FHS Bibliography – 2020
Framingham Heart Study Bibliography – 2020
January
Agami S, Zucker DM, Spiegelman D. Estimation in the Cox survival regression model with covariate measurement error and a changepoint. Biom J. 2020. Epub 2020/02/01. doi: 10.1002/bimj.201800085. (PubMed ID Number: 32003495).
Agarwal R, Song RJ, Vasan RS, Xanthakis V. Left Ventricular Mass and Incident Chronic Kidney Disease. Hypertension. 2020;75(3):702-6. Epub 2020/01/14. doi: 10.1161/hypertensionaha.119.14258. (PubMed ID Number: 31928112).
Granot-Hershkovitz E, Wu P, Karasik D, Peter I, Peloso GM, Levy D, Vasan RS, Adrienne Cupples L, Liu CT, Meigs JB, Siscovick DS, Dupuis J, Friedlander Y, Hochner H. Searching for parent-of-origin effects on cardiometabolic traits in imprinted genomic regions. Eur J Hum Genet. 2020;28(5):646-55. Epub 2020/01/04. doi: 10.1038/s41431-019-0568-1. (PubMed ID Number: 31896779).
Ji H, Kim A, Ebinger JE, Niiranen TJ, Claggett BL, Bairey Merz CN, Cheng S. Sex Differences in Blood Pressure Trajectories Over the Life Course. JAMA Cardiol. 2020;5(3):19-26. Epub 2020/01/16. doi: 10.1001/jamacardio.2019.5306. (PubMed ID Number: 31940010; PMCID: PMC6990675).
Kessler MD, Loesch DP, Perry JA, Heard-Costa NL, Taliun D, Cade BE, Wang H, Daya M, Ziniti J, Datta S, Celedón JC, Soto-Quiros ME, Avila L, Weiss ST, Barnes K, Redline SS, Vasan RS, Johnson AD, Mathias RA, Hernandez R, Wilson JG, Nickerson DA, Abecasis G, Browning SR, Zöllner S, O’Connell JR, Mitchell BD, O’Connor TD. De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population. Proc Natl Acad Sci U S A. 2020;117(5):2560-9. Epub 2020/01/23. doi: 10.1073/pnas.1902766117. (PubMed ID Number: 31964835; PMCID: PMC7007577).
Lee CM, Woodward M, Batty GD, Beiser AS, Bell S, Berr C, Bjertness E, Chalmers J, Clarke R, Dartigues JF, Davis-Plourde K, Debette S, Di Angelantonio E, Feart C, Frikke-Schmidt R, Gregson J, Haan MN, Hassing LB, Hayden KM, Hoevenaar-Blom MP, Kaprio J, Kivimaki M, Lappas G, Larson EB, LeBlanc ES, Lee A, Lui LY, Moll van Charante EP, Ninomiya T, Nordestgaard LT, Ohara T, Ohkuma T, Palviainen T, Peres K, Peters R, Qizilbash N, Richard E, Rosengren A, Seshadri S, Shipley M, Singh-Manoux A, Strand BH, van Gool WA, Vuoksimaa E, Yaffe K, Huxley RR. Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia. Obes Rev. 2020;21(4):e12989. Epub 2020/01/04. doi: 10.1111/obr.12989. (PubMed ID Number: 31898862; PMCID: PMC7079047).
McGrath ER, Himali JJ, Xanthakis V, Duncan MS, Schaffer JE, Ory DS, Peterson LR, DeCarli C, Pase MP, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Circulating ceramide ratios and risk of vascular brain aging and dementia. Ann Clin Transl Neurol. 2020;7(2):160-8. Epub 2020/01/18. doi: 10.1002/acn3.50973. (PubMed ID Number: 31950603; PMCID: PMC7034495).
Shah S, Henry A, Roselli C, Lin H, Sveinbjörnsson G, Fatemifar G, Hedman Å K, Wilk JB, Morley MP, Chaffin MD, Helgadottir A, Verweij N, Dehghan A, Almgren P, Andersson C, Aragam KG, Ärnlöv J, Backman JD, Biggs ML, Bloom HL, Brandimarto J, Brown MR, Buckbinder L, Carey DJ, Chasman DI, Chen X, Chen X, Chung J, Chutkow W, Cook JP, Delgado GE, Denaxas S, Doney AS, Dörr M, Dudley SC, Dunn ME, Engström G, Esko T, Felix SB, Finan C, Ford I, Ghanbari M, Ghasemi S, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gutmann R, Haggerty CM, van der Harst P, Hyde CL, Ingelsson E, Jukema JW, Kavousi M, Khaw KT, Kleber ME, Køber L, Koekemoer A, Langenberg C, Lind L, Lindgren CM, London B, Lotta LA, Lovering RC, Luan J, Magnusson P, Mahajan A, Margulies KB, März W, Melander O, Mordi IR, Morgan T, Morris AD, Morris AP, Morrison AC, Nagle MW, Nelson CP, Niessner A, Niiranen T, O’Donoghue ML, Owens AT, Palmer CNA, Parry HM, Perola M, Portilla-Fernandez E, Psaty BM, Rice KM, Ridker PM, Romaine SPR, Rotter JI, Salo P, Salomaa V, van Setten J, Shalaby AA, Smelser DT, Smith NL, Stender S, Stott DJ, Svensson P, Tammesoo ML, Taylor KD, Teder-Laving M, Teumer A, Thorgeirsson G, Thorsteinsdottir U, Torp-Pedersen C, Trompet S, Tyl B, Uitterlinden AG, Veluchamy A, Völker U, Voors AA, Wang X, Wareham NJ, Waterworth D, Weeke PE, Weiss R, Wiggins KL, Xing H, Yerges-Armstrong LM, Yu B, Zannad F, Zhao JH, Hemingway H, Samani NJ, McMurray JJV, Yang J, Visscher PM, Newton-Cheh C, Malarstig A, Holm H, Lubitz SA, Sattar N, Holmes MV, Cappola TP, Asselbergs FW, Hingorani AD, Kuchenbaecker K, Ellinor PT, Lang CC, Stefansson K, Smith JG, Vasan RS, Swerdlow DI, Lumbers RT. Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Nat Commun. 2020;11(1):163. Epub 2020/01/11. doi: 10.1038/s41467-019-13690-5. (PubMed ID Number: 31919418; PMCID: PMC6952380).
Staerk L, Preis SR, Lin H, Lubitz SA, Ellinor PT, Levy D, Benjamin EJ, Trinquart L. Protein Biomarkers and Risk of Atrial Fibrillation: The FHS. Circ Arrhythm Electrophysiol. 2020;13(2):e007607. Epub 2020/01/17. doi: 10.1161/circep.119.007607. (PubMed ID Number: 31941368; PMCID: PMC7031024).
Zhao YQ, Zhu R, Chen G, Zheng Y. Constructing dynamic treatment regimes with shared parameters for censored data. Stat Med. 2020;39(9):1250-63. Epub 2020/01/18. doi: 10.1002/sim.8473. (PubMed ID Number: 31951041).
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February
Agelink van Rentergem JA, de Vent NR, Schmand BA, Murre JMJ, Staaks JPC, Huizenga HM. The Factor Structure of Cognitive Functioning in Cognitively Healthy Participants: a Meta-Analysis and Meta-Analysis of Individual Participant Data. Neuropsychol Rev. 2020;30(1):51-96. Epub 2020/02/03. doi: 10.1007/s11065-019-09423-6. (PubMed ID Number: 32008158; PMCID: PMC7089912).
Arbeev KG, Verhulst S, Steenstrup T, Kark JD, Bagley O, Kooperberg C, Reiner AP, Hwang SJ, Levy D, Fitzpatrick AL, Christensen K, Yashin AI, Aviv A. Association of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies. JAMA Netw Open. 2020;3(2):e200023. Epub 2020/02/27. doi: 10.1001/jamanetworkopen.2020.0023. (PubMed ID Number: 32101305; PMCID: PMC7137690).
Feitosa MF, Lunetta KL, Wang L, Wojczynski MK, Kammerer CM, Perls T, Schupf N, Christensen K, Murabito JM, Province MA. Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies. Atherosclerosis. 2020;297:102-10. Epub 2020/02/29. doi: 10.1016/j.atherosclerosis.2020.02.005. (PubMed ID Number: 32109663).
Friedberg JS, Aytan N, Cherry JD, Xia W, Standring OJ, Alvarez VE, Nicks R, Svirsky S, Meng G, Jun G, Ryu H, Au R, Stein TD. Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype. Sci Rep. 2020;10(1):2924. Epub 2020/02/23. doi: 10.1038/s41598-020-59869-5. (PubMed ID Number: 32076055; PMCID: PMC7031423).
Haslam DE, Peloso GM, Herman MA, Dupuis J, Lichtenstein AH, Smith CE, McKeown NM. Beverage Consumption and Longitudinal Changes in Lipoprotein Concentrations and Incident Dyslipidemia in US Adults: The Framingham Heart Study. J Am Heart Assoc. 2020;9(5):e014083. Epub 2020/02/27. doi: 10.1161/jaha.119.014083. (PubMed ID Number: 32098600).
Hruby A, Dennis C, Jacques PF. Dairy Intake in 2 American Adult Cohorts Associates with Novel and Known Targeted and Nontargeted Circulating Metabolites. J Nutr. 2020. Epub 2020/02/15. doi: 10.1093/jn/nxaa021. (PubMed ID Number: 32055836).
Ji H, Kim A, Ebinger JE, Niiranen TJ, Claggett BL, Merz CNB, Cheng S. Cardiometabolic Risk-Related Blood Pressure Trajectories Differ by Sex. Hypertension. 2020;75(4):e6-e9. Epub 2020/02/18. doi: 10.1161/hypertensionaha.119.14570. (PubMed ID Number: 32063062).
Kulminski AM, Shu L, Loika Y, He L, Nazarian A, Arbeev K, Ukraintseva S, Yashin A, Culminskaya I. Genetic and regulatory architecture of Alzheimer’s disease in the APOE region. Alzheimers Dement (Amst). 2020;12(1):e12008. Epub 2020/03/27. doi: 10.1002/dad2.12008. (PubMed ID Number: 32211503; PMCID: PMC7085286).
Nazarian A, Arbeev KG, Kulminski AM. The impact of disregarding family structure on genome-wide association analysis of complex diseases in cohorts with simple pedigrees. J Appl Genet. 2020;61(1):75-86. Epub 2019/11/23. doi: 10.1007/s13353-019-00526-7. (PubMed ID Number: 31755004; PMCID: PMC6980752).
Nwabuo CC, Vasan RS. Pathophysiology of Hypertensive Heart Disease: Beyond Left Ventricular Hypertrophy. Curr Hypertens Rep. 2020;22(2):11. Epub 2020/02/06. doi: 10.1007/s11906-020-1017-9. (PubMed ID Number: 32016791).
Posner DC, Lin H, Meigs JB, Kolaczyk ED, Dupuis J. Convex combination sequence kernel association test for rare-variant studies. Genet Epidemiol. 2020. Epub 2020/02/27. doi: 10.1002/gepi.22287. (PubMed ID Number: 32100372).
Shishtar E, Rogers GT, Blumberg JB, Au R, Jacques PF. Long-term dietary flavonoid intake and change in cognitive function in the Framingham Offspring cohort. Public Health Nutr. 2020:1-13. Epub 2020/02/25. doi: 10.1017/s136898001900394x. (PubMed ID Number: 32090722).
Wang Y, Beauchamp ME, Abrahamowicz M. Nonlinear and time-dependent effects of sparsely measured continuous time-varying covariates in time-to-event analysis. Biom J. 2020;62(2):492-515. Epub 2020/02/06. doi: 10.1002/bimj.201900042. (PubMed ID Number: 32022299).
Yang T, Wu C, Wei P, Pan W. Integrating DNA sequencing and transcriptomic data for association analyses of low-frequency variants and lipid traits. Hum Mol Genet. 2020;29(3):515-26. Epub 2020/01/11. doi: 10.1093/hmg/ddz314. (PubMed ID Number: 31919517; PMCID: PMC7015848).
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March
Chadid S, Kreger BE, Singer MR, Loring Bradlee M, Moore LL. Anthropometric measures of body fat and obesity-related cancer risk: sex-specific differences in Framingham Offspring Study adults. Int J Obes (Lond). 2020;44(3):601-8. Epub 2020/01/25. doi: 10.1038/s41366-020-0519-5. (PubMed ID Number: 31974408).
Chen HY, Cairns BJ, Small AM, Burr HA, Ambikkumar A, Martinsson A, Thériault S, Munter HM, Steffen B, Zhang R, Levinson RT, Shaffer CM, Rong J, Sonestedt E, Dufresne L, Ljungberg J, Näslund U, Johansson B, Ranatunga DK, Whitmer RA, Budoff MJ, Nguyen A, Vasan RS, Larson MG, Harris WS, Damrauer SM, Stark KD, Boekholdt SM, Wareham NJ, Pibarot P, Arsenault BJ, Mathieu P, Gudnason V, O’Donnell CJ, Rotter JI, Tsai MY, Post WS, Clarke R, Söderberg S, Bossé Y, Wells QS, Smith JG, Rader DJ, Lathrop M, Engert JC, Thanassoulis G. Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis. JAMA Cardiol. 2020;5(6):1-9. Epub 2020/03/19. doi: 10.1001/jamacardio.2020.0246. (PubMed ID Number: 32186652; PMCID: PMC7081150).
Corlin L, Short MI, Vasan RS, Xanthakis V. Association of the Duration of Ideal Cardiovascular Health Through Adulthood With Cardiometabolic Outcomes and Mortality in the Framingham Offspring Study. JAMA Cardiol. 2020;5(5):1-8. Epub 2020/03/12. doi: 10.1001/jamacardio.2020.0109. (PubMed ID Number: 32159731; PMCID: PMC7066529).
Fernández-Sanlés A, Sayols-Baixeras S, Castro DEMM, Esteller M, Subirana I, Torres-Cuevas S, Pérez-Fernández S, Aslibekyan S, Marrugat J, Elosua R. Physical Activity and Genome-wide DNA Methylation: The REgistre GIroní del COR Study. Med Sci Sports Exerc. 2020;52(3):589-97. Epub 2019/10/28. doi: 10.1249/mss.0000000000002174. (PubMed ID Number: 31652233; PMCID: PMC7023998).
Johnson ND, Huang L, Li R, Li Y, Yang Y, Kim HR, Grant C, Wu H, Whitsel EA, Kiel DP, Baccarelli AA, Jin P, Murabito JM, Conneely KN. Age-related DNA hydroxymethylation is enriched for gene expression and immune system processes in human peripheral blood. Epigenetics. 2020;15(3):294-306. Epub 2019/09/12. doi: 10.1080/15592294.2019.1666651. (PubMed ID Number: 31506003; PMCID: PMC7028349).
Osazuwa-Peters OL, Waken RJ, Schwander KL, Sung YJ, de Vries PS, Hartz SM, Chasman DI, Morrison AC, Bierut LJ, Xiong C, de Las Fuentes L, Rao DC. Identifying blood pressure loci whose effects are modulated by multiple lifestyle exposures. Genet Epidemiol. 2020;44(6):629-41. Epub 2020/04/01. doi: 10.1002/gepi.22292. (PubMed ID Number: 32227373).
Ran S, Zhang YX, Liu L, Jiang ZX, He X, Liu Y, Shen H, Tian Q, Pei YF, Deng HW, Zhang L. Association of 3p27.1 Variants with Whole Body Lean Mass Identified by a Genome-wide Association Study. Sci Rep. 2020;10(1):4293. Epub 2020/03/11. doi: 10.1038/s41598-020-61272-z. (PubMed ID Number: 32152362; PMCID: PMC7062907).
Sherer JA, Huang Q, Kiel DP, Benjamin EJ, Trinquart L. Atrial Fibrillation and the Risk of Subsequent Fracture. Am J Med. 2020;133(8):954-60. Epub 2020/03/10. doi: 10.1016/j.amjmed.2020.02.012. (PubMed ID Number: 32147449).
Staerk L, Preis SR, Lin H, Casas JP, Lunetta K, Weng LC, Anderson CD, Ellinor PT, Lubitz SA, Benjamin EJ, Trinquart L. Novel Risk Modeling Approach of Atrial Fibrillation With Restricted Mean Survival Times: Application in the Framingham Heart Study Community-Based Cohort. Circ Cardiovasc Qual Outcomes. 2020;13(4):e005918. Epub 2020/04/02. doi: 10.1161/circoutcomes.119.005918. (PubMed ID Number: 32228064; PMCID: PMC7176529).
Wang EY, Hulme OL, Khurshid S, Weng LC, Choi SH, Walkey AJ, Ashburner JM, McManus DD, Singer DE, Atlas SJ, Benjamin EJ, Ellinor PT, Trinquart L, Lubitz SA. Initial Precipitants and Recurrence of Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2020;13(3):e007716. Epub 2020/02/23. doi: 10.1161/circep.119.007716. (PubMed ID Number: 32078361; PMCID: PMC7141776).
Xu YX, Peloso GM, Nagai TH, Mizoguchi T, Deik A, Bullock K, Lin H, Musunuru K, Yang Q, Vasan RS, Gerszten RE, Clish CB, Rader D, Kathiresan S. EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression. iScience. 2020;23(4):100973. Epub 2020/03/28. doi: 10.1016/j.isci.2020.100973. (PubMed ID Number: 32213464; PMCID: PMC7093811).
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April
Baradaran H, Demissie S, Himali JJ, Beiser A, Gupta A, Polak JF, DeCarli C, Seshadri S, Romero JR. The progression of carotid atherosclerosis and imaging markers of dementia. Alzheimers Dement (N Y). 2020;6(1):e12015. Epub 2020/04/17. doi: 10.1002/trc2.12015. (PubMed ID Number: 32296732; PMCID: PMC7154591).
Brunner KT, Pedley A, Massaro JM, Hoffmann U, Benjamin EJ, Long MT. Increasing liver fat is associated with progression of cardiovascular risk factors. Liver Int. 2020;40(6):1339-43. Epub 2020/04/18. doi: 10.1111/liv.14472. (PubMed ID Number: 32301571).
Chan MV, Chen MH, Barwari T, Huffman JE, Armstrong PC, Hwang SJ, Santer P, Wierer B, Mayr M, Kiechl S, Johnson AD, Willeit J, Warner TD. Platelet Reactivity in Individuals Over 65 Years Old Is Not Modulated by Age. Circ Res. 2020;127(3):394-6. Epub 2020/04/28. doi: 10.1161/circresaha.119.316324. (PubMed ID Number: 32336198; PMCID: PMC7360093).
Ding H, An N, Au R, Devine S, Auerbach SH, Massaro J, Joshi P, Liu X, Liu Y, Mahon E, Ang TF, Lin H. Exploring the Hierarchical Influence of Cognitive Functions for Alzheimer Disease: The Framingham Heart Study. J Med Internet Res. 2020;22(4):e15376. Epub 2020/04/24. doi: 10.2196/15376. (PubMed ID Number: 32324139; PMCID: PMC7206516).
Khurshid S, Trinquart L, Weng LC, Hulme OL, Guan W, Ko D, Schwab K, Rost NS, Al-Alusi MA, Benjamin EJ, Ellinor PT, Anderson CD, Lubitz SA. Atrial Fibrillation Risk and Discrimination of Cardioembolic From Noncardioembolic Stroke. Stroke. 2020;51(5):1396-403. Epub 2020/04/08. doi: 10.1161/strokeaha.120.028837. (PubMed ID Number: 32252601; PMCID: PMC7188588).
Koay YC, Chen YC, Wali JA, Luk AWS, Li M, Doma H, Reimark R, Zaldivia MTK, Habtom HT, Frank AE, Fusco-Allison G, Yang J, Holmes A, Simpson SJ, Peter K, O’Sullivan JF. Plasma Levels of TMAO can be Increased with ‘Healthy’ and ‘Unhealthy’ Diets and Do Not Correlate with the Extent of Atherosclerosis but with Plaque Instability. Cardiovasc Res. 2020. Epub 2020/04/09. doi: 10.1093/cvr/cvaa094. (PubMed ID Number: 32267921).
Ribeiro AH, Maria Pavan Soler J. Learning genetic and environmental graphical models from family data. Stat Med. 2020;39(18):2403-22. Epub 2020/04/30. doi: 10.1002/sim.8545. (PubMed ID Number: 32346898).
Thomas LE, Yang S, Wojdyla D, Schaubel DE. Matching with time-dependent treatments: A review and look forward. Stat Med. 2020;39(17):2350-70. Epub 2020/04/04. doi: 10.1002/sim.8533. (PubMed ID Number: 32242973; PMCID: PMC7384144).
Velagaleti RS, Short MI, Larson MG, Vasan RS. Prognosis of “pre-heart failure” clinical phenotypes. PLoS One. 2020;15(4):e0231254. Epub 2020/04/11. doi: 10.1371/journal.pone.0231254. (PubMed ID Number: 32275698; PMCID: PMC7147998).
Westerman K, Fernández-Sanlés A, Patil P, Sebastiani P, Jacques P, Starr JM, I JD, Liu Q, Liu S, Elosua R, DeMeo DL, Ordovás JM. Epigenomic Assessment of Cardiovascular Disease Risk and Interactions With Traditional Risk Metrics. J Am Heart Assoc. 2020;9(8):e015299. Epub 2020/04/21. doi: 10.1161/jaha.119.015299. (PubMed ID Number: 32308120; PMCID: PMC7428544).
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May
Castro-Diehl C, Song RJ, Mitchell GF, McManus D, Cheng S, Vasan RS, Xanthakis V. Association of subclinical atherosclerosis with echocardiographic indices of cardiac remodeling: The Framingham Study. PLoS One. 2020;15(5):e0233321. Epub 2020/05/16. doi: 10.1371/journal.pone.0233321. (PubMed ID Number: 32413074; PMCID: PMC7228064).
de Las Fuentes L, Sung YJ, Noordam R, Winkler T, Feitosa MF, Schwander K, Bentley AR, Brown MR, Guo X, Manning A, Chasman DI, Aschard H, Bartz TM, Bielak LF, Campbell A, Cheng CY, Dorajoo R, Hartwig FP, Horimoto A, Li C, Li-Gao R, Liu Y, Marten J, Musani SK, Ntalla I, Rankinen T, Richard M, Sim X, Smith AV, Tajuddin SM, Tayo BO, Vojinovic D, Warren HR, Xuan D, Alver M, Boissel M, Chai JF, Chen X, Christensen K, Divers J, Evangelou E, Gao C, Girotto G, Harris SE, He M, Hsu FC, Kühnel B, Laguzzi F, Li X, Lyytikäinen LP, Nolte IM, Poveda A, Rauramaa R, Riaz M, Rueedi R, Shu XO, Snieder H, Sofer T, Takeuchi F, Verweij N, Ware EB, Weiss S, Yanek LR, Amin N, Arking DE, Arnett DK, Bergmann S, Boerwinkle E, Brody JA, Broeckel U, Brumat M, Burke G, Cabrera CP, Canouil M, Chee ML, Chen YI, Cocca M, Connell J, de Silva HJ, de Vries PS, Eiriksdottir G, Faul JD, Fisher V, Forrester T, Fox EF, Friedlander Y, Gao H, Gigante B, Giulianini F, Gu CC, Gu D, Harris TB, He J, Heikkinen S, Heng CK, Hunt S, Ikram MA, Irvin MR, Kähönen M, Kavousi M, Khor CC, Kilpeläinen TO, Koh WP, Komulainen P, Kraja AT, Krieger JE, Langefeld CD, Li Y, Liang J, Liewald DCM, Liu CT, Liu J, Lohman KK, Mägi R, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mook-Kanamori DO, Nalls MA, Nelson CP, Norris JM, O’Connell J, Ogunniyi A, Padmanabhan S, Palmer ND, Pedersen NL, Perls T, Peters A, Petersmann A, Peyser PA, Polasek O, Porteous DJ, Raffel LJ, Rice TK, Rotter JI, Rudan I, Rueda-Ochoa OL, Sabanayagam C, Salako BL, Schreiner PJ, Shikany JM, Sidney SS, Sims M, Sitlani CM, Smith JA, Starr JM, Strauch K, Swertz MA, Teumer A, Tham YC, Uitterlinden AG, Vaidya D, van der Ende MY, Waldenberger M, Wang L, Wang YX, Wei WB, Weir DR, Wen W, Yao J, Yu B, Yu C, Yuan JM, Zhao W, Zonderman AB, Becker DM, Bowden DW, Deary IJ, Dörr M, Esko T, Freedman BI, Froguel P, Gasparini P, Gieger C, Jonas JB, Kammerer CM, Kato N, Lakka TA, Leander K, Lehtimäki T, Magnusson PKE, Marques-Vidal P, Penninx B, Samani NJ, van der Harst P, Wagenknecht LE, Wu T, Zheng W, Zhu X, Bouchard C, Cooper RS, Correa A, Evans MK, Gudnason V, Hayward C, Horta BL, Kelly TN, Kritchevsky SB, Levy D, Palmas WR, Pereira AC, Province MM, Psaty BM, Ridker PM, Rotimi CN, Tai ES, van Dam RM, van Duijn CM, Wong TY, Rice K, Gauderman WJ, Morrison AC, North KE, Kardia SLR, Caulfield MJ, Elliott P, Munroe PB, Franks PW, Rao DC, Fornage M. Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Mol Psychiatry. 2020. Epub 2020/05/07. doi: 10.1038/s41380-020-0719-3. (PubMed ID Number: 32372009).
Himmelreich JCL, Veelers L, Lucassen WAM, Schnabel RB, Rienstra M, van Weert H, Harskamp RE. Prediction models for atrial fibrillation applicable in the community: a systematic review and meta-analysis. Europace. 2020;22(5):684-94. Epub 2020/02/06. doi: 10.1093/europace/euaa005. (PubMed ID Number: 32011689).
Lee J, Vasan RS, Xanthakis V. Association of Blood Pressure Responses to Submaximal Exercise in Midlife With the Incidence of Cardiovascular Outcomes and All-Cause Mortality: The Framingham Heart Study. J Am Heart Assoc. 2020;9(11):e015554. Epub 2020/05/21. doi: 10.1161/jaha.119.015554. (PubMed ID Number: 32431193; PMCID: PMC7428993).
Nayor M, Short MI, Rasheed H, Lin H, Jonasson C, Yang Q, Hveem K, Felix JF, Morrison AC, Wild PS, Morley MP, Cappola TP, Benson MD, Ngo D, Sinha S, Keyes MJ, Shen D, Wang TJ, Larson MG, Brumpton BM, Gerszten RE, Omland T, Vasan RS. Aptamer-Based Proteomic Platform Identifies Novel Protein Predictors of Incident Heart Failure and Echocardiographic Traits. Circ Heart Fail. 2020;13(5):e006749. Epub 2020/05/16. doi: 10.1161/circheartfailure.119.006749. (PubMed ID Number: 32408813; PMCID: PMC7236427).
Nayor M, Xanthakis V, Tanguay M, Blodgett JB, Shah RV, Schoenike M, Sbarbaro J, Farrell R, Malhotra R, Houstis NE, Velagaleti RS, Moore SA, Baggish AL, O’Connor GT, Ho JE, Larson MG, Vasan RS, Lewis GD. Clinical and Hemodynamic Associations and Prognostic Implications of Ventilatory Efficiency in Patients With Preserved Left Ventricular Systolic Function. Circ Heart Fail. 2020;13(5):e006729. Epub 2020/05/05. doi: 10.1161/circheartfailure.119.006729. (PubMed ID Number: 32362167; PMCID: PMC7224335).
Ntalla I, Weng LC, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD, Roselli C, Barnes MR, Mifsud B, Warren HR, Hayward C, Marten J, Cranley JJ, Concas MP, Gasparini P, Boutin T, Kolcic I, Polasek O, Rudan I, Araujo NM, Lima-Costa MF, Ribeiro ALP, Souza RP, Tarazona-Santos E, Giedraitis V, Ingelsson E, Mahajan A, Morris AP, Del Greco MF, Foco L, Gögele M, Hicks AA, Cook JP, Lind L, Lindgren CM, Sundström J, Nelson CP, Riaz MB, Samani NJ, Sinagra G, Ulivi S, Kähönen M, Mishra PP, Mononen N, Nikus K, Caulfield MJ, Dominiczak A, Padmanabhan S, Montasser ME, O’Connell JR, Ryan K, Shuldiner AR, Aeschbacher S, Conen D, Risch L, Thériault S, Hutri-Kähönen N, Lehtimäki T, Lyytikäinen LP, Raitakari OT, Barnes CLK, Campbell H, Joshi PK, Wilson JF, Isaacs A, Kors JA, van Duijn CM, Huang PL, Gudnason V, Harris TB, Launer LJ, Smith AV, Bottinger EP, Loos RJF, Nadkarni GN, Preuss MH, Correa A, Mei H, Wilson J, Meitinger T, Müller-Nurasyid M, Peters A, Waldenberger M, Mangino M, Spector TD, Rienstra M, van de Vegte YJ, van der Harst P, Verweij N, Kääb S, Schramm K, Sinner MF, Strauch K, Cutler MJ, Fatkin D, London B, Olesen M, Roden DM, Benjamin Shoemaker M, Gustav Smith J, Biggs ML, Bis JC, Brody JA, Psaty BM, Rice K, Sotoodehnia N, De Grandi A, Fuchsberger C, Pattaro C, Pramstaller PP, Ford I, Wouter Jukema J, Macfarlane PW, Trompet S, Dörr M, Felix SB, Völker U, Weiss S, Havulinna AS, Jula A, Sääksjärvi K, Salomaa V, Guo X, Heckbert SR, Lin HJ, Rotter JI, Taylor KD, Yao J, de Mutsert R, Maan AC, Mook-Kanamori DO, Noordam R, Cucca F, Ding J, Lakatta EG, Qian Y, Tarasov KV, Levy D, Lin H, Newton-Cheh CH, Lunetta KL, Murray AD, Porteous DJ, Smith BH, Stricker BH, Uitterlinden A, van den Berg ME, Haessler J, Jackson RD, Kooperberg C, Peters U, Reiner AP, Whitsel EA, Alonso A, Arking DE, Boerwinkle E, Ehret GB, Soliman EZ, Avery CL, Gogarten SM, Kerr KF, Laurie CC, Seyerle AA, Stilp A, Assa S, Abdullah Said M, Yldau van der Ende M, Lambiase PD, Orini M, Ramirez J, Van Duijvenboden S, Arnar DO, Gudbjartsson DF, Holm H, Sulem P, Thorleifsson G, Thorolfsdottir RB, Thorsteinsdottir U, Benjamin EJ, Tinker A, Stefansson K, Ellinor PT, Jamshidi Y, Lubitz SA, Munroe PB. Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nat Commun. 2020;11(1):2542. Epub 2020/05/23. doi: 10.1038/s41467-020-15706-x. (PubMed ID Number: 32439900; PMCID: PMC7242331).
Nuotio J, Suvila K, Cheng S, Langén V, Niiranen T. Longitudinal blood pressure patterns and cardiovascular disease risk. Ann Med. 2020;52(3-4):43-54. Epub 2020/02/23. doi: 10.1080/07853890.2020.1733648. (PubMed ID Number: 32077328).
Turkowski KL, Dotzler SM, Tester DJ, Giudicessi JR, Bos JM, Speziale AD, Vollenweider JM, Ackerman MJ. Corrected QT Interval-Polygenic Risk Score and Its Contribution to Type 1, Type 2, and Type 3 Long-QT Syndrome in Probands and Genotype-Positive Family Members). Circ Genom Precis Med. 2020;13(4):e002922. Epub 2020/05/30. doi: 10.1161/circgen.120.002922. (PubMed ID Number: 32469608).
Velagaleti RS, Larson MG, Enserro D, Song RJ, Vasan RS. Clinical course after a first episode of heart failure: insights from the Framingham Heart Study. Eur J Heart Fail. 2020. Epub 2020/05/29. doi: 10.1002/ejhf.1918. (PubMed ID Number: 32462760).
Walker ME, Song RJ, Xu X, Gerszten RE, Ngo D, Clish CB, Corlin L, Ma J, Xanthakis V, Jacques PF, Vasan RS. Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study. Nutrients. 2020;12(5). Epub 2020/05/23. doi: 10.3390/nu12051476. (PubMed ID Number: 32438708; PMCID: PMC7284467).
Williams PT. Spirometric traits show quantile-dependent heritability, which may contribute to their gene-environment interactions with smoking and pollution. PeerJ. 2020;8:e9145. Epub 2020/05/29. doi: 10.7717/peerj.9145. (PubMed ID Number: 32461834; PMCID: PMC7233273).
Wu P, Rybin D, Bielak LF, Feitosa MF, Franceschini N, Li Y, Lu Y, Marten J, Musani SK, Noordam R, Raghavan S, Rose LM, Schwander K, Smith AV, Tajuddin SM, Vojinovic D, Amin N, Arnett DK, Bottinger EP, Demirkan A, Florez JC, Ghanbari M, Harris TB, Launer LJ, Liu J, Liu J, Mook-Kanamori DO, Murray AD, Nalls MA, Peyser PA, Uitterlinden AG, Voortman T, Bouchard C, Chasman D, Correa A, de Mutsert R, Evans MK, Gudnason V, Hayward C, Kao L, Kardia SLR, Kooperberg C, Loos RJF, Province MM, Rankinen T, Redline S, Ridker PM, Rotter JI, Siscovick D, Smith BH, van Duijn C, Zonderman AB, Rao DC, Wilson JG, Dupuis J, Meigs JB, Liu CT, Vassy JL. Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose. PLoS One. 2020;15(5):e0230815. Epub 2020/05/08. doi: 10.1371/journal.pone.0230815. (PubMed ID Number: 32379818; PMCID: PMC7205201).
Yeap BB, Marriott RJ, Adams RJ, Antonio L, Ballantyne CM, Bhasin S, Cawthon PM, Couper DJ, Dobs AS, Flicker L, Karlsson M, Martin SA, Matsumoto AM, Mellström D, Norman PE, Ohlsson C, Orwoll ES, O’Neill TW, Shores MM, Travison TG, Vanderschueren D, Wittert GA, Wu FCW, Murray K. Androgens In Men Study (AIMS): protocol for meta-analyses of individual participant data investigating associations of androgens with health outcomes in men. BMJ Open. 2020;10(5):e034777. Epub 2020/05/14. doi: 10.1136/bmjopen-2019-034777. (PubMed ID Number: 32398333; PMCID: PMC7239545).
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June
Armstrong NJ, Mather KA, Sargurupremraj M, Knol MJ, Malik R, Satizabal CL, Yanek LR, Wen W, Gudnason VG, Dueker ND, Elliott LT, Hofer E, Bis J, Jahanshad N, Li S, Logue MA, Luciano M, Scholz M, Smith AV, Trompet S, Vojinovic D, Xia R, Alfaro-Almagro F, Ames D, Amin N, Amouyel P, Beiser AS, Brodaty H, Deary IJ, Fennema-Notestine C, Gampawar PG, Gottesman R, Griffanti L, Jack CR, Jr., Jenkinson M, Jiang J, Kral BG, Kwok JB, Lampe L, D CML, Maillard P, Marchini J, Bastin ME, Mazoyer B, Pirpamer L, Rafael Romero J, Roshchupkin GV, Schofield PR, Schroeter ML, Stott DJ, Thalamuthu A, Trollor J, Tzourio C, van der Grond J, Vernooij MW, Witte VA, Wright MJ, Yang Q, Morris Z, Siggurdsson S, Psaty B, Villringer A, Schmidt H, Haberg AK, van Duijn CM, Jukema JW, Dichgans M, Sacco RL, Wright CB, Kremen WS, Becker LC, Thompson PM, Mosley TH, Wardlaw JM, Ikram MA, Adams HHH, Seshadri S, Sachdev PS, Smith SM, Launer L, Longstreth W, DeCarli C, Schmidt R, Fornage M, Debette S, Nyquist PA. Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities. Stroke. 2020;51(7):2111-21. Epub 2020/06/11. doi: 10.1161/strokeaha.119.027544. (PubMed ID Number: 32517579; PMCID: PMC7365038).
Chen Y, Peloso GM, Liu CT, DeStefano AL, Dupuis J. Evaluation of population stratification adjustment using genome-wide or exonic variants. Genet Epidemiol. 2020. Epub 2020/07/02. doi: 10.1002/gepi.22332. (PubMed ID Number: 32608112).
Kenny DJ, Plichta DR, Shungin D, Koppel N, Hall AB, Fu B, Vasan RS, Shaw SY, Vlamakis H, Balskus EP, Xavier RJ. Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level. Cell Host Microbe. 2020;28(2):245-57.e6. Epub 2020/06/17. doi: 10.1016/j.chom.2020.05.013. (PubMed ID Number: 32544460; PMCID: PMC7435688).
Kornej J, Börschel CS, Benjamin EJ, Schnabel RB. Epidemiology of Atrial Fibrillation in the 21st Century: Novel Methods and New Insights. Circ Res. 2020;127(1):4-20. Epub 2020/07/28. doi: 10.1161/circresaha.120.316340. (PubMed ID Number: 32716709).
Lee J, Song RJ, Vasan RS, Xanthakis V. Association of Cardiorespiratory Fitness and Hemodynamic Responses to Submaximal Exercise Testing With the Incidence of Chronic Kidney Disease: The Framingham Heart Study. Mayo Clinic proceedings. 2020;95(6):1184-94. Epub 2020/06/06. doi: 10.1016/j.mayocp.2019.11.004. (PubMed ID Number: 32498774).
Lee J, Walker ME, Gabriel KP, Vasan RS, Xanthakis V. Associations of accelerometer-measured physical activity and sedentary time with chronic kidney disease: The Framingham Heart Study. PLoS One. 2020;15(6):e0234825. Epub 2020/06/17. doi: 10.1371/journal.pone.0234825. (PubMed ID Number: 32542048; PMCID: PMC7295223).
Lioutas VA, Beiser AS, Aparicio HJ, Himali JJ, Selim MH, Romero JR, Seshadri S. Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016. JAMA Neurol. 2020. Epub 2020/06/09. doi: 10.1001/jamaneurol.2020.1512. (PubMed ID Number: 32511690; PMCID: PMC7281354).
Liu Y, Shen Y, Guo T, Parnell LD, Westerman KE, Smith CE, Ordovas JM, Lai CQ. Statin Use Associates With Risk of Type 2 Diabetes via Epigenetic Patterns at ABCG1. Front Genet. 2020;11:622. Epub 2020/07/03. doi: 10.3389/fgene.2020.00622. (PubMed ID Number: 32612641; PMCID: PMC7308584).
Ma J, Rebholz CM, Braun KVE, Reynolds LM, Aslibekyan S, Xia R, Biligowda NG, Huan T, Liu C, Mendelson MM, Joehanes R, Hu EA, Vitolins MZ, Wood AC, Lohman K, Ochoa-Rosales C, van Meurs J, Uitterlinden A, Liu Y, Elhadad MA, Heier M, Waldenberger M, Peters A, Colicino E, Whitsel EA, Baldassari A, Gharib SA, Sotoodehnia N, Brody JA, Sitlani CM, Tanaka T, Hill WD, Corley J, Deary IJ, Zhang Y, Schöttker B, Brenner H, Walker ME, Ye S, Nguyen S, Pankow J, Demerath EW, Zheng Y, Hou L, Liang L, Lichtenstein AH, Hu FB, Fornage M, Voortman T, Levy D. Whole Blood DNA Methylation Signatures of Diet Are Associated With Cardiovascular Disease Risk Factors and All-Cause Mortality. Circ Genom Precis Med. 2020;13(4):e002766. Epub 2020/06/12. doi: 10.1161/circgen.119.002766. (PubMed ID Number: 32525743; PMCID: PMC7442697).
Muchira JM, Gona PN, Mogos MF, Stuart-Shor E, Leveille SG, Piano MR, Hayman LL. Temporal Trends and Familial Clustering of Ideal Cardiovascular Health in Parents and Offspring Over the Life Course: An Investigation Using The Framingham Heart Study. J Am Heart Assoc. 2020;9(12):e016292. Epub 2020/06/04. doi: 10.1161/jaha.120.016292. (PubMed ID Number: 32486880; PMCID: PMC7429037).
Qiu S, Joshi PS, Miller MI, Xue C, Zhou X, Karjadi C, Chang GH, Joshi AS, Dwyer B, Zhu S, Kaku M, Zhou Y, Alderazi YJ, Swaminathan A, Kedar S, Saint-Hilaire MH, Auerbach SH, Yuan J, Sartor EA, Au R, Kolachalama VB. Development and validation of an interpretable deep learning framework for Alzheimer’s disease classification. Brain. 2020;143(6):1920-33. Epub 2020/05/02. doi: 10.1093/brain/awaa137. (PubMed ID Number: 32357201; PMCID: PMC7296847).
Raunsø J, Song RJ, Vasan RS, Bourdillon MT, Nørager B, Torp-Pedersen C, Gislason GH, Xanthakis V, Andersson C. Familial Clustering of Aortic Size, Aneurysms, and Dissections in the Community. Circulation. 2020. Epub 2020/06/26. doi: 10.1161/circulationaha.120.045990. (PubMed ID Number: 32580567).
Romero JR, Demissie S, Beiser A, Himali JJ, DeCarli C, Levy D, Seshadri S. Relation of plasma β-amyloid, clusterin, and tau with cerebral microbleeds: Framingham Heart Study. Ann Clin Transl Neurol. 2020;7(7):1083-91. Epub 2020/06/27. doi: 10.1002/acn3.51066. (PubMed ID Number: 32588552; PMCID: PMC7359126).
Schwedhelm E, Song RJ, Vasan RS, van den Heuvel ER, Hannemann J, Xanthakis V, Böger R. Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study. J Clin Med. 2020;9(6). Epub 2020/07/02. doi: 10.3390/jcm9062016. (PubMed ID Number: 32604958; PMCID: PMC7356383).
Shea MK, Barger K, Booth SL, Matuszek G, Cushman M, Benjamin EJ, Kritchevsky SB, Weiner DE. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts. Am J Clin Nutr. 2020;111(6):1170-7. Epub 2020/05/03. doi: 10.1093/ajcn/nqaa082. (PubMed ID Number: 32359159; PMCID: PMC7266692).
Shin J, Ma S, Hofer E, Patel Y, Vosberg DE, Tilley S, Roshchupkin GV, Sousa AMM, Jian X, Gottesman R, Mosley TH, Fornage M, Saba Y, Pirpamer L, Schmidt R, Schmidt H, Carrion-Castillo A, Crivello F, Mazoyer B, Bis JC, Li S, Yang Q, Luciano M, Karama S, Lewis L, Bastin ME, Harris MA, Wardlaw JM, Deary IE, Scholz M, Loeffler M, Witte AV, Beyer F, Villringer A, Armstrong NJ, Mather KA, Ames D, Jiang J, Kwok JB, Schofield PR, Thalamuthu A, Trollor JN, Wright MJ, Brodaty H, Wen W, Sachdev PS, Terzikhan N, Evans TE, Adams H, Ikram MA, Frenzel S, Auwera-Palitschka SV, Wittfeld K, Bülow R, Grabe HJ, Tzourio C, Mishra A, Maingault S, Debette S, Gillespie NA, Franz CE, Kremen WS, Ding L, Jahanshad N, Sestan N, Pausova Z, Seshadri S, Paus T. Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes. Cereb Cortex. 2020;30(7):4121-39. Epub 2020/03/22. doi: 10.1093/cercor/bhaa035. (PubMed ID Number: 32198502).
Shishtar E, Rogers GT, Blumberg JB, Au R, DeCarli C, Jacques PF. Flavonoid Intake and MRI Markers of Brain Health in the Framingham Offspring Cohort. J Nutr. 2020;150(6):1545-53. Epub 2020/03/27. doi: 10.1093/jn/nxaa068. (PubMed ID Number: 32211795; PMCID: PMC7269753).
Smit RAJ, Trompet S, Leong A, Goodarzi MO, Postmus I, Warren H, Theusch E, Barnes MR, Arsenault BJ, Li X, Feng Q, Chasman DI, Cupples LA, Hitman GA, Krauss RM, Psaty BM, Rotter JI, Cessie SL, Stein CM, Jukema JW. Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study. Pharmacogenomics J. 2020;20(3):462-70. Epub 2019/12/06. doi: 10.1038/s41397-019-0125-x. (PubMed ID Number: 31801993; PMCID: PMC7260089).
Sofer T, Li R, Joehanes R, Lin H, Gower AC, Wang H, Kurniansyah N, Cade BE, Lee J, Williams S, Mehra R, Patel SR, Quan SF, Liu Y, Rotter JI, Rich SS, Spira A, Levy D, Gharib SA, Redline S, Gottlieb DJ. Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy. EBioMedicine. 2020;56:102803. Epub 2020/06/09. doi: 10.1016/j.ebiom.2020.102803. (PubMed ID Number: 32512511; PMCID: PMC7276515).
Wang Z, Chen H, Bartz TM, Bielak LF, Chasman DI, Feitosa MF, Franceschini N, Guo X, Lim E, Noordam R, Richard MA, Wang H, Cade B, Cupples LA, de Vries PS, Giulanini F, Lee J, Lemaitre RN, Martin LW, Reiner AP, Rich SS, Schreiner PJ, Sidney S, Sitlani CM, Smith JA, Willems van Dijk K, Yao J, Zhao W, Fornage M, Kardia SLR, Kooperberg C, Liu CT, Mook-Kanamori DO, Province MA, Psaty BM, Redline S, Ridker PM, Rotter JI, Boerwinkle E, Morrison AC. Role of Rare and Low-Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels. Circ Genom Precis Med. 2020;13(4):e002772. Epub 2020/06/09. doi:10.1161/circgen.119.002772. (PubMed ID Number: 32510982; PMCID: PMC7442680).
Zhou X, Wang M, Lin S. Detecting rare haplotypes associated with complex diseases using both population and family data: Combined logistic Bayesian Lasso. Stat Methods Med Res. 2020:962280220927728. Epub 2020/06/05. doi: 10.1177/0962280220927728. (PubMed ID Number: 32493129).
Zhou Y, Browning BL, Browning SR. Population-Specific Recombination Maps from Segments of Identity by Descent. Am J Hum Genet. 2020;107(1):137-48. Epub 2020/06/14. doi: 10.1016/j.ajhg.2020.05.016. (PubMed ID Number: 32533945; PMCID: PMC7332656).
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July
Chiu LS, Pedley A, Massaro JM, Benjamin EJ, Mitchell GF, McManus DD, Aragam J, Vasan RS, Cheng S, Long MT. The association of non-alcoholic fatty liver disease and cardiac structure and function-Framingham Heart Study. Liver Int. 2020. Epub 2020/07/13. doi: 10.1111/liv.14600. (PubMed ID Number: 32654390).
Colicino E, Marioni R, Ward-Caviness C, Gondalia R, Guan W, Chen B, Tsai PC, Huan T, Xu G, Golareh A, Schwartz J, Vokonas P, Just A, Starr JM, McRae AF, Wray NR, Visscher PM, Bressler J, Zhang W, Tanaka T, Moore AZ, Pilling LC, Zhang G, Stewart JD, Li Y, Hou L, Castillo-Fernandez J, Spector T, Kiel DP, Murabito JM, Liu C, Mendelson M, Assimes T, Absher D, Tsaho PS, Lu AT, Ferrucci L, Wilson R, Waldenberger M, Prokisch H, Bandinelli S, Bell JT, Levy D, Deary IJ, Horvath S, Pankow J, Peters A, Whitsel EA, Baccarelli A. Blood DNA methylation sites predict death risk in a longitudinal study of 12, 300 individuals. Aging. 2020;12(14):14092-124. Epub 2020/07/23. doi: 10.18632/aging.103408. (PubMed ID Number: 32697766; PMCID: PMC7425458).
Ji-Xu A, Yang Y, Bradley KM. Pulmonary artery enlargement on routine staging (18)F-fluodeoxyglucose positron emission tomography/CT for lung and oesophageal cancer. Br J Radiol. 2020;93(1113):20200323. Epub 2020/06/26. doi: 10.1259/bjr.20200323. (PubMed ID Number: 32584599).
Ludwig-Słomczyńska AH, Seweryn MT, Kapusta P, Pitera E, Handelman SK, Mantaj U, Cyganek K, Gutaj P, Dobrucka Ł, Wender-Ożegowska E, Małecki MT, Wołkow PP. Mitochondrial GWAS and association of nuclear – mitochondrial epistasis with BMI in T1DM patients. BMC Med Genomics. 2020;13(1):97. Epub 2020/07/09. doi: 10.1186/s12920-020-00752-7. (PubMed ID Number: 32635923; PMCID: PMC7341625).
Peloso GM, Beiser AS, Satizabal CL, Xanthakis V, Vasan RS, Pase MP, Destefano AL, Seshadri S. Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study. Neurology. 2020. Epub 2020/07/22. doi: 10.1212/wnl.0000000000010306. (PubMed ID Number: 32690788).
Petrea RE, O’Donnell A, Beiser AS, Habes M, Aparicio H, DeCarli C, Seshadri S, Romero JR. Mid to Late Life Hypertension Trends and Cerebral Small Vessel Disease in the Framingham Heart Study. Hypertension. 2020;76(3):707-14. Epub 2020/08/07. doi: 10.1161/hypertensionaha.120.15073. (PubMed ID Number: 32755403).
Rodriguez BAT, Johnson AD. Platelet Measurements and Type 2 Diabetes: Investigations in Two Population-Based Cohorts. Front Cardiovasc Med. 2020;7:118. Epub 2020/08/06. doi: 10.3389/fcvm.2020.00118. (PubMed ID Number: 32754618; PMCID: PMC7365849).
Swayambunathan J, Dasgupta A, Rosenberg PS, Hannan MT, Kiel DP, Bhattacharyya T. Incidence of Hip Fracture Over 4 Decades in the Framingham Heart Study. JAMA Intern Med. 2020. Epub 2020/07/31. doi: 10.1001/jamainternmed.2020.2975. (PubMed ID Number: 32730556; PMCID: PMC7385683).
Wali JA, Koay YC, Chami J, Wood C, Corcilius L, Payne RJ, Rodionov RN, Birkenfeld AL, Samocha-Bonet D, Simpson SJ, O’Sullivan JF. Nutritional and metabolic regulation of the metabolite dimethylguanidino valeric acid: an early marker of cardiometabolic disease. Am J Physiol Endocrinol Metab. 2020;319(3):E509-e18. Epub 2020/07/15. doi: 10.1152/ajpendo.00207.2020. (PubMed ID Number: 32663097).
Williams PT. Quantile-dependent heritability of computed tomography, dual-energy x-ray absorptiometry, anthropometric, and bioelectrical measures of adiposity. Int J Obes (Lond). 2020. Epub 2020/07/16. doi: 10.1038/s41366-020-0636-1. (PubMed ID Number: 32665611).
Wolters FJ, Chibnik LB, Waziry R, Anderson R, Berr C, Beiser A, Bis JC, Blacker D, Bos D, Brayne C, Dartigues JF, Darweesh SKL, Davis-Plourde KL, de Wolf F, Debette S, Dufouil C, Fornage M, Goudsmit J, Grasset L, Gudnason V, Hadjichrysanthou C, Helmer C, Ikram MA, Ikram MK, Joas E, Kern S, Kuller LH, Launer L, Lopez OL, Matthews FE, McRae-McKee K, Meirelles O, Mosley TH, Jr., Pase MP, Psaty BM, Satizabal CL, Seshadri S, Skoog I, Stephan BCM, Wetterberg H, Wong MM, Zettergren A, Hofman A. Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium. Neurology. 2020;95(5):e519-e31. Epub 2020/07/03. doi: 10.1212/wnl.0000000000010022. (PubMed ID Number: 32611641).
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August
Baril AA, Beiser AS, Redline S, McGrath ER, Aparicio HJ, Gottlieb DJ, Seshadri S, Pase MP, Himali JJ. Systemic Inflammation as a Moderator Between Sleep and Incident Dementia. Sleep. 2020. Epub 2020/08/30. doi: 10.1093/sleep/zsaa164. (PubMed ID Number: 32860698).
Kim JS, Steffen BT, Podolanczuk AJ, Kawut SM, Noth I, Raghu G, Michos ED, Hoffman EA, Axelsson GT, Gudmundsson G, Gudnason V, Gudmundsson EF, Murphy RA, Dupuis J, Xu H, Vasan RS, O’Connor GT, Harris WS, Hunninghake GM, Barr RG, Tsai MY, Lederer DJ. Associations of Omega-3 Fatty acids with Interstitial Lung Disease and Lung Imaging Abnormalities Among Adults. Am J Epidemiol. 2020. Epub 2020/08/18. doi: 10.1093/aje/kwaa168. (PubMed ID Number: 32803215).
Lee DH, Yao C, Bhan A, Schlaeger TM, Keefe J, Rodriguez BA, Hwang SJ, Chen MH, Levy D, Johnson AD. Integrative Genomic Analysis Reveals Four Protein Biomarkers for Platelet Traits. Circ Res. 2020. Epub 2020/08/13. doi: 10.1161/circresaha.119.316447. (PubMed ID Number: 32781905).
Li X, Li Z, Zhou H, Gaynor SM, Liu Y, Chen H, Sun R, Dey R, Arnett DK, Aslibekyan S, Ballantyne CM, Bielak LF, Blangero J, Boerwinkle E, Bowden DW, Broome JG, Conomos MP, Correa A, Cupples LA, Curran JE, Freedman BI, Guo X, Hindy G, Irvin MR, Kardia SLR, Kathiresan S, Khan AT, Kooperberg CL, Laurie CC, Liu XS, Mahaney MC, Manichaikul AW, Martin LW, Mathias RA, McGarvey ST, Mitchell BD, Montasser ME, Moore JE, Morrison AC, O’Connell JR, Palmer ND, Pampana A, Peralta JM, Peyser PA, Psaty BM, Redline S, Rice KM, Rich SS, Smith JA, Tiwari HK, Tsai MY, Vasan RS, Wang FF, Weeks DE, Weng Z, Wilson JG, Yanek LR, Neale BM, Sunyaev SR, Abecasis GR, Rotter JI, Willer CJ, Peloso GM, Natarajan P, Lin X. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nat Genet. 2020;52(9):969-83. Epub 2020/08/26. doi: 10.1038/s41588-020-0676-4. (PubMed ID Number: 32839606; PMCID: PMC7483769).
Lin H, Sardana M, Zhang Y, Liu C, Trinquart L, Benjamin EJ, Manders ES, Fusco K, Kornej J, Hammond MM, Spartano NL, Pathiravasan CH, Kheterpal V, Nowak C, Borrelli B, Murabito JM, McManus DD. Association of Habitual Physical Activity with Cardiovascular Disease Risk. Circ Res. 2020. Epub 2020/08/28. doi: 10.1161/circresaha.120.317578. (PubMed ID Number: 32842915).
Matsouaka RA, Atem FD. Regression with a right-censored predictor using inverse probability weighting methods. Stat Med. 2020. Epub 2020/08/12. doi: 10.1002/sim.8704. (PubMed ID Number: 32779274).
Rodriguez BAT, Bhan A, Beswick A, Elwood PC, Niiranen TJ, Salomaa V, Trégouët DA, Morange PE, Civelek M, Ben-Shlomo Y, Schlaeger T, Chen MH, Johnson AD. A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling. Am J Hum Genet. 2020;107(2):211-21. Epub 2020/07/11. doi: 10.1016/j.ajhg.2020.06.008. (PubMed ID Number: 32649856; PMCID: PMC7413854).
Sanborn V, Preis SR, Ang A, Devine S, Mez J, DeCarli C, Au R, Alosco ML, Gunstad J. Association Between Leptin, Cognition, and Structural Brain Measures Among “Early” Middle-Aged Adults: Results from the Framingham Heart Study Third Generation Cohort. J Alzheimers Dis. 2020. Epub 2020/08/25. doi: 10.3233/jad-191247. (PubMed ID Number: 32831199).
Shishtar E, Rogers GT, Blumberg JB, Au R, Jacques PF. Long-term dietary flavonoid intake and risk of Alzheimer disease and related dementias in the Framingham Offspring Cohort. Am J Clin Nutr. 2020;112(2):343-53. Epub 2020/04/23. doi: 10.1093/ajcn/nqaa079. (PubMed ID Number: 32320019; PMCID: PMC7398772).
Suvila K, Langén V, Cheng S, Niiranen TJ. Age of Hypertension Onset: Overview of Research and How to Apply in Practice. Curr Hypertens Rep. 2020;22(9):68. Epub 2020/08/28. doi: 10.1007/s11906-020-01071-z. (PubMed ID Number: 32852608; PMCID: PMC7452883).
Synn AJ, Li W, Hunninghake GM, Washko GR, San José Estépar R, O’Connor GT, Kholdani CA, Hallowell RW, Bankier AA, Mittleman MA, Rice MB. Vascular Pruning on Computed Tomography and Interstitial Lung Abnormalities in the Framingham Heart Study. Chest. 2020. Epub 2020/08/18. doi: 10.1016/j.chest.2020.07.082. (PubMed ID Number: 32798523).
Vaze A, Tran KV, Tanriverdi K, Sardana M, Lessard D, Donahue JK, Barton B, Aurigemma G, Lubitz SA, Lin H, Nasr GH, Mandapati A, Benjamin EJ, Vasan RS, Freedman JE, McManus DD. Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study. PLoS One. 2020;15(8):e0236960. Epub 2020/08/20. doi: 10.1371/journal.pone.0236960. (PubMed ID Number: 32813736; PMCID: PMC7437902).
Vinter N, Huang Q, Fenger-Grøn M, Frost L, Benjamin EJ, Trinquart L. Trends in excess mortality associated with atrial fibrillation over 45 years (Framingham Heart Study): community based cohort study. BMJ. 2020;370:m2724. Epub 2020/08/14. doi: 10.1136/bmj.m2724. (PubMed ID Number: 32784208; PMCID: PMC7418071).
Weng LC, Hall AW, Choi SH, Jurgens SJ, Haessler J, Bihlmeyer NA, Grarup N, Lin H, Teumer A, Li-Gao R, Yao J, Guo X, Brody JA, Müller-Nurasyid M, Schramm K, Verweij N, van den Berg ME, van Setten J, Isaacs A, Ramírez J, Warren HR, Padmanabhan S, Kors JA, de Boer RA, van der Meer P, Sinner MF, Waldenberger M, Psaty BM, Taylor KD, Völker U, Kanters JK, Li M, Alonso A, Perez MV, Vaartjes I, Bots ML, Huang PL, Heckbert SR, Lin HJ, Kornej J, Munroe PB, van Duijn CM, Asselbergs FW, Stricker BH, van der Harst P, Kääb S, Peters A, Sotoodehnia N, Rotter JI, Mook-Kanamori DO, Dörr M, Felix SB, Linneberg A, Hansen T, Arking DE, Kooperberg C, Benjamin EJ, Lunetta KL, Ellinor PT, Lubitz SA. Genetic Determinants of Electrocardiographic P-wave Duration and Relation to Atrial Fibrillation. Circ Genom Precis Med. 2020. Epub 2020/08/22. doi: 10.1161/circgen.119.002874. (PubMed ID Number: 32822252).
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September
Afshar M, Rong J, Zhan Y, Chen HY, Engert JC, Sniderman AD, Larson MG, Vasan RS, Thanassoulis G. Risks of Incident Cardiovascular Disease Associated With Concomitant Elevations in Lipoprotein(a) and Low-Density Lipoprotein Cholesterol-The Framingham Heart Study. J Am Heart Assoc. 2020;9(18):e014711. Epub 2020/09/08. doi: 10.1161/jaha.119.014711. (PubMed ID Number: 32892691).
Andersson C, Liu C, Cheng S, Wang TJ, Gerszten RE, Larson MG, Vasan RS. Metabolomic signatures of cardiac remodelling and heart failure risk in the community. ESC Heart Fail. 2020. Epub 2020/09/11. doi: 10.1002/ehf2.12923. (PubMed ID Number: 32909388).
Araki T, Washko GR, Schiebler ML, O’Connor GT, Hatabu H. The Framingham Heart Study: Populational CT-based phenotyping in the lungs and mediastinum. Eur J Radiol Open. 2020;7:100260. Epub 2020/09/29. doi: 10.1016/j.ejro.2020.100260. (PubMed ID Number: 32984450; PMCID: PMC7495061).
Castellani CA, Longchamps RJ, Sumpter JA, Newcomb CE, Lane JA, Grove ML, Bressler J, Brody JA, Floyd JS, Bartz TM, Taylor KD, Wang P, Tin A, Coresh J, Pankow JS, Fornage M, Guallar E, O’Rourke B, Pankratz N, Liu C, Levy D, Sotoodehnia N, Boerwinkle E, Arking DE. Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs. Genome Med. 2020;12(1):84. Epub 2020/09/30. doi: 10.1186/s13073-020-00778-7. (PubMed ID Number: 32988399; PMCID: PMC7523322z).
Chen MH, Raffield LM, Mousas A, Sakaue S, Huffman JE, Moscati A, Trivedi B, Jiang T, Akbari P, Vuckovic D, Bao EL, Zhong X, Manansala R, Laplante V, Chen M, Lo KS, Qian H, Lareau CA, Beaudoin M, Hunt KA, Akiyama M, Bartz TM, Ben-Shlomo Y, Beswick A, Bork-Jensen J, Bottinger EP, Brody JA, van Rooij FJA, Chitrala K, Cho K, Choquet H, Correa A, Danesh J, Di Angelantonio E, Dimou N, Ding J, Elliott P, Esko T, Evans MK, Floyd JS, Broer L, Grarup N, Guo MH, Greinacher A, Haessler J, Hansen T, Howson JMM, Huang QQ, Huang W, Jorgenson E, Kacprowski T, Kähönen M, Kamatani Y, Kanai M, Karthikeyan S, Koskeridis F, Lange LA, Lehtimäki T, Lerch MM, Linneberg A, Liu Y, Lyytikäinen LP, Manichaikul A, Martin HC, Matsuda K, Mohlke KL, Mononen N, Murakami Y, Nadkarni GN, Nauck M, Nikus K, Ouwehand WH, Pankratz N, Pedersen O, Preuss M, Psaty BM, Raitakari OT, Roberts DJ, Rich SS, Rodriguez BAT, Rosen JD, Rotter JI, Schubert P, Spracklen CN, Surendran P, Tang H, Tardif JC, Trembath RC, Ghanbari M, Völker U, Völzke H, Watkins NA, Zonderman AB, Wilson PWF, Li Y, Butterworth AS, Gauchat JF, Chiang CWK, Li B, Loos RJF, Astle WJ, Evangelou E, van Heel DA, Sankaran VG, Okada Y, Soranzo N, Johnson AD, Reiner AP, Auer PL, Lettre G. Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations. Cell. 2020;182(5):1198-213.e14. Epub 2020/09/06. doi: 10.1016/j.cell.2020.06.045. (PubMed ID Number: 32888493; PMCID: PMC7480402).
Garg P, Jadhav B, Rodriguez OL, Patel N, Martin-Trujillo A, Jain M, Metsu S, Olsen H, Paten B, Ritz B, Kooy RF, Gecz J, Sharp AJ. A Survey of Rare Epigenetic Variation in 23,116 Human Genomes Identifies Disease-Relevant Epivariations and CGG Expansions. Am J Hum Genet. 2020;107(4):654-69. Epub 2020/09/17. doi: 10.1016/j.ajhg.2020.08.019. (PubMed ID Number: 32937144; PMCID: PMC7536611).
Hofer E, Roshchupkin GV, Adams HHH, Knol MJ, Lin H, Li S, Zare H, Ahmad S, Armstrong NJ, Satizabal CL, Bernard M, Bis JC, Gillespie NA, Luciano M, Mishra A, Scholz M, Teumer A, Xia R, Jian X, Mosley TH, Saba Y, Pirpamer L, Seiler S, Becker JT, Carmichael O, Rotter JI, Psaty BM, Lopez OL, Amin N, van der Lee SJ, Yang Q, Himali JJ, Maillard P, Beiser AS, DeCarli C, Karama S, Lewis L, Harris M, Bastin ME, Deary IJ, Veronica Witte A, Beyer F, Loeffler M, Mather KA, Schofield PR, Thalamuthu A, Kwok JB, Wright MJ, Ames D, Trollor J, Jiang J, Brodaty H, Wen W, Vernooij MW, Hofman A, Uitterlinden AG, Niessen WJ, Wittfeld K, Bülow R, Völker U, Pausova Z, Bruce Pike G, Maingault S, Crivello F, Tzourio C, Amouyel P, Mazoyer B, Neale MC, Franz CE, Lyons MJ, Panizzon MS, Andreassen OA, Dale AM, Logue M, Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Stein JL, Thompson PM, Medland SE, Sachdev PS, Kremen WS, Wardlaw JM, Villringer A, van Duijn CM, Grabe HJ, Longstreth WT, Jr., Fornage M, Paus T, Debette S, Arfan Ikram M, Schmidt H, Schmidt R, Seshadri S. Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nat Commun. 2020;11(1):4796. Epub 2020/09/24. doi: 10.1038/s41467-020-18367-y. (PubMed ID Number: 32963231; PMCID: PMC7508833).
Hruby A, Jacques PF. Protein Intake and Human Health: Implications of Units of Protein Intake. Adv Nutr. 2020. Epub 2020/09/04. doi: 10.1093/advances/nmaa097. (PubMed ID Number: 32879937).
Justice AE, Chittoor G, Gondalia R, Melton PE, Lim E, Grove ML, Whitsel EA, Liu CT, Cupples LA, Fernandez-Rhodes L, Guan W, Bressler J, Fornage M, Boerwinkle E, Li Y, Demerath E, Heard-Costa N, Levy D, Stewart JD, Baccarelli A, Hou L, Conneely K, Mori TA, Beilin LJ, Huang RC, Gordon-Larsen P, Howard AG, North KE. Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems. Epigenomics. 2020;12(17):1483-99. Epub 2020/09/10. doi: 10.2217/epi-2019-0276. (PubMed ID Number: 32901515).
Lai CQ, Parnell LD, Smith CE, Guo T, Sayols-Baixeras S, Aslibekyan S, Tiwari HK, Irvin MR, Bender C, Fei D, Hidalgo B, Hopkins PN, Absher DM, Province MA, Elosua R, Arnett DK, Ordovas JM. Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A. Am J Clin Nutr. 2020. Epub 2020/09/16. doi: 10.1093/ajcn/nqaa233. (PubMed ID Number: 32930325).
Lieb W, Song RJ, Vasan RS, Xanthakis V. Premature Parental Cardiovascular Disease and Subclinical Disease Burden in the Offspring. J Am Heart Assoc. 2020;9(18):e015406. Epub 2020/09/09. doi: 10.1161/jaha.119.015406. (PubMed ID Number: 32896212).
McGrath ER, Himali JJ, Levy D, Conner SC, DeCarli C, Pase MP, Ninomiya T, Ohara T, Courchesne P, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Growth Differentiation Factor 15 and NT-proBNP as Blood-Based Markers of Vascular Brain Injury and Dementia. J Am Heart Assoc. 2020;9(19):e014659. Epub 2020/09/15. doi: 10.1161/jaha.119.014659. (PubMed ID Number: 32921207).
Nayor M, Shah RV, Miller PE, Blodgett JB, Tanguay M, Pico AR, Murthy VL, Malhotra R, Houstis NE, Deik A, Pierce KA, Bullock K, Dailey L, Velagaleti RS, Moore SA, Ho JE, Baggish AL, Clish CB, Larson MG, Vasan RS, Lewis GD. Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community. Circulation. 2020. Epub 2020/09/16. doi: 10.1161/circulationaha.120.050281. (PubMed ID Number: 32927962).
Ngo D, Wen D, Gao Y, Keyes MJ, Drury ER, Katz DH, Benson MD, Sinha S, Shen D, Farrell LA, Peterson BD, Friedman DJ, Elmariah S, Young BA, Smith JG, Yang Q, Vasan RS, Larson MG, Correa A, Humphreys BD, Wang TJ, Pollak MR, Wilson JG, Gerszten RE, Rhee EP. Circulating testican-2 is a podocyte-derived marker of kidney health. Proc Natl Acad Sci U S A. 2020;117(40):25026-35. Epub 2020/09/23. doi: 10.1073/pnas.2009606117. (PubMed ID Number: 32958645; PMCID: PMC7547280).
Palmu J, Watrous JD, Mercader K, Havulinna AS, Lagerborg KA, Salosensaari A, Inouye M, Larson MG, Rong J, Vasan RS, Lahti L, Andres A, Cheng S, Jousilahti P, Salomaa V, Jain M, Niiranen TJ. Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population. J Am Heart Assoc. 2020;9(19):e017598. Epub 2020/09/26. doi: 10.1161/jaha.120.017598. (PubMed ID Number: 32975162).
Parekh N, Lin Y, Chan M, Juul F, Makarem N. Longitudinal dimensions of alcohol consumption and dietary intake in the Framingham Heart Study Offspring Cohort (1971-2008). Br J Nutr. 2020:1-10. Epub 2020/09/10. doi: 10.1017/s0007114520002676. (PubMed ID Number: 32900412).
Suthahar N, Lau ES, Blaha MJ, Paniagua SM, Larson MG, Psaty BM, Benjamin EJ, Allison MA, Bartz TM, Januzzi JL, Jr., Levy D, Meems LMG, Bakker SJL, Lima JAC, Cushman M, Lee DS, Wang TJ, deFilippi CR, Herrington DM, Nayor M, Vasan RS, Gardin JM, Kizer JR, Bertoni AG, Allen NB, Gansevoort RT, Shah SJ, Gottdiener JS, Ho JE, de Boer RA. Sex-Specific Associations of Cardiovascular Risk Factors and Biomarkers With Incident Heart Failure. J Am Coll Cardiol. 2020;76(12):1455-65. Epub 2020/09/19. doi: 10.1016/j.jacc.2020.07.044. (PubMed ID Number: 32943164; PMCID: PMC7493711).
Vuckovic D, Bao EL, Akbari P, Lareau CA, Mousas A, Jiang T, Chen MH, Raffield LM, Tardaguila M, Huffman JE, Ritchie SC, Megy K, Ponstingl H, Penkett CJ, Albers PK, Wigdor EM, Sakaue S, Moscati A, Manansala R, Lo KS, Qian H, Akiyama M, Bartz TM, Ben-Shlomo Y, Beswick A, Bork-Jensen J, Bottinger EP, Brody JA, van Rooij FJA, Chitrala KN, Wilson PWF, Choquet H, Danesh J, Di Angelantonio E, Dimou N, Ding J, Elliott P, Esko T, Evans MK, Felix SB, Floyd JS, Broer L, Grarup N, Guo MH, Guo Q, Greinacher A, Haessler J, Hansen T, Howson JMM, Huang W, Jorgenson E, Kacprowski T, Kähönen M, Kamatani Y, Kanai M, Karthikeyan S, Koskeridis F, Lange LA, Lehtimäki T, Linneberg A, Liu Y, Lyytikäinen LP, Manichaikul A, Matsuda K, Mohlke KL, Mononen N, Murakami Y, Nadkarni GN, Nikus K, Pankratz N, Pedersen O, Preuss M, Psaty BM, Raitakari OT, Rich SS, Rodriguez BAT, Rosen JD, Rotter JI, Schubert P, Spracklen CN, Surendran P, Tang H, Tardif JC, Ghanbari M, Völker U, Völzke H, Watkins NA, Weiss S, Cai N, Kundu K, Watt SB, Walter K, Zonderman AB, Cho K, Li Y, Loos RJF, Knight JC, Georges M, Stegle O, Evangelou E, Okada Y, Roberts DJ, Inouye M, Johnson AD, Auer PL, Astle WJ, Reiner AP, Butterworth AS, Ouwehand WH, Lettre G, Sankaran VG, Soranzo N. The Polygenic and Monogenic Basis of Blood Traits and Diseases. Cell. 2020;182(5):1214-31.e11. Epub 2020/09/06. doi: 10.1016/j.cell.2020.08.008. (PubMed ID Number: 32888494; PMCID: PMC7482360).
Walker ME, Xanthakis V, Peterson LR, Duncan MS, Lee J, Ma J, Bigornia S, Moore LL, Quatromoni PA, Vasan RS, Jacques PF. Dietary Patterns, Ceramide Ratios, and Risk of All-Cause and Cause-Specific Mortality: The Framingham Offspring Study. J Nutr. 2020. Epub 2020/09/18. doi: 10.1093/jn/nxaa269. (PubMed ID Number: 32939554).
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October
Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, Szeto MD, Liao X, Leventhal MJ, Nasser J, Chang K, Laurie C, Burugula BB, Gibson CJ, Lin AE, Taub MA, Aguet F, Ardlie K, Mitchell BD, Barnes KC, Moscati A, Fornage M, Redline S, Psaty BM, Silverman EK, Weiss ST, Palmer ND, Vasan RS, Burchard EG, Kardia SLR, He J, Kaplan RC, Smith NL, Arnett DK, Schwartz DA, Correa A, de Andrade M, Guo X, Konkle BA, Custer B, Peralta JM, Gui H, Meyers DA, McGarvey ST, Chen IY, Shoemaker MB, Peyser PA, Broome JG, Gogarten SM, Wang FF, Wong Q, Montasser ME, Daya M, Kenny EE, North KE, Launer LJ, Cade BE, Bis JC, Cho MH, Lasky-Su J, Bowden DW, Cupples LA, Mak ACY, Becker LC, Smith JA, Kelly TN, Aslibekyan S, Heckbert SR, Tiwari HK, Yang IV, Heit JA, Lubitz SA, Johnsen JM, Curran JE, Wenzel SE, Weeks DE, Rao DC, Darbar D, Moon JY, Tracy RP, Buth EJ, Rafaels N, Loos RJF, Durda P, Liu Y, Hou L, Lee J, Kachroo P, Freedman BI, Levy D, Bielak LF, Hixson JE, Floyd JS, Whitsel EA, Ellinor PT, Irvin MR, Fingerlin TE, Raffield LM, Armasu SM, Wheeler MM, Sabino EC, Blangero J, Williams LK, Levy BD, Sheu WH, Roden DM, Boerwinkle E, Manson JE, Mathias RA, Desai P, Taylor KD, Johnson AD, Auer PL, Kooperberg C, Laurie CC, Blackwell TW, Smith AV, Zhao H, Lange E, Lange L, Rich SS, Rotter JI, Wilson JG, Scheet P, Kitzman JO, Lander ES, Engreitz JM, Ebert BL, Reiner AP, Jaiswal S, Abecasis G, Sankaran VG, Kathiresan S, Natarajan P. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020;586(7831):763-8. Epub 2020/10/16. doi: 10.1038/s41586-020-2819-2. (PubMed ID Number: 33057201).
Boer CG, Yau MS, Rice SJ, Coutinho de Almeida R, Cheung K, Styrkarsdottir U, Southam L, Broer L, Wilkinson JM, Uitterlinden AG, Zeggini E, Felson D, Loughlin J, Young M, Capellini TD, Meulenbelt I, van Meurs JB. Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene. Ann Rheum Dis. 2020. Epub 2020/10/16. doi: 10.1136/annrheumdis-2020-217834. (PubMed ID Number: 33055079).
Echouffo-Tcheugui JB, Niiranen TJ, McCabe EL, Henglin M, Jain M, Vasan RS, Larson MG, Cheng S. An Early-Onset Subgroup of Type 2 Diabetes: A Multigenerational, Prospective Analysis in the Framingham Heart Study. Diabetes Care. 2020. Epub 2020/10/10. doi: 10.2337/dc19-1758. (PubMed ID Number: 33033069).
Hoekstra M, Chen HY, Rong J, Dufresne L, Yao J, Guo X, Tsai MY, Tsimikas S, Post WS, Vasan RS, Rotter JI, Larson MG, Thanassoulis G, Engert JC. Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels. Arterioscler Thromb Vasc Biol. 2020:Atvbaha120314965. Epub 2020/10/30. doi: 10.1161/atvbaha.120.314965. (PubMed ID Number: 33115273).
Khera R, Pandey A, Ayers CR, Carnethon MR, Greenland P, Ndumele CE, Nambi V, Seliger SL, Chaves PHM, Safford MM, Cushman M, Xanthakis V, Ramachandran VS, Mentz RJ, Correa A, Lloyd-Jones DM, Berry JD, de Lemos JA, Neeland IJ. Performance of the Pooled Cohort Equations to Estimate Atherosclerotic Cardiovascular Disease Risk by Body Mass Index. JAMA Netw Open. 2020;3(10):e2023242. Epub 2020/10/30. doi: 10.1001/jamanetworkopen.2020.23242. (PubMed ID Number: 33119108).
Long MT, Zhang X, Xu H, Liu CT, Corey KE, Chung RT, Loomba R, Benjamin EJ. Hepatic fibrosis associates with multiple cardiometabolic disease risk factors: The Framingham Heart Study. Hepatology. 2020. Epub 2020/10/31. doi: 10.1002/hep.31608. (PubMed ID Number: 33125745).
Murthy VL, Reis JP, Pico AR, Kitchen R, Lima JAC, Lloyd-Jones D, Allen NB, Carnethon M, Lewis GD, Nayor M, Vasan RS, Freedman JE, Clish CB, Shah RV. Comprehensive Metabolic Phenotyping Refines Cardiovascular Risk in Young Adults. Circulation. 2020. Epub 2020/10/20. doi: 10.1161/circulationaha.120.047689. (PubMed ID Number: 33073606).
Sanders JL, Putman RK, Dupuis J, Xu H, Murabito JM, Araki T, Nishino M, Benjamin EJ, Levy DL, Vasan RS, Washko GR, Curtis JL, Freeman CM, Bowler R, Hatabu H, O’Connor GT, Hunninghake GM. The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality. Am J Respir Crit Care Med. 2020. Epub 2020/10/21. doi: 10.1164/rccm.202007-2993OC. (PubMed ID Number: 33080140).
Sarnowski C, Huan T, Jain D, Liu C, Yao C, Joehanes R, Levy D, Dupuis J. JEM: A joint test to estimate the effect of multiple genetic variants on DNA methylation. Genet Epidemiol. 2020. Epub 2020/10/11. doi: 10.1002/gepi.22369. (PubMed ID Number: 33038041).
Stefanidou M, Beiser AS, Himali JJ, Peng TJ, Devinsky O, Seshadri S, Friedman D. The bi-directional association between epilepsy and dementia. The Framingham Heart Study. Neurology. 2020. Epub 2020/10/25. doi: 10.1212/wnl.0000000000011077. (PubMed ID Number: 33097599).
Tun B, Ehrbar R, Short M, Cheng S, Vasan RS, Xanthakis V. Association of Exhaled Carbon Monoxide With Ideal Cardiovascular Health, Circulating Biomarkers, and Incidence of Heart Failure in the Framingham Offspring Study. J Am Heart Assoc. 2020:e016762. Epub 2020/10/27. doi: 10.1161/jaha.120.016762. (PubMed ID Number: 33100134).
Williams PT. Quantile-dependent expressivity of plasma adiponectin concentrations may explain its sex-specific heritability, gene-environment interactions, and genotype-specific response to postprandial lipemia. PeerJ. 2020;8:e10099. Epub 2020/10/23. doi: 10.7717/peerj.10099. (PubMed ID Number: 33088620; PMCID: PMC7568478).
Yang T, Wei P, Pan W. Integrative Analysis Of Multi-Omics Data For Discovering Low-Frequency Variants Associated With Low-Density Lipoprotein Cholesterol Levels. Bioinformatics. 2020. Epub 2020/10/19. doi: 10.1093/bioinformatics/btaa898. (PubMed ID Number: 33070182).
Zhao X, Qiao D, Yang C, Kasela S, Kim W, Ma Y, Shrine N, Batini C, Sofer T, Taliun SAG, Sakornsakolpat P, Balte PP, Prokopenko D, Yu B, Lange LA, Dupuis J, Cade BE, Lee J, Gharib SA, Daya M, Laurie CA, Ruczinski I, Cupples LA, Loehr LR, Bartz TM, Morrison AC, Psaty BM, Vasan RS, Wilson JG, Taylor KD, Durda P, Johnson WC, Cornell E, Guo X, Liu Y, Tracy RP, Ardlie KG, Aguet F, VanDenBerg DJ, Papanicolaou GJ, Rotter JI, Barnes KC, Jain D, Nickerson DA, Muzny DM, Metcalf GA, Doddapaneni H, Dugan-Perez S, Gupta N, Gabriel S, Rich SS, O’Connor GT, Redline S, Reed RM, Laurie CC, Daviglus ML, Preudhomme LK, Burkart KM, Kaplan RC, Wain LV, Tobin MD, London SJ, Lappalainen T, Oelsner EC, Abecasis GR, Silverman EK, Barr RG, Cho MH, Manichaikul A. Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants. Nat Commun. 2020;11(1):5182. Epub 2020/10/16. doi: 10.1038/s41467-020-18334-7. (PubMed ID Number: 33057025).
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November
Benschop L, Brouwers L, Zoet GA, Meun C, Boersma E, Budde RPJ, Fauser B, de Groot CMJ, van der Schouw YT, Maas A, Velthuis BK, Linstra KM, Kavousi M, Duvekot JJ, Franx A, Steegers E, van Rijn BB, Roeters van Lennep JE. Early Onset of Coronary Artery Calcification in Women With Previous Preeclampsia. Circ Cardiovasc Imaging. 2020;13(11):e010340. Epub 2020/11/17. doi: 10.1161/circimaging.119.010340. (PubMed ID Number: 33190533).
Choudhuri A, Trompouki E, Abraham BJ, Colli LM, Kock KH, Mallard W, Yang ML, Vinjamur DS, Ghamari A, Sporrij A, Hoi K, Hummel B, Boatman S, Chan V, Tseng S, Nandakumar SK, Yang S, Lichtig A, Superdock M, Grimes SN, Bowman TV, Zhou Y, Takahashi S, Joehanes R, Cantor AB, Bauer DE, Ganesh SK, Rinn J, Albert PS, Bulyk ML, Chanock SJ, Young RA, Zon LI. Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits. Nat Genet. 2020;52(12):1333-45. Epub 2020/11/25. doi: 10.1038/s41588-020-00738-2. (PubMed ID Number: 33230299; PMCID: PMC7876911).
Georgakis MK, de Lemos JA, Ayers C, Wang B, Björkbacka H, Pana TA, Thorand B, Sun C, Fani L, Malik R, Dupuis J, Engström G, Orho-Melander M, Melander O, Boekholdt SM, Zierer A, Elhadad MA, Koenig W, Herder C, Hoogeveen RC, Kavousi M, Ballantyne CM, Peters A, Myint PK, Nilsson J, Benjamin EJ, Dichgans M. Association of Circulating Monocyte Chemoattractant Protein-1 Levels With Cardiovascular Mortality: A Meta-analysis of Population-Based Studies. JAMA Cardiol. 2020. Epub 2020/11/05. doi: 10.1001/JAMAcardio.2020.5392. (PubMed ID Number: 33146689).
Grenn FP, Kim JJ, Makarious MB, Iwaki H, Illarionova A, Brolin K, Kluss JH, Schumacher-Schuh AF, Leonard H, Faghri F, Billingsley K, Krohn L, Hall A, Diez-Fairen M, Periñán MT, Foo JN, Sandor C, Webber C, Fiske BK, Gibbs JR, Nalls MA, Singleton AB, Bandres-Ciga S, Reed X, Blauwendraat C. The Parkinson’s Disease Genome-Wide Association Study Locus Browser. Mov Disord. 2020;35(11):2056-67. Epub 2020/08/31. doi: 10.1002/mds.28197. (PubMed ID Number: 32864809; PMCID: PMC7754106).
Hahn J, Fu YP, Brown MR, Bis JC, de Vries PS, Feitosa MF, Yanek LR, Weiss S, Giulianini F, Smith AV, Guo X, Bartz TM, Becker DM, Becker LC, Boerwinkle E, Brody JA, Chen YI, Franco OH, Grove M, Harris TB, Hofman A, Hwang SJ, Kral BG, Launer LJ, Markus MRP, Rice KM, Rich SS, Ridker PM, Rivadeneira F, Rotter JI, Sotoodehnia N, Taylor KD, Uitterlinden AG, Völker U, Völzke H, Yao J, Chasman DI, Dörr M, Gudnason V, Mathias RA, Post W, Psaty BM, Dehghan A, O’Donnell CJ, Morrison AC. Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. PLoS One. 2020;15(11):e0230035. Epub 2020/11/14. doi: 10.1371/journal.pone.0230035. (PubMed ID Number: 33186364; PMCID: PMC7665790).
Janjua SA, Massaro JM, Chuang ML, D’Agostino RB, Hoffmann U, O’Donnell CJ. Thresholds for Abdominal Aortic Calcium That Predict Cardiovascular Disease Events in the Framingham Heart Study. JACC Cardiovasc Imaging. 2021;14(3):695-7. Epub 2020/11/23. doi: 10.1016/j.jcmg.2020.09.019. (PubMed ID Number: 33221220).
Kulminski AM, Philipp I, Loika Y, He L, Culminskaya I. Haplotype architecture of the Alzheimer’s risk in the APOE region via co-skewness. Alzheimers Dement (Amst). 2020;12(1):e12129. Epub 2020/11/19. doi: 10.1002/dad2.12129. (PubMed ID Number: 33204816; PMCID: PMC7656174).
Kwan AC, Salto G, Demosthenes E, Lehman BT, Osypiuk E, Stantchev P, Vasan RS, Cheng S. High-throughput digitization of analog human echocardiography data. MethodsX. 2020;7:101159. Epub 2021/03/06. doi: 10.1016/j.mex.2020.101159. (PubMed ID Number: 33665148; PMCID: PMC7897705).
Mokhtarzadeh H, Anderson DE, Allaire BT, Bouxsein ML. Patterns of Load-to-Strength Ratios Along the Spine in a Population-Based Cohort to Evaluate the Contribution of Spinal Loading to Vertebral Fractures. J Bone Miner Res. 2020. Epub 2020/12/01. doi: 10.1002/jbmr.4222. (PubMed ID Number: 33253414).
Muchira JM, Gona PN, Mogos MF, Stuart-Shor E, Leveille SG, Piano MR, Hayman LL. Parental cardiovascular health predicts time to onset of cardiovascular disease in offspring. Eur J Prev Cardiol. 2020. Epub 2021/02/25. doi: 10.1093/eurjpc/zwaa072. (PubMed ID Number: 33624039).
Philibert R, Long JD, Mills JA, Beach SRH, Gibbons FX, Gerrard M, Simons R, Pinho PB, Ingle D, Dawes K, Dogan T, Dogan M. A simple, rapid, interpretable, actionable and implementable digital PCR based mortality index. Epigenetics. 2020:1-15. Epub 2020/11/04. doi: 10.1080/15592294.2020.1841874. (PubMed ID Number: 33138668).
Shi B, Wei P, Huang X. Functional principal component based landmark analysis for the effects of longitudinal cholesterol profiles on the risk of coronary heart disease. Stat Med. 2021;40(3):650-67. Epub 2020/11/07. doi: 10.1002/sim.8794. (PubMed ID Number: 33155338).
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B, Yao C, Kraja AT, Cartwright JH, Hellwege JN, Giri A, Tragante V, Thorleifsson G, Liu DJ, Prins BP, Stewart ID, Cabrera CP, Eales JM, Akbarov A, Auer PL, Bielak LF, Bis JC, Braithwaite VS, Brody JA, Daw EW, Warren HR, Drenos F, Nielsen SF, Faul JD, Fauman EB, Fava C, Ferreira T, Foley CN, Franceschini N, Gao H, Giannakopoulou O, Giulianini F, Gudbjartsson DF, Guo X, Harris SE, Havulinna AS, Helgadottir A, Huffman JE, Hwang SJ, Kanoni S, Kontto J, Larson MG, Li-Gao R, Lindström J, Lotta LA, Lu Y, Luan J, Mahajan A, Malerba G, Masca NGD, Mei H, Menni C, Mook-Kanamori DO, Mosen-Ansorena D, Müller-Nurasyid M, Paré G, Paul DS, Perola M, Poveda A, Rauramaa R, Richard M, Richardson TG, Sepúlveda N, Sim X, Smith AV, Smith JA, Staley JR, Stanáková A, Sulem P, Thériault S, Thorsteinsdottir U, Trompet S, Varga TV, Velez Edwards DR, Veronesi G, Weiss S, Willems SM, Yao J, Young R, Yu B, Zhang W, Zhao JH, Zhao W, Zhao W, Evangelou E, Aeschbacher S, Asllanaj E, Blankenberg S, Bonnycastle LL, Bork-Jensen J, Brandslund I, Braund PS, Burgess S, Cho K, Christensen C, Connell J, Mutsert R, Dominiczak AF, Dörr M, Eiriksdottir G, Farmaki AE, Gaziano JM, Grarup N, Grove ML, Hallmans G, Hansen T, Have CT, Heiss G, Jørgensen ME, Jousilahti P, Kajantie E, Kamat M, Käräjämäki A, Karpe F, Koistinen HA, Kovesdy CP, Kuulasmaa K, Laatikainen T, Lannfelt L, Lee IT, Lee WJ, Linneberg A, Martin LW, Moitry M, Nadkarni G, Neville MJ, Palmer CNA, Papanicolaou GJ, Pedersen O, Peters J, Poulter N, Rasheed A, Rasmussen KL, Rayner NW, Mägi R, Renström F, Rettig R, Rossouw J, Schreiner PJ, Sever PS, Sigurdsson EL, Skaaby T, Sun YV, Sundstrom J, Thorgeirsson G, Esko T, Trabetti E, Tsao PS, Tuomi T, Turner ST, Tzoulaki I, Vaartjes I, Vergnaud AC, Willer CJ, Wilson PWF, Witte DR, Yonova-Doing E, Zhang H, Aliya N, Almgren P, Amouyel P, Asselbergs FW, Barnes MR, Blakemore AI, Boehnke M, Bots ML, Bottinger EP, Buring JE, Chambers JC, Chen YI, Chowdhury R, Conen D, Correa A, Davey Smith G, Boer RA, Deary IJ, Dedoussis G, Deloukas P, Di Angelantonio E, Elliott P, Felix SB, Ferrières J, Ford I, Fornage M, Franks PW, Franks S, Frossard P, Gambaro G, Gaunt TR, Groop L, Gudnason V, Harris TB, Hayward C, Hennig BJ, Herzig KH, Ingelsson E, Tuomilehto J, Järvelin MR, Jukema JW, Kardia SLR, Kee F, Kooner JS, Kooperberg C, Launer LJ, Lind L, Loos RJF, Majumder AAS, Laakso M, McCarthy MI, Melander O, Mohlke KL, Murray AD, Nordestgaard BG, Orho-Melander M, Packard CJ, Padmanabhan S, Palmas W, Polasek O, Porteous DJ, Prentice AM, Province MA, Relton CL, Rice K, Ridker PM, Rolandsson O, Rosendaal FR, Rotter JI, Rudan I, Salomaa V, Samani NJ, Sattar N, Sheu WH, Smith BH, Soranzo N, Spector TD, Starr JM, Sebert S, Taylor KD, Lakka TA, Timpson NJ, Tobin MD, van der Harst P, van der Meer P, Ramachandran VS, Verweij N, Virtamo J, Völker U, Weir DR, Zeggini E, Charchar FJ, Wareham NJ, Langenberg C, Tomaszewski M, Butterworth AS, Caulfield MJ, Danesh J, Edwards TL, Holm H, Hung AM, Lindgren CM, Liu C, Manning AK, Morris AP, Morrison AC, O’Donnell CJ, Psaty BM, Saleheen D, Stefansson K, Boerwinkle E, Chasman DI, Levy D, Newton-Cheh C, Munroe PB, Howson JMM. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nat Genet. 2020;52(12):1314-32. Epub 2020/11/25. doi: 10.1038/s41588-020-00713-x. (PubMed ID Number: 33230300).
Velagaleti RS, Vasan RS. Restarting Human Participant Research at Community-based Observational Studies during the COVID-19 Pandemic. J Am Heart Assoc. 2020;9(21):e018832. Epub 2020/09/30. doi: 10.1161/jaha.120.018832. (PubMed ID Number: 32990138; PMCID: PMC7763408).
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December
Baril AA, Beiser AS, Mysliwiec V, Sanchez E, DeCarli CS, Redline S, Gottlieb DJ, Maillard P, Romero JR, Satizabal CL, Zucker JM, Seshadri S, Pase MP, Himali JJ. Slow-wave Sleep and MRI Markers of Brain Aging in a Community-based Sample. Neurology. 2020. Epub 2020/12/29. doi: 10.1212/wnl.0000000000011377. (PubMed ID Number: 33361258).
Cherry JD, Meng G, Daley S, Xia W, Svirsky S, Alvarez VE, Nicks R, Pothast M, Kelley H, Huber B, Tripodis Y, Alosco ML, Mez J, McKee AC, Stein TD. CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy. J Neuroinflammation. 2020;17(1):370. Epub 2020/12/07. doi: 10.1186/s12974-020-02036-4. (PubMed ID Number: 33278887; PMCID: PMC7718711).
Corlin L, Liu C, Lin H, Leone D, Yang Q, Ngo D, Levy D, Cupples LA, Gerszten RE, Larson MG, Vasan RS. Proteomic Signatures of Lifestyle Risk Factors for Cardiovascular Disease: A Cross-Sectional Analysis of the Plasma Proteome in the Framingham Heart Study. J Am Heart Assoc. 2021;10(1):e018020. Epub 2020/12/30. doi: 10.1161/jaha.120.018020. (PubMed ID Number: 33372532).
Ezzaty Mirhashemi M, Shah RV, Kitchen RR, Rong J, Spahillari A, Pico AR, Vitseva O, Levy D, Demarco D, Shah S, Iafrati MD, Larson MG, Tanriverdi K, Freedman JE. The Dynamic Platelet Transcriptome in Obesity and Weight Loss. Arterioscler Thromb Vasc Biol. 2020:Atvbaha120315186. Epub 2020/12/11. doi: 10.1161/atvbaha.120.315186. (PubMed ID Number: 33297754).
Goumidi L, Thibord F, Wiggins KL, Li-Gao R, Brown MR, van Hylckama Vlieg A, Souto JC, Soria JM, Ibrahim-Kosta M, Saut N, Daian-Bacq D, Olaso R, Amouyel P, Debette S, Boland A, Bailly P, Morrison A, Mook-Kanamori DO, Deleuze JF, Johnson AD, de Vries PS, Sabater-Lleal M, Chiaroni J, Smith NL, Rosendaal FR, Chasman DI, Tregouet D, Morange PE. Association of ABO haplotypes with the risk of venous thrombosis: impact on disease risks estimation. Blood. 2020. Epub 2021/01/30. doi: 10.1182/blood.2020008997. (PubMed ID Number: 33512453).
Knol MJ, Lu D, Traylor M, Adams HHH, Romero JRJ, Smith AV, Fornage M, Hofer E, Liu J, Hostettler IC, Luciano M, Trompet S, Giese AK, Hilal S, van den Akker EB, Vojinovic D, Li S, Sigurdsson S, van der Lee SJ, Jack CR, Jr., Wilson D, Yilmaz P, Satizabal CL, Liewald DCM, van der Grond J, Chen C, Saba Y, van der Lugt A, Bastin ME, Windham BG, Cheng CY, Pirpamer L, Kantarci K, Himali JJ, Yang Q, Morris Z, Beiser AS, Tozer DJ, Vernooij MW, Amin N, Beekman M, Koh JY, Stott DJ, Houlden H, Schmidt R, Gottesman RF, MacKinnon AD, DeCarli C, Gudnason V, Deary IJ, van Duijn CM, Slagboom PE, Wong TY, Rost NS, Jukema JW, Mosley TH, Werring DJ, Schmidt H, Wardlaw JM, Ikram MA, Seshadri S, Launer LJ, Markus HS. Association of common genetic variants with brain microbleeds: A genome-wide association study. Neurology. 2020;95(24):e3331-e43. Epub 2020/09/12. doi: 10.1212/wnl.0000000000010852. (PubMed ID Number: 32913026; PMCID: PMC7836652).
Nielsen JB, Rom O, Surakka I, Graham SE, Zhou W, Roychowdhury T, Fritsche LG, Gagliano Taliun SA, Sidore C, Liu Y, Gabrielsen ME, Skogholt AH, Wolford B, Overton W, Zhao Y, Chen J, Zhang H, Hornsby WE, Acheampong A, Grooms A, Schaefer A, Zajac GJM, Villacorta L, Zhang J, Brumpton B, Løset M, Rai V, Lundegaard PR, Olesen MS, Taylor KD, Palmer ND, Chen YD, Choi SH, Lubitz SA, Ellinor PT, Barnes KC, Daya M, Rafaels N, Weiss ST, Lasky-Su J, Tracy RP, Vasan RS, Cupples LA, Mathias RA, Yanek LR, Becker LC, Peyser PA, Bielak LF, Smith JA, Aslibekyan S, Hidalgo BA, Arnett DK, Irvin MR, Wilson JG, Musani SK, Correa A, Rich SS, Guo X, Rotter JI, Konkle BA, Johnsen JM, Ashley-Koch AE, Telen MJ, Sheehan VA, Blangero J, Curran JE, Peralta JM, Montgomery C, Sheu WH, Chung RH, Schwander K, Nouraie SM, Gordeuk VR, Zhang Y, Kooperberg C, Reiner AP, Jackson RD, Bleecker ER, Meyers DA, Li X, Das S, Yu K, LeFaive J, Smith A, Blackwell T, Taliun D, Zollner S, Forer L, Schoenherr S, Fuchsberger C, Pandit A, Zawistowski M, Kheterpal S, Brummett CM, Natarajan P, Schlessinger D, Lee S, Kang HM, Cucca F, Holmen OL, Åsvold BO, Boehnke M, Kathiresan S, Abecasis GR, Chen YE, Willer CJ, Hveem K. Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease. Nat Commun. 2020;11(1):6417. Epub 2020/12/20. doi: 10.1038/s41467-020-20086-3. (PubMed ID Number: 33339817; PMCID: PMC7749177).
Orkaby AR, Kornej J, Lubitz SA, McManus DD, Travison TG, Sherer JA, Trinquart L, Murabito JM, Benjamin EJ, Preis SR. Association Between Frailty and Atrial Fibrillation in Older Adults: The Framingham Heart Study Offspring Cohort. J Am Heart Assoc. 2021;10(1):e018557. Epub 2020/12/30. doi: 10.1161/jaha.120.018557. (PubMed ID Number: 33372538).
Sargurupremraj M, Suzuki H, Jian X, Sarnowski C, Evans TE, Bis JC, Eiriksdottir G, Sakaue S, Terzikhan N, Habes M, Zhao W, Armstrong NJ, Hofer E, Yanek LR, Hagenaars SP, Kumar RB, van den Akker EB, McWhirter RE, Trompet S, Mishra A, Saba Y, Satizabal CL, Beaudet G, Petit L, Tsuchida A, Zago L, Schilling S, Sigurdsson S, Gottesman RF, Lewis CE, Aggarwal NT, Lopez OL, Smith JA, Valdés Hernández MC, van der Grond J, Wright MJ, Knol MJ, Dörr M, Thomson RJ, Bordes C, Le Grand Q, Duperron MG, Smith AV, Knopman DS, Schreiner PJ, Evans DA, Rotter JI, Beiser AS, Maniega SM, Beekman M, Trollor J, Stott DJ, Vernooij MW, Wittfeld K, Niessen WJ, Soumaré A, Boerwinkle E, Sidney S, Turner ST, Davies G, Thalamuthu A, Völker U, van Buchem MA, Bryan RN, Dupuis J, Bastin ME, Ames D, Teumer A, Amouyel P, Kwok JB, Bülow R, Deary IJ, Schofield PR, Brodaty H, Jiang J, Tabara Y, Setoh K, Miyamoto S, Yoshida K, Nagata M, Kamatani Y, Matsuda F, Psaty BM, Bennett DA, De Jager PL, Mosley TH, Sachdev PS, Schmidt R, Warren HR, Evangelou E, Trégouët DA, Ikram MA, Wen W, DeCarli C, Srikanth VK, Jukema JW, Slagboom EP, Kardia SLR, Okada Y, Mazoyer B, Wardlaw JM, Nyquist PA, Mather KA, Grabe HJ, Schmidt H, Van Duijn CM, Gudnason V, Longstreth WT, Jr., Launer LJ, Lathrop M, Seshadri S, Tzourio C, Adams HH, Matthews PM, Fornage M, Debette S. Cerebral small vessel disease genomics and its implications across the lifespan. Nat Commun. 2020;11(1):6285. Epub 2020/12/10. doi: 10.1038/s41467-020-19111-2. (PubMed ID Number: 33293549; PMCID: PMC7722866).
Taron J, Lyass A, Mahoney TF, Ehrbar RQ, Vasan RS, D’Agostino RB, Sr., Hoffmann U, Massaro JM, Lu MT. Coronary Artery Calcium Score-Directed Primary Prevention With Statins on the Basis of the 2018 American College of Cardiology/American Heart Association/Multisociety Cholesterol Guidelines. J Am Heart Assoc. 2021;10(1):e018342. Epub 2020/12/23. doi: 10.1161/jaha.120.018342. (PubMed ID Number: 33348999).
Vojinovic D, Kalaoja M, Trompet S, Fischer K, Shipley MJ, Li S, Havulinna AS, Perola M, Salomaa V, Yang Q, Sattar N, Jousilahti P, Amin N, Satizabal CL, Taba N, Sabayan B, Vasan RS, Ikram MA, Stott DJ, Ala-Korpela M, Jukema JW, Seshadri S, Kettunen J, Kivimaki M, Esko T, van Duijn CM. Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts. Neurology. 2020. Epub 2020/12/04. doi: 10.1212/wnl.0000000000011236. (PubMed ID Number: 33268560).
von Jeinsen B, Vasan RS, McManus DD, Mitchell GF, Cheng S, Xanthakis V. Joint influences of obesity, diabetes, and hypertension on indices of ventricular remodeling: Findings from the community-based Framingham Heart Study. PLoS One. 2020;15(12):e0243199. Epub 2020/12/11. doi: 10.1371/journal.pone.0243199. (PubMed ID Number: 33301464; PMCID: PMC7728232).
Williams PT. Quantile-specific heritability of sibling leptin concentrations and its implications for gene-environment interactions. Sci Rep. 2020;10(1):22152. Epub 2020/12/19. doi: 10.1038/s41598-020-79116-1. (PubMed ID Number: 33335207; PMCID: PMC7747738).
Williams PT. Quantile-specific heritability of total cholesterol and its pharmacogenetic and nutrigenetic implications. Int J Cardiol. 2021;327:185-92. Epub 2020/12/10. doi: 10.1016/j.ijcard.2020.11.070. (PubMed ID Number: 33296721; PMCID: PMC7897293).
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