cohort of cohorts for COVID-19 Research (C4R). PloS one. 2026;21(7):e0352170. Epub 20260722. doi: 10.1371/journal.pone.0352170. (PubMed PMID: 42485397; PMCID: PMC13390819).

Lakomski N, Giorgio K, Stephen J, Mansolf M, Soumaré A, Gross AL, Aiello AE, Singh-Manoux A, Ikram MA, Helmer C, Satizabal CL, Levine DA, Lloyd-Jones DM, Briceño EM, Sorond FA, Wolters FJ, Himali JJ, Launer LJ, Mbangdadji D, Li D, Zhao L, Lopez OL, Debette S, Seshadri S, Judd SE, Hughes TM, Guðnason V, Griswold M, de Vries PS, Fohner A, Lutsey PL, Zmora R, Peterson EA, Scholtens D, Allen NB, Sedaghat S. The Association Between APOE Genotype, Race, and Dementia: An Analysis of 7 Population-Based Cohort Studies. Neurol Genet. 2026;12(4):e200417. Epub 20260716. doi: 10.1212/nxg.0000000000200417. (PubMed PMID: 42519715; PMCID: PMC13382979).

Lioutas VA, Fletcher E, Hyacinth HI, DeCarli C, Aparicio HJ, Romero JR, Seshadri S, Beiser A. Stroke-Related Acceleration of Brain Atrophy beyond Aging in the Framingham Study: Paired Pre- and Post-MRI Evidence and Cognitive Associations. Cerebrovasc Dis. 2026:1-10. Epub 20260724. doi: 10.1159/000553203. (PubMed PMID: 42497104).

Lozano-Esparza S, Shakt GE, Brody JA, Martinez-Perez A, Conomos MP, Germain M, Clapham KR, Teder-Laving M, van Hylckama Vlieg A, Kauko A, Thibord F, Bezerra OCL, Nadkarni GN, Munsch G, Nøst TH, Goode EL, Ji Y, Chasman DI, Reiner AP, Turman C, Wiggins KL, Sitlani CM, Souto JC, Lutsey PL, Bellomo T, Biobank E, Program MV, Li-Gao R, Winstén AK, Chen MH, Do R, Gourhant L, Hveem K, Armasu SM, Saut N, Pankratz N, Giulianini F, Haessler J, Song M, Olaso R, Boerwinkle E, Dochtermann D, Soria JM, Rich SS, Smadja D, Koyama S, Rosendaal FR, Niiranen T, Gagnon F, Vy HMT, Zakai N, Lemarie C, Skogholt AH, Deleuze JF, Pankow JS, Ridker PM, Liu Y, Rice KM, Pyarajan S, Cushman M, Emmerich J, Psaty BM, Natarajan P, Johnson AD, Rodger MA, Suchon P, Couturaud F, Morange PE, Tang W, Kooperberg C, Kabrhel C, Sabater-Lleal M, Trégouët DA, Wolberg AS, Damrauer SM, Smith NL. Genetic associations with pulmonary embolism among those with a deep vein thrombosis: the International Network Against Venous Thrombosis Consortium. J Thromb Haemost. 2026. Epub 20260727. doi: 10.1016/j.jtha.2026.06.046. (PubMed PMID: 42508647; PMCID: PMC13529309).

Orchard P, Blackwell TW, Kachuri L, Castaldi PJ, Cho MH, Christenson SA, Durda P, Gabriel S, Hersh CP, Huntsman S, Hwang S, Joehanes R, Johnson M, Li X, Lin H, Liu CT, Liu Y, Mak ACY, Manichaikul AW, Paik DT, Saferali A, Smith JD, Taylor KD, Tracy RP, Wang J, Wang M, Weinstock JS, Weiss J, Wheeler HE, Zhou Y, Zöllner S, Wu JC, Mestroni L, Graw S, Taylor MRG, Ortega VE, Johnson WC, Gan W, Abecasis G, Nickerson DA, Gupta N, Ardlie K, Woodruff PG, Bowler RP, Meyers DA, Reiner A, Kooperberg C, Ziv E, Vasan RS, Larson MG, Cupples LA, Silverman EK, Rich SS, Heard-Costa N, Tang H, Rotter JI, Smith AV, Levy D, Aguet F, Scott LJ, Raffield LM, Parker SCJ, Abe N, Almasy L, Ament S, Anugu P, Auer P, Avramopoulos D, Balasubramanian A, Barr RG, Barwick L, Beaty T, Becker D, Becker L, Beitelshees A, Benos T, Bezerra M, Bis J, Brody J, Broeckel U, Broome J, Bunting K, Buth E, Carey V, Carty C, Casaburi R, Chaffin M, Chang C, Chang YC, Chavan S, Chen BJ, Chen WM, Choi SH, Chuang LM, Chung RH, Conomos M, Cornell E, Crandall C, Crapo J, Curtis J, Damcott C, David S, de Las Fuentes L, de Vries P, Deka R, DeMeo D, Devine S, Dinh H, Doddapaneni H, Duan Q, Duggirala R, Eaton C, Ekunwe L, El Boueiz A, Emery L, Farber C, Farek J, Franceschini N, Frazar C, Fu M, Fullerton SM, Fulton L, Gao S, Gao Y, Gass M, Geiger H, Ghosh A, Gignoux C, Glahn D, Gogarten S, Gong DW, Goring H, Grine D, Gu CC, Guan Y, Hall M, Han Y, Harris D, Heavner B, Herrington D, Hobbs B, Hong E, Hoth K, Hsiung CA, Hu J, Hung YJ, Huston H, Hwu CM, Jackson R, Jain D, Johnsen J, Johnston R, Jones K, Kessler M, Khan A, Khan Z, Kim W, Kimoff J, Kinney G, Kramer H, Lange C, Lange E, Laurie C, Laurie C, LeBoff M, Lee S, Lee WJ, Levine D, Lewis J, Li Y, Lin X, Liu S, Liu Y, Make B, Manning A, Manson J, Martin L, Marton M, Mathai S, May S, McArdle P, McDonald ML, McFarland S, McGoldrick D, McHugh C, Mei H, Meigs J, Menon V, Min N, Moll M, Momin Z, Montasser M, Mychaleckyj JC, Naik R, Naseri T, Natarajan P, Nelson SC, Neltner B, Nessner C, Nkechinyere O, O’Connell J, O’Connor T, Ochs-Balcom H, Okwuonu G, Pankow J, Parker C, Peloso G, Peralta JM, Perez M, Perry J, Peters U, Phillips LS, Pollin T, Becker JP, Boorgula MP, Psaty B, Qiao D, Rafaels N, Rajendran M, Rasmussen-Torvik L, Ratan A, Reed R, Regan E, Reupena MS, Robillard R, Roselli C, Ruczinski I, Runnels A, Russell P, Ryan K, Sabino EC, Salimi S, Salvi S, Salzberg S, Sandow K, Santibanez J, Schwander K, Sciurba F, Sériès F, Shetty A, Shetty A, Silver B, Skomro R, Smith T, Smoller S, Snively B, Stilp AM, Storm G, Streeten E, Su JL, Sung YJ, Sylvia J, Szpiro A, Taub M, Taylor S, Thornton TA, Threlkeld M, Tinker L, Tirschwell D, Tiwari H, Tong C, Tsai M, Vaidya D, Walker T, Wallace R, Walts A, Wang FF, Wang H, Watson K, Watt J, Weng LC, Wessel J, Williams K, Wilson C, Wilson J, Winterkorn L, Wong Q, Wu B, Xu H, Yanek L, Yang I, Zekavat SM, Zhao SX, Zhao W, Zhu X. Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed. Science. 2026;393(6808):eadx2989. Epub 20260716. doi: 10.1126/science.adx2989. (PubMed PMID: 42462027).

Saw WY, Kim K, Huang Y, Yun JH, Ma X, Bacon J, Pershad Y, Levy D, O’Connor GT, Boerwinkle E, Barr RG, Rich SS, Rotter JI, Carson AP, Raffield LM, Gharib SA, Bartz TM, Psaty BM, Sofer T, North KE, Kaplan RC, Oelsner EC, Manichaikul A, Bick AG, Scheet P, Reiner AP, Jakubek YA, Auer PL, Cho MH, DeMeo DL. Mosaic loss of Y chromosome associates with lung function, emphysema, and epigenetic aging. Am J Respir Crit Care Med. 2026;212(7):1483-94. doi: 10.1093/ajrccm/aamag120. (PubMed PMID: 42085243; PMCID: PMC13322295).

Yiallourou S, Wiedner C, Yang Q, Baril AA, Misialek JR, Kline CE, Harrison S, Bernal R, Bisson A, Himali D, Chiu T, Cavuoto MG, Ancoli-Israel S, Xiao Q, Vaou EO, Weihs A, Leng Y, Gottesman RF, Beiser AS, Lopez OL, Lutsey PL, Purcell S, Redline S, Seshadri S, Stone KL, Yaffe K, Pase MP, Himali JJ. Association of Sleep Variables With Cognitive Performance and the Risk of Dementia in the Sleep and Dementia Consortium. Neurology. 2026;107(4):e218182. Epub 20260729. doi: 10.1212/wnl.0000000000218182. (PubMed PMID: 42525904).

Zhang Y, Schaefer EJ, Ikezaki H, Diffenderfer MR, Lloyd-Jones DM, Hoogeveen RC, Ballantyne CM, DeFilippis AP, Guan W, Tsai MY, Liu CT. Comprehensive Evaluation of Atherosclerotic Cardiovascular Disease Risk Predictors Across the Pooled Cohort Equations, Predicting Risk of Cardiovascular Disease Events, and an Expanded Model. J Am Heart Assoc. 2026;15(15):e049726. Epub 20260731. doi: 10.1161/jaha.125.049726. (PubMed PMID: 42535551).

Zhao Y, Jacques PF, Lajous M, Sebastiani P, Ordovás JM. Sustained fish intake and 21-year Alzheimer’s disease risk: a target trial emulation. Am J Epidemiol. 2026. Epub 20260727. doi: 10.1093/aje/kwag140. (PubMed PMID: 42506897).

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August

Daneshvar DH, Nowinski CJ, Abdolmohammadi B, Luster CB, Uretsky M, Martin BM, Palmisano JN, Weuve J, McClean MD, Cherry JD, Dwyer B, Feigel ED, Mastrodicasa MJ, Alvarez VE, Rabinovici GD, Seeley WW, Grinberg LT, Crary JF, Stein TD, Goldstein L, Katz DI, Zafonte RD, Tripodis Y, Cantu RC, Stern RA, Alosco ML, McKee AC, Mez J. Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21. BMJ. 2026;394:e100418. Epub 20260825. doi: 10.1136/bmj-2026-100418. (PubMed PMID: 42642105).

Dardari ZA, Yao Z, Zhang J, Bakoyannis G, Nan H, Staten LK, Jha KK, Tasdighi E, Jelwan Y, Burka S, Matsushita K, Lima JAC, Psaty BM, Fretts AM, Lemaitre RN, Cohen DL, Appel LJ, Khera A, Shah AM, Hall ME, Judd SE, Safford MM, Cole SA, Vasan RS, Benjamin EJ, Cawthon PM, Orwoll E, LaMonte MJ, Eaton CB, El Khoudary SR, Jackson EA, Janssen I, Lotufo PA, Bensenor IM, Bittencourt MS, Bhatt AS, Ricardo AC, Blaha MJ. Risk Reclassification Beyond BMI by Waist Circumference and Waist-to-Hip Ratio Across 9 Cardiovascular Outcomes: Results From the Cross-Cohort Collaboration. J Am Coll Cardiol. 2026;88(6):670-84. doi: 10.1016/j.jacc.2026.05.050. (PubMed PMID: 42583989; PMCID: PMC13470613).

He J, Zhang Y, Wang X, Spartano NL, Rong J, Benjamin EJ, Ang TFA, Au R, Lin H, Schramm E, Borrelli B, Liu C, Murabito JM. Associations Between Smartwatch-Derived Measures and Cognitive Function: Findings From the Electronic Framingham Heart Study. J Am Heart Assoc. 2026;15(16):e049284. Epub 20260807. doi: 10.1161/jaha.126.049284. (PubMed PMID: 42568104).

Kornej J, Benjamin EJ, Ellinor PT, Lin H, Trinquart L, Haimovich JS, Khurshid S, Lubitz SA, Preis SR. Epidemiology of pacemaker implantation in the community: findings from the Framingham Heart Study. Int J Cardiol Heart Vasc. 2026;66:101984. Epub 20260826. doi: 10.1016/j.ijcha.2026.101984. (PubMed PMID: 42699625; PMCID: PMC13543974).

Krishnan V, Ravichandran S, Gajjar P, Perry AS, Miller PE, Vasan RS, Shah RV, Lewis GD, Kiel DP, Nayor M. Body Composition, Obesity, and Cardiorespiratory Fitness in the Community. Med Sci Sports Exerc. 2026. Epub 20260818. doi: 10.1249/mss.0000000000004105. (PubMed PMID: 42611635).

Kurniansyah N, Tasaki S, Rehman H, Zhu C, Farrell J, Sherva R, Hauger R, Merritt VC, Panizzon M, Zhang R, Gaziano JM, Gim J, Lee K, Lee DY, Nho K, Vialle RA, Mukherjee S, Trittschuh EH, Lee AJ, Brickman AM, Cruchaga C, Risacher S, Greve DN, Crane P, Martin E, Bush WS, Mayeux R, Haines JL, Pericak-Vance MA, Logue M, Bennett DA, Barnes LL, Saykin A, Hohman T, Wang LS, Schellenberg GD, Ang TFA, Au R, Mez J, Lunetta KL, Zhang X, Farrer LA. A multiancestry polygenic risk score for Alzheimer’s disease is associated with cognitive decline and neuropathological hallmarks in diverse populations. Nat Genet. 2026;58(9):2141-51. Epub 20260827. doi: 10.1038/s41588-026-02722-8. (PubMed PMID: 42661068; PMCID: PMC13553296).

Li R, Okoro PC, Zillikens MC, Vasan RS, Sahni S, Rivadeneira F, Kiel DP, Medina-Gomez C. The association of gut microbiome composition with musculoskeletal features in middle-aged and older adults: A two-cohort joint study. Bone. 2026;213:118051. Epub 20260813. doi: 10.1016/j.bone.2026.118051. (PubMed PMID: 42595281).

Marino FR, Ding H, Lin H, Au R, Hwang PH. How Life-Course Trajectories of Physical Activity Track With Cognitive Decline. J Phys Act Health. 2026:1-9. Epub 20260805. doi: 10.1123/jpah.2026-0133. (PubMed PMID: 42562373).

Marino FR, Ganglberger W, Sun H, Liu Y, Ding H, Thomas RJ, Au R, Westover MB. Sleep electroencephalography-derived brain health and long-term cognitive decline in community-dwelling adults. Sleep Adv. 2026;7(3):zpag089. Epub 20260806. doi: 10.1093/sleepadvances/zpag089. (PubMed PMID: 42769852; PMCID: PMC13592772).

Mulligan MD, Wang R, Yang Q, Beiser AS, Maillard P, Satizabal C, Ghosh S, Tanner J, Johnson KA, DeCarli C, Tracy RP, Levy D, Benjamin EJ, El Fakhri G, Vasan RS, Seshadri S, McGrath ER. Mid-life candidate vascular plasma biomarkers are associated with MRI markers of vascular brain injury and amyloid- and tau-PET in cognitively healthy adults. J Alzheimers Dis. 2026:13872877261480733. Epub 20260830. doi: 10.1177/13872877261480733. (PubMed PMID: 42669799).

Muthukumar YG, Vijayakumar KA, Cho GW. Ensemble DNA methylation clock demonstrates Immune-metabolic aging signatures associated with mortality. Mech Ageing Dev. 2026;233:112240. Epub 20260822. doi: 10.1016/j.mad.2026.112240. (PubMed PMID: 42632601).

Noumegni SR, Juraschek SP, Cohen JB, Echouffo-Tcheugui JB. Glycemia, Insulin Sensitivity Markers and Arterial Stiffness: The Framingham Heart Study. Hypertension. 2026;83(10):e26375. Epub 20260826. doi: 10.1161/hypertensionaha.125.26375. (PubMed PMID: 42644239).

Okorie M, Jonson C, Oddi AP, Castruita PA, Fulton-Howard B, Yaffe K, Yokoyama JS, Udeh-Momoh C, Andrews SJ. Cross-ancestry polygenic risk scores enhance Alzheimer’s disease risk prediction in multiethnic cohorts. Alzheimers Dement. 2026;22(8):e71529. doi: 10.1002/alz.71529. (PubMed PMID: 42522059; PMCID: PMC13415749).

Olayinka O, Farrell JJ, Zhu C, Khurshid Z, Martin ER, Bush WS, Pericak-Vance MA, Wang LS, Schellenberg GD, Haines JL, Lunetta KL, Zhang X, Farrer LA. Stratification by a polygenic risk score of common variation aids in Alzheimer’s disease rare variant discovery. Alzheimers Dement. 2026;22(8):e71710. doi: 10.1002/alz.71710. (PubMed PMID: 42557982; PMCID: PMC13444717).

Tang R, An J, Moran AE, Shimbo D, Allen NB, Xanthakis V, Reynolds K, Zhang Y. Isolated Diastolic Hypertension and Cardiovascular Disease Risk in Young Adults. Hypertension. 2026;83(10):e27333. Epub 20260817. doi: 10.1161/hypertensionaha.126.27333. (PubMed PMID: 42605677; PMCID: PMC13483358).

Walker ME, Prescott B, Stockero S, Xanthakis V, Lin H, Gerszten RE, McKeown NM, Jacques PF, Vasan RS. Proteomic signature of healthy dietary patterns and risk of cardiovascular disease in the framingham heart study. Clin Nutr. 2026;65:106758. Epub 20260813. doi: 10.1016/j.clnu.2026.106758. (PubMed PMID: 42617399).

Wang N, DiCorpo DA, Zhang Y, Kleinbrink E, Arnett DK, Barnard J, Blangero J, Bowden DW, Carson AP, Chen YI, Chung MK, Curran JE, Darbar D, Duggirala R, Ellinor PT, Fatkin D, Fornage M, Heard-Costa N, He J, Hou L, Kardia SLR, Kooperberg C, Loos RJF, McManus DD, Mitchell BD, Minster RL, North KE, Psaty BM, Raffield LM, Redline S, Rich SS, Roden D, Rotter JI, Shoemaker MB, Smith JD, Van Wagoner DR, Aguet F, Ardlie K, Bis JC, Brody JA, Cade BE, Clish CB, de Vries PS, Floyd JS, Freedman BI, Gabriel S, Gerzsten RE, Goodarzi MO, Gu C, Guo X, Gupta N, Heckbert SR, Hsu S, Hung YJ, Kalyani RR, Kelly TN, Kinney GL, Li C, Liu S, Liu Y, Lloyd-Jones DM, Manson JE, Mathias RA, Mercader JM, Morrison AC, Naseri T, Onengut S, Palmer ND, Peyser PA, Qi Q, Raghavan S, Reiner AP, Rooney MR, Sevilla-Gonzalez M, Sarnowski C, Smith JD, Smith JA, Spartano NL, Tahir U, Taylor KD, Tobias DK, Tracy RP, Viali S, Wang H, Wood AC, Yanek LR, Zhao W, Zheng Y, Dupuis J, Liu CT, Sladek R, Wessel J, Meigs JB, Manning AK. Colocalization of eQTLs With Type 2 Diabetes and Glycemic Traits Using Whole-Genome Sequences in Diverse Populations From the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program. Diabetes. 2026;75(8):1477-91. doi: 10.2337/db25-0557. (PubMed PMID: 42274313; PMCID: PMC13381659).

Yiannakou I, Jacques PF, Long MT, Beiser A, Pickering RT, Moore LL. Development and validation of a modified Dietary Approaches to Stop Hypertension (mDASH) index in the community-based Framingham Heart Study Second Generation cohort. Clin Nutr. 2026;66:106766. Epub 20260819. doi: 10.1016/j.clnu.2026.106766. (PubMed PMID: 42753339).

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September