FHS Bibliography – 2024

Framingham Heart Study Bibliography – 2024

January

Darden ME, Papageorge NW. Rational self-medication. Econ Hum Biol. 2024;53:101350. Epub 20240128. doi: 10.1016/j.ehb.2024.101350. (PubMed PMID: 38335911).

De Anda-Duran I, Sunderaraman P, Searls E, Moukaled S, Jin X, Popp Z, Karjadi C, Hwang PH, Ding H, Devine S, Shih LC, Low S, Lin H, Kolachalama VB, Bazzano L, Libon DJ, Au R. Comparing Cognitive Tests and Smartphone-Based Assessment in 2 US Community-Based Cohorts. J Am Heart Assoc. 2024;13(2):e032733. Epub 20240116. doi: 10.1161/jaha.123.032733. (PubMed PMID: 38226519; PMCID: PMC10926794).

Domínguez-Barragán J, Fernández-Sanlés A, Hernáez Á, Llauradó-Pont J, Marrugat J, Robinson O, Tzoulaki I, Elosua R, Lassale C. Blood DNA methylation signature of diet quality and association with cardiometabolic traits. Eur J Prev Cardiol. 2024;31(2):191-202. doi: 10.1093/eurjpc/zwad317. (PubMed PMID: 37793095; PMCID: PMC10809172).

Guirette M, Lan J, McKeown NM, Brown MR, Chen H, de Vries PS, Kim H, Rebholz CM, Morrison AC, Bartz TM, Fretts AM, Guo X, Lemaitre RN, Liu CT, Noordam R, de Mutsert R, Rosendaal FR, Wang CA, Beilin LJ, Mori TA, Oddy WH, Pennell CE, Chai JF, Whitton C, van Dam RM, Liu J, Tai ES, Sim X, Neuhouser ML, Kooperberg C, Tinker LF, Franceschini N, Huan T, Winkler TW, Bentley AR, Gauderman WJ, Heerkens L, Tanaka T, van Rooij J, Munroe PB, Warren HR, Voortman T, Chen H, Rao DC, Levy D, Ma J. Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure. Hypertension. 2024;81(3):552-60. Epub 20240116. doi: 10.1161/hypertensionaha.123.22334. (PubMed PMID: 38226488; PMCID: PMC10922535).

Higbee DH, Lirio A, Hamilton F, Granell R, Wyss AB, London SJ, Bartz TM, Gharib SA, Cho MH, Wan E, Silverman E, Crapo JD, Lominchar JVT, Hansen T, Grarup N, Dantoft T, Kårhus L, Linneberg A, O’Connor GT, Dupuis J, Xu H, De Vries MM, Hu X, Rich SS, Barr RG, Manichaikul A, Wijnant SRA, Brusselle GG, Lahousse L, Li X, Hernández Cordero AI, Obeidat M, Sin DD, Harris SE, Redmond P, Taylor AM, Cox SR, Williams AT, Shrine N, John C, Guyatt AL, Hall IP, Davey Smith G, Tobin MD, Dodd JW. Genome-wide association study of preserved ratio impaired spirometry (PRISm). Eur Respir J. 2024;63(1). Epub 20240104. doi: 10.1183/13993003.00337-2023. (PubMed PMID: 38097206; PMCID: PMC10765494).

Kim SJ, Miller B, Hartel NG, Ramirez R, 2nd, Braniff RG, Leelaprachakul N, Huang A, Wang Y, Arpawong TE, Crimmins EM, Wang P, Sun X, Liu C, Levy D, Yen K, Petzinger GM, Graham NA, Jakowec MW, Cohen P. A naturally occurring variant of SHLP2 is a protective factor in Parkinson’s disease. Mol Psychiatry. 2024;29(2):505-17. Epub 20240103. doi: 10.1038/s41380-023-02344-0. (PubMed PMID: 38167865; PMCID: PMC11116102).

Mei H, Simino J, Li L, Jiang F, Bis JC, Davies G, Hill WD, Xia C, Gudnason V, Yang Q, Lahti J, Smith JA, Kirin M, De Jager P, Armstrong NJ, Ghanbari M, Kolcic I, Moran C, Teumer A, Sargurupremraj M, Mahmud S, Fornage M, Zhao W, Satizabal CL, Polasek O, Räikkönen K, Liewald DC, Homuth G, Callisaya M, Mather KA, Windham BG, Zemunik T, Palotie A, Pattie A, van der Auwera S, Thalamuthu A, Knopman DS, Rudan I, Starr JM, Wittfeld K, Kochan NA, Griswold ME, Vitart V, Brodaty H, Gottesman R, Cox SR, Psaty BM, Boerwinkle E, Chasman DI, Grodstein F, Sachdev PS, Srikanth V, Hayward C, Wilson JF, Eriksson JG, Kardia SLR, Grabe HJ, Bennett DA, Ikram MA, Deary IJ, van Duijn CM, Launer L, Fitzpatrick AL, Seshadri S, Bressler J, Debette S, Mosley TH, Jr. Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance. Alzheimers Res Ther. 2024;16(1):14. Epub 20240120. doi: 10.1186/s13195-023-01376-6. (PubMed PMID: 38245754; PMCID: PMC10799499).

Ogburn EL, Sofrygin O, Díaz I, van der Laan MJ. Causal Inference for Social Network Data. J Am Stat Assoc. 2024;119(545):597-611. Epub 20221212. doi: 10.1080/01621459.2022.2131557. (PubMed PMID: 38800714; PMCID: PMC11114213).

Pase MP, Himali JJ, Puerta R, Beiser AS, Gonzales MM, Satizabal CL, Yang Q, Aparicio HJ, Kojis DJ, Decarli CS, Lopez OL, Longstreth W, Gudnason V, Mosley TH, Bis JC, Fohner A, Psaty BM, Boada M, García-González P, Valero S, Marquié M, Tracy R, Launer LJ, Ruiz A, Fornage M, Seshadri S. Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia. Neurology. 2024;102(4):e208075. Epub 20240130. doi: 10.1212/wnl.0000000000208075. (PubMed PMID: 38290090; PMCID: PMC11383876).

Sunderaraman P, De Anda-Duran I, Karjadi C, Peterson J, Ding H, Devine SA, Shih LC, Popp Z, Low S, Hwang PH, Goyal K, Hathaway L, Monteverde J, Lin H, Kolachalama VB, Au R. Design and Feasibility Analysis of a Smartphone-Based Digital Cognitive Assessment Study in the Framingham Heart Study. J Am Heart Assoc. 2024;13(2):e031348. Epub 20240116. doi: 10.1161/jaha.123.031348. (PubMed PMID: 38226510; PMCID: PMC10926817).

Tejeda M, Farrell J, Zhu C, Wetzler L, Lunetta KL, Bush WS, Martin ER, Wang LS, Schellenberg GD, Pericak-Vance MA, Haines JL, Farrer LA, Sherva R. DNA from multiple viral species is associated with Alzheimer’s disease risk. Alzheimers Dement. 2024;20(1):253-65. Epub 20230814. doi: 10.1002/alz.13414. (PubMed PMID: 37578203; PMCID: PMC10840621).

Ukraintseva S, Duan H, Holmes R, Bagley O, Wu D, Yashkin A, Kulminski A, Akushevich I, Whitson H, Stallard E, Yashin A, Arbeev K. Patterns of Aging Changes in Bodyweight May Predict Alzheimer’s Disease. J Alzheimers Dis. 2024;97(1):163-70. doi: 10.3233/jad-220998. (PubMed PMID: 38108347; PMCID: PMC10789330).

Wang S, Kim S, Ryan Cho H, Chang W. Nonparametric predictive model for sparse and irregular longitudinal data. Biometrics. 2024;80(1). doi: 10.1093/biomtc/ujad023. (PubMed PMID: 38372401).

Whitman ET, Ryan CP, Abraham WC, Addae A, Corcoran DL, Elliott ML, Hogan S, Ireland D, Keenan R, Knodt AR, Melzer TR, Poulton R, Ramrakha S, Sugden K, Williams BS, Zhou J, Hariri AR, Belsky DW, Moffitt TE, Caspi A. A blood biomarker of the pace of aging is associated with brain structure: replication across three cohorts. Neurobiol Aging. 2024;136:23-33. Epub 20240124. doi: 10.1016/j.neurobiolaging.2024.01.008. (PubMed PMID: 38301452; PMCID: PMC11017787).

Ying K, Liu H, Tarkhov AE, Sadler MC, Lu AT, Moqri M, Horvath S, Kutalik Z, Shen X, Gladyshev VN. Causality-enriched epigenetic age uncouples damage and adaptation. Nat Aging. 2024;4(2):231-46. Epub 20240119. doi: 10.1038/s43587-023-00557-0. (PubMed PMID: 38243142; PMCID: PMC11070280).

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February

Ding H, Kim M, Searls E, Sunderaraman P, De Anda-Duran I, Low S, Popp Z, Hwang PH, Li Z, Goyal K, Hathaway L, Monteverde J, Rahman S, Igwe A, Kolachalama VB, Au R, Lin H. Digital neuropsychological measures by defense automated neurocognitive assessment: reference values and clinical correlates. Front Neurol. 2024;15:1340710. Epub 20240215. doi: 10.3389/fneur.2024.1340710. (PubMed PMID: 38426173; PMCID: PMC10902432).

Guan Y, Levy D. Estimation of inbreeding and kinship coefficients via latent identity-by-descent states. Bioinformatics. 2024;40(2). doi: 10.1093/bioinformatics/btae082. (PubMed PMID: 38364309; PMCID: PMC10902678).

Kim JS, Sun Y, Balte P, Cushman M, Boyle R, Tracy RP, Styer LM, Bell TD, Anderson MR, Allen NB, Schreiner PJ, Bowler RP, Schwartz DA, Lee JS, Xanthakis V, Doyle MF, Regan EA, Make BJ, Kanaya AM, Wenzel SE, Coresh J, Isasi CR, Raffield LM, Elkind MSV, Howard VJ, Ortega VE, Woodruff P, Cole SA, Henderson JM, Mantis NJ, Parker MM, Demmer RT, Oelsner EC. Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study. Nat Commun. 2024;15(1):1492. Epub 20240219. doi: 10.1038/s41467-024-45468-9. (PubMed PMID: 38374032; PMCID: PMC10876680).

Krefman AE, Stephen J, Carolan P, Sedaghat S, Mansolf M, Soumare A, Gross AL, Aiello AE, Singh-Manoux A, Ikram MA, Helmer C, Tzourio C, Satizabal C, Levine DA, Lloyd-Jones D, Briceño EM, Sorond FA, Wolters FJ, Himali J, Launer LJ, Zhao L, Haan M, Lopez OL, Debette S, Seshadri S, Judd SE, Hughes TM, Gudnason V, Scholtens D, Allen NB. Cohort Profile: Dementia Risk Prediction Project (DRPP). Int J Epidemiol. 2024;53(1). doi: 10.1093/ije/dyae012. (PubMed PMID: 38339864; PMCID: PMC10858348).

Lee J, Wang X, Liu C, Pathiravasan CH, Benjamin EJ, McManus DD, Murabito JM. Depressive symptoms are not associated with clinically important levels of digital home blood pressure in the electronic Framingham Heart Study. Cardiovasc Digit Health J. 2024;5(2):50-8. Epub 20240201. doi: 10.1016/j.cvdhj.2024.01.001. (PubMed PMID: 38765623; PMCID: PMC11096660).

Malamon JS, Farrell JJ, Xia LC, Dombroski BA, Das RG, Way J, Kuzma AB, Valladares O, Leung YY, Scanlon AJ, Lopez IAB, Brehony J, Worley KC, Zhang NR, Wang LS, Farrer LA, Schellenberg GD, Lee WP, Vardarajan BN. A comparative study of structural variant calling in WGS from Alzheimer’s disease families. Life Sci Alliance. 2024;7(5). Epub 20240228. doi: 10.26508/lsa.202302181. (PubMed PMID: 38418088; PMCID: PMC10902710).

Nguyen AQ, Rodriguez C, Kumar R, Gupta S, Anderson DE, Saifi C. Biomechanical analysis of complications following T10-Pelvis spinal fusion: A population based computational study. J Biomech. 2024;165:111969. Epub 20240216. doi: 10.1016/j.jbiomech.2024.111969. (PubMed PMID: 38394952).

Panitch R, Sahelijo N, Hu J, Nho K, Bennett DA, Lunetta KL, Au R, Stein TD, Farrer LA, Jun GR. APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response. Transl Psychiatry. 2024;14(1):129. Epub 20240229. doi: 10.1038/s41398-024-02834-x. (PubMed PMID: 38424036; PMCID: PMC10904829).

Shah RV, Zhong J, Massier L, Tanriverdi K, Hwang SJ, Haessler J, Nayor M, Zhao S, Perry AS, Wilkins JT, Shadyab AH, Manson JE, Martin L, Levy D, Kooperberg C, Freedman JE, Rydén M, Murthy VL. Targeted Proteomics Reveals Functional Targets for Early Diabetes Susceptibility in Young Adults. Circ Genom Precis Med. 2024;17(1):e004192. Epub 20240207. doi: 10.1161/circgen.123.004192. (PubMed PMID: 38323454; PMCID: PMC10940209).

Smith ML, Gelaye B, Tsai AC, Gradus JL. Mediation of the association between depression and coronary heart disease by metabolic syndrome components. Ann Epidemiol. 2024;92:1-7. Epub 20240209. doi: 10.1016/j.annepidem.2024.02.003. (PubMed PMID: 38341050).

Thomas A, Ryan CP, Caspi A, Liu Z, Moffitt TE, Sugden K, Zhou J, Belsky DW, Gu Y. Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study. Ann Neurol. 2024;95(6):1069-79. Epub 20240226. doi: 10.1002/ana.26900. (PubMed PMID: 38407506; PMCID: PMC11102315).

van den Ende MWJ, van der Maas HLJ, Epskamp S, Lees MH. Alcohol consumption as a socially contagious phenomenon in the Framingham Heart Study social network. Sci Rep. 2024;14(1):4499. Epub 20240224. doi: 10.1038/s41598-024-54155-0. (PubMed PMID: 38402289; PMCID: PMC11052543).

Young CB, Smith V, Karjadi C, Grogan SM, Ang TFA, Insel PS, Henderson VW, Sumner M, Poston KL, Au R, Mormino EC. Speech patterns during memory recall relates to early tau burden across adulthood. Alzheimers Dement. 2024;20(4):2552-63. Epub 20240213. doi: 10.1002/alz.13731. (PubMed PMID: 38348772; PMCID: PMC11032578).

Zhou X, Mott MM, Yiannakou I, Bradlee ML, Singer MR, Moore LL. Eggs and a Fiber-Rich Diet Are Beneficially Associated with Lipid Levels in Framingham Offspring Study Adults. Curr Dev Nutr. 2024;8(3):102062. Epub 20240222. doi: 10.1016/j.cdnut.2023.102062. (PubMed PMID: 38500805; PMCID: PMC10945122).

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March

Chan MV, Chen MH, Thibord F, Nkambule BB, Lachapelle AR, Grech J, Schneider ZE, Wallace de Melendez C, Huffman JE, Hayman MA, Allan HE, Armstrong PC, Warner TD, Johnson AD. Factors that modulate platelet reactivity as measured by 5 assay platforms in 3429 individuals. Res Pract Thromb Haemost. 2024;8(3):102406. Epub 20240412. doi: 10.1016/j.rpth.2024.102406. (PubMed PMID: 38813256; PMCID: PMC11135030).

Ding H, Liu C, Li Y, Ang TFA, Devine S, Liu Y, Au R, Doraiswamy PM. Sex-specific blood biomarkers linked to memory changes in middle-aged adults: The Framingham Heart Study. Alzheimers Dement (Amst). 2024;16(1):e12569. Epub 20240327. doi: 10.1002/dad2.12569. (PubMed PMID: 38545543; PMCID: PMC10966919).

Ding H, Wang B, Hamel AP, Karjadi C, Ang TFA, Au R, Lin H. Exploring cognitive progression subtypes in the Framingham Heart Study. Alzheimers Dement (Amst). 2024;16(1):e12574. Epub 20240321. doi: 10.1002/dad2.12574. (PubMed PMID: 38515438; PMCID: PMC10955221).

Graf GHJ, Aiello AE, Caspi A, Kothari M, Liu H, Moffitt TE, Muennig PA, Ryan CP, Sugden K, Belsky DW. Educational Mobility, Pace of Aging, and Lifespan Among Participants in the Framingham Heart Study. JAMA Netw Open. 2024;7(3):e240655. Epub 20240304. doi: 10.1001/jamanetworkopen.2024.0655. (PubMed PMID: 38427354; PMCID: PMC10907927).

Katsumata Y, Fardo DW, Shade LMP, Wu X, Karanth SD, Hohman TJ, Schneider JA, Bennett DA, Farfel JM, Gauthreaux K, Mock C, Kukull WA, Abner EL, Nelson PT. Genetic associations with dementia-related proteinopathy: Application of item response theory. Alzheimers Dement. 2024;20(4):2906-21. Epub 20240309. doi: 10.1002/alz.13741. (PubMed PMID: 38460116; PMCID: PMC11032554).

Walsh DJ, Bernard DJ, Fiddler JL, Pangilinan F, Esposito M, Harold D, Field MS, Parle-McDermott A, Brody LC. Vitamin B12 status and folic acid supplementation influence mitochondrial heteroplasmy levels in mice. PNAS Nexus. 2024;3(4):pgae116. Epub 20240315. doi: 10.1093/pnasnexus/pgae116. (PubMed PMID: 38560530; PMCID: PMC10978065).

Weinstein G, Kojis DJ, Ghosh S, Beiser AS, Seshadri S. Association of Neurotrophic Factors at Midlife With In Vivo Measures of β-Amyloid and Tau Burden 15 Years Later in Dementia-Free Adults. Neurology. 2024;102(7):e209198. Epub 20240312. doi: 10.1212/wnl.0000000000209198. (PubMed PMID: 38471064; PMCID: PMC11033983).

Zhang J, Moll M, Hobbs BD, Bakke P, Regan EA, Xu H, Dupuis J, Chiles JW, 3rd, McDonald MN, Divo MJ, Silverman EK, Celli BR, O’Connor GT, Cho MH. Genetically Predicted Body Mass Index and Mortality in COPD. Am J Respir Crit Care Med. 2024. Epub 20240312. doi: 10.1164/rccm.202308-1384OC. (PubMed PMID: 38471013).

Zhang Y, Dron JS, Bellows BK, Khera AV, Liu J, Balte PP, Oelsner EC, Amr SS, Lebo MS, Nagy A, Peloso GM, Natarajan P, Rotter JI, Willer C, Boerwinkle E, Ballantyne CM, Lutsey PL, Fornage M, Lloyd-Jones DM, Hou L, Psaty BM, Bis JC, Floyd JS, Vasan RS, Heard-Costa NL, Carson AP, Hall ME, Rich SS, Guo X, Kazi DS, de Ferranti SD, Moran AE. Familial Hypercholesterolemia Variant and Cardiovascular Risk in Individuals With Elevated Cholesterol. JAMA Cardiol. 2024;9(3):263-71. doi: 10.1001/jamacardio.2023.5366. (PubMed PMID: 38294787; PMCID: PMC10831623).

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April

Al Rifai M, Al-Mallah MH, Blaha MJ, Patel J, McEvoy JW, Nasir K, Shahid I, Patel KV, Sharma G, Marrugat J, Tizon-Marcos H, Erbel R, Stang A, Jöckel KH, Lehmann N, Schramm S, Schmidt B, Blumenthal RS, Virani SS, Nambi V, Cainzos-Achirica M. Epidemiology and Prognostic Implications of Coronary Artery Calcium in Asymptomatic Individuals With Prediabetes: A Multicohort Study. Diabetes Care. 2024;47(4):698-706. doi: 10.2337/dc23-1864. (PubMed PMID: 38329795).

Barton BA, Kronsberg SS, Hariri E, Vasan RS, Rade GA, Xanthakis V, Kickler TS, Rade JJ. Adjustment for Renal Function Improves the Prognostic Performance of Urinary Thromboxane Metabolites. Clin Chem. 2024;70(4):660-8. doi: 10.1093/clinchem/hvae015. (PubMed PMID: 38416712).

Duncan MS, Diaz-Zabala H, Jaworski J, Tindle HA, Greevy RA, Lipworth L, Hung RJ, Freiberg MS, Aldrich MC. Interaction between Continuous Pack-Years Smoked and Polygenic Risk Score on Lung Cancer Risk: Prospective Results from the Framingham Heart Study. Cancer Epidemiol Biomarkers Prev. 2024;33(4):500-8. doi: 10.1158/1055-9965.Epi-23-0571. (PubMed PMID: 38227004; PMCID: PMC10988206).

Kelly DM, Pinheiro AA, Koini M, Anderson CD, Aparicio H, Hofer E, Kern D, Blacker D, DeCarli C, Hwang SJ, Viswanathan A, Gonzales MM, Beiser AS, Seshadri S, Schmidt R, Demissie S, Romero JR. Impaired Kidney Function, Cerebral Small Vessel Disease and Cognitive Disorders: The Framingham Heart Study. Nephrol Dial Transplant. 2024. Epub 20240402. doi: 10.1093/ndt/gfae079. (PubMed PMID: 38565317).

Li C, Stražar M, Mohamed AMT, Pacheco JA, Walker RL, Lebar T, Zhao S, Lockart J, Dame A, Thurimella K, Jeanfavre S, Brown EM, Ang QY, Berdy B, Sergio D, Invernizzi R, Tinoco A, Pishchany G, Vasan RS, Balskus E, Huttenhower C, Vlamakis H, Clish C, Shaw SY, Plichta DR, Xavier RJ. Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria. Cell. 2024;187(8):1834-52.e19. Epub 20240402. doi: 10.1016/j.cell.2024.03.014. (PubMed PMID: 38569543; PMCID: PMC11071153).

Lundin JI, Peters U, Hu Y, Ammous F, Avery CL, Benjamin EJ, Bis JC, Brody JA, Carlson C, Cushman M, Gignoux C, Guo X, Haessler J, Haiman C, Joehanes R, Kasela S, Kenny E, Lapalainien T, Levy D, Liu C, Liu Y, Loos RJF, Lu A, Matise T, North KE, Park SL, Ratliff SM, Reiner A, Rich SS, Rotter JI, Smith JA, Sotoodehnia N, Tracy R, Van den Berg D, Xu H, Ye T, Zhao W, Raffield LM, Kooperberg C. Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations. Epigenetics. 2024;19(1):2333668. Epub 20240403. doi: 10.1080/15592294.2024.2333668. (PubMed PMID: 38571307; PMCID: PMC10996836).

Lyu C, Joehanes R, Huan T, Levy D, Li Y, Wang M, Liu X, Liu C, Ma J. Enhancing selection of alcohol consumption-associated genes by random forest. Br J Nutr. 2024;131(12):2058-67. Epub 20240412. doi: 10.1017/s0007114524000795. (PubMed PMID: 38606596; PMCID: PMC11216877).

Perry AS, Zhang K, Murthy VL, Choi B, Zhao S, Gajjar P, Colangelo LA, Hou L, Rice MB, Carr JJ, Carson AP, Nigra AE, Vasan RS, Gerszten RE, Khan SS, Kalhan R, Nayor M, Shah RV. Proteomics, Human Environmental Exposure, and Cardiometabolic Risk. Circ Res. 2024;135(1):138-54. Epub 20240425. doi: 10.1161/circresaha.124.324559. (PubMed PMID: 38662804; PMCID: PMC11189739).

Tang J, Xu H, Xin Z, Mei Q, Gao M, Yang T, Zhang X, Levy D, Liu CT. Identifying BMI-associated genes via a genome-wide multi-omics integrative approach using summary data. Hum Mol Genet. 2024;33(8):733-8. doi: 10.1093/hmg/ddad212. (PubMed PMID: 38215789; PMCID: PMC11000658).

Thompson LI, Cummings M, Emrani S, Libon DJ, Ang A, Karjadi C, Au R, Liu C. Digital Clock Drawing as an Alzheimer’s Disease Susceptibility Biomarker: Associations with Genetic Risk Score and APOE in Older Adults. J Prev Alzheimers Dis. 2024;11(1):79-87. doi: 10.14283/jpad.2023.48. (PubMed PMID: 38230720; PMCID: PMC10794851).

Wang X, Zhang Y, Pathiravasan CH, Ukonu NC, Rong J, Benjamin EJ, McManus DD, Larson MG, Vasan RS, Hamburg NM, Murabito JM, Liu C, Mitchell GF. Association of Arterial Stiffness With Mid- to Long-Term Home Blood Pressure Variability in the Electronic Framingham Heart Study: Cohort Study. JMIR Cardio. 2024;8:e54801. Epub 20240408. doi: 10.2196/54801. (PubMed PMID: 38587880; PMCID: PMC11036191).

Wang Y, Huang J, Ang TFA, Zhu Y, Tao Q, Mez J, Alosco M, Denis GV, Belkina A, Gurnani A, Ross M, Gong B, Han J, Lunetta KL, Stein TD, Au R, Farrer LA, Zhang X, Qiu WQ. The association between circulating CD34+CD133+ endothelial progenitor cells and reduced risk of Alzheimer’s disease in the Framingham Heart Study. Explor Med. 2024;5(2):193-214. Epub 20240412. doi: 10.37349/emed.2024.00216. (PubMed PMID: 38854406; PMCID: PMC11160969).

Wong ND, Fan W, Hu X, Ballantyne C, Hoodgeveen RC, Tsai MY, Browne A, Budoff MJ. Lipoprotein(a) and Long-Term Cardiovascular Risk in a Multi-Ethnic Pooled Prospective Cohort. J Am Coll Cardiol. 2024;83(16):1511-25. doi: 10.1016/j.jacc.2024.02.031. (PubMed PMID: 38631771).

Xin Z, Xu H, Zhang X, Samelson EJ, Kiel DP, Liu CT. Association of bone fracture with 30-year body mass index (BMI) trajectories: findings from the Framingham Heart Study: Bone fracture and 30-year BMI trajectories. Osteoporos Int. 2024;35(7):1205-12. Epub 20240408. doi: 10.1007/s00198-024-07068-7. (PubMed PMID: 38587675).

Zhu C, Tong T, Farrell JJ, Martin ER, Bush WS, Pericak-Vance MA, Wang LS, Schellenberg GD, Haines JL, Lunetta KL, Farrer LA, Zhang X. MitoH3: Mitochondrial Haplogroup and Homoplasmic/Heteroplasmic Variant Calling Pipeline for Alzheimer’s Disease Sequencing Project. J Alzheimers Dis Rep. 2024;8(1):575-87. Epub 20240408. doi: 10.3233/adr-230120. (PubMed PMID: 38746629; PMCID: PMC11091720).

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May

Aghilinejad A, Gharib M. Assessing pressure wave components for aortic stiffness monitoring through spectral regression learning. Eur Heart J Open. 2024;4(3):oeae040. Epub 20240521. doi: 10.1093/ehjopen/oeae040. (PubMed PMID: 38863521; PMCID: PMC11165314).

Almidani L, Sabharwal J, Shahidzadeh A, Martinez AC, Ting SJ, Vaidya B, Jiang X, Kowalczyk T, Beiser A, Sobrin L, Seshadri S, Ramulu P, Kashani AH. Biological and Methodological Variability in Retinal Nerve Fiber Layer OCT: The Framingham Heart Study. Ophthalmol Sci. 2024;4(6):100549. Epub 20240506. doi: 10.1016/j.xops.2024.100549. (PubMed PMID: 39161752; PMCID: PMC11331915).

Carbonneau M, Li Y, Prescott B, Liu C, Huan T, Joehanes R, Murabito JM, Heard-Costa NL, Xanthakis V, Levy D, Ma J. Epigenetic Age Mediates the Association of Life’s Essential 8 With Cardiovascular Disease and Mortality. J Am Heart Assoc. 2024;13(11):e032743. Epub 20240529. doi: 10.1161/jaha.123.032743. (PubMed PMID: 38808571; PMCID: PMC11255626).

Cooper LL, Prescott BR, Xanthakis V, Benjamin EJ, Vasan RS, Hamburg NM, Long MT, Mitchell GF. Association of Aortic Stiffness and Pressure Pulsatility With Noninvasive Estimates of Hepatic Steatosis and Fibrosis: The Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2024;44(7):1704-15. Epub 20240516. doi: 10.1161/atvbaha.123.320553. (PubMed PMID: 38752348; PMCID: PMC11209780).

de Vries PS, Reventun P, Brown MR, Heath AS, Huffman JE, Le NQ, Bebo A, Brody JA, Temprano-Sagrera G, Raffield LM, Ozel AB, Thibord F, Jain D, Lewis JP, Rodriguez BAT, Pankratz N, Taylor KD, Polasek O, Chen MH, Yanek LR, Carrasquilla GD, Marioni RE, Kleber ME, Trégouët DA, Yao J, Li-Gao R, Joshi PK, Trompet S, Martinez-Perez A, Ghanbari M, Howard TE, Reiner AP, Arvanitis M, Ryan KA, Bartz TM, Rudan I, Faraday N, Linneberg A, Ekunwe L, Davies G, Delgado GE, Suchon P, Guo X, Rosendaal FR, Klaric L, Noordam R, van Rooij F, Curran JE, Wheeler MM, Osburn WO, O’Connell JR, Boerwinkle E, Beswick A, Psaty BM, Kolcic I, Souto JC, Becker LC, Hansen T, Doyle MF, Harris SE, Moissl AP, Deleuze JF, Rich SS, van Hylckama Vlieg A, Campbell H, Stott DJ, Soria JM, de Maat MPM, Almasy L, Brody LC, Auer PL, Mitchell BD, Ben-Shlomo Y, Fornage M, Hayward C, Mathias RA, Kilpeläinen TO, Lange LA, Cox SR, März W, Morange PE, Rotter JI, Mook-Kanamori DO, Wilson JF, van der Harst P, Jukema JW, Ikram MA, Blangero J, Kooperberg C, Desch KC, Johnson AD, Sabater-Lleal M, Lowenstein CJ, Smith NL, Morrison AC. A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels. Blood. 2024;143(18):1845-55. doi: 10.1182/blood.2023021452. (PubMed PMID: 38320121).

DeCarli C, Maillard P, Pase MP, Beiser AS, Kojis D, Satizabal CL, Himali JJ, Aparicio HJ, Fletcher E, Seshadri S. Trends in Intracranial and Cerebral Volumes of Framingham Heart Study Participants Born 1930 to 1970. JAMA Neurol. 2024;81(5):471-80. doi: 10.1001/jamaneurol.2024.0469. (PubMed PMID: 38526486; PMCID: PMC10964161).

Frederiksen TC, Benjamin EJ, Trinquart L, Lin H, Dahm CC, Christiansen MK, Jensen HK, Preis SR, Kornej J. Bidirectional Association Between Atrial Fibrillation and Myocardial Infarction, and Relation to Mortality in the Framingham Heart Study. J Am Heart Assoc. 2024;13(11):e032226. Epub 20240523. doi: 10.1161/jaha.123.032226. (PubMed PMID: 38780172; PMCID: PMC11255627).

Hickey J, Henao R, Wojdyla D, Pencina M, Engelhard M. Adaptive Discretization for Event PredicTion (ADEPT). Proc Mach Learn Res. 2024;238:1351-9. (PubMed PMID: 38725587; PMCID: PMC11078624).

Hrytsenko Y, Shea B, Elgart M, Kurniansyah N, Lyons G, Morrison AC, Carson AP, Haring B, Mitchell BD, Psaty BM, Jaeger BC, Gu CC, Kooperberg C, Levy D, Lloyd-Jones D, Choi E, Brody JA, Smith JA, Rotter JI, Moll M, Fornage M, Simon N, Castaldi P, Casanova R, Chung RH, Kaplan R, Loos RJF, Kardia SLR, Rich SS, Redline S, Kelly T, O’Connor T, Zhao W, Kim W, Guo X, Ida Chen YD, Sofer T. Machine learning models for predicting blood pressure phenotypes by combining multiple polygenic risk scores. Sci Rep. 2024;14(1):12436. Epub 20240530. doi: 10.1038/s41598-024-62945-9. (PubMed PMID: 38816422; PMCID: PMC11139858).

Knol MJ, Poot RA, Evans TE, Satizabal CL, Mishra A, Sargurupremraj M, van der Auwera S, Duperron MG, Jian X, Hostettler IC, van Dam-Nolen DHK, Lamballais S, Pawlak MA, Lewis CE, Carrion-Castillo A, van Erp TGM, Reinbold CS, Shin J, Scholz M, Håberg AK, Kämpe A, Li GHY, Avinun R, Atkins JR, Hsu FC, Amod AR, Lam M, Tsuchida A, Teunissen MWA, Aygün N, Patel Y, Liang D, Beiser AS, Beyer F, Bis JC, Bos D, Bryan RN, Bülow R, Caspers S, Catheline G, Cecil CAM, Dalvie S, Dartigues JF, DeCarli C, Enlund-Cerullo M, Ford JM, Franke B, Freedman BI, Friedrich N, Green MJ, Haworth S, Helmer C, Hoffmann P, Homuth G, Ikram MK, Jack CR, Jr., Jahanshad N, Jockwitz C, Kamatani Y, Knodt AR, Li S, Lim K, Longstreth WT, Macciardi F, Mäkitie O, Mazoyer B, Medland SE, Miyamoto S, Moebus S, Mosley TH, Muetzel R, Mühleisen TW, Nagata M, Nakahara S, Palmer ND, Pausova Z, Preda A, Quidé Y, Reay WR, Roshchupkin GV, Schmidt R, Schreiner PJ, Setoh K, Shapland CY, Sidney S, St Pourcain B, Stein JL, Tabara Y, Teumer A, Uhlmann A, van der Lugt A, Vernooij MW, Werring DJ, Windham BG, Witte AV, Wittfeld K, Yang Q, Yoshida K, Brunner HG, Le Grand Q, Sim K, Stein DJ, Bowden DW, Cairns MJ, Hariri AR, Cheung CL, Andersson S, Villringer A, Paus T, Cichon S, Calhoun VD, Crivello F, Launer LJ, White T, Koudstaal PJ, Houlden H, Fornage M, Matsuda F, Grabe HJ, Ikram MA, Debette S, Thompson PM, Seshadri S, Adams HHH. Genetic variants for head size share genes and pathways with cancer. Cell Rep Med. 2024;5(5):101529. Epub 20240503. doi: 10.1016/j.xcrm.2024.101529. (PubMed PMID: 38703765; PMCID: PMC11148644).

Lu H, Lary CW, Hodonsky CJ, Peyser PA, Bos D, van der Laan SW, Miller CL, Rivadeneira F, Kiel DP, Kavousi M, Medina-Gomez C. Association between BMD and coronary artery calcification: an observational and Mendelian randomization study. J Bone Miner Res. 2024;39(4):443-52. doi: 10.1093/jbmr/zjae022. (PubMed PMID: 38477752; PMCID: PMC11262143).

Markov Y, Levine M, Higgins-Chen AT. Reliable detection of stochastic epigenetic mutations and associations with cardiovascular aging. Geroscience. 2024. Epub 20240513. doi: 10.1007/s11357-024-01191-3. (PubMed PMID: 38736015).

Martirosian RA, Wiedner CD, Sanchez J, Mun KT, Marla K, Teran C, Thirion M, Liebeskind DS, McGrath ER, Zucker JM, Bernal R, Beiser AS, DeCarli C, Himali JJ, Seshadri S, Hinman JD. Association of Incident Stroke Risk With an IL-18-Centered Inflammatory Network Biomarker Composite. Stroke. 2024;55(6):1601-8. Epub 20240501. doi: 10.1161/strokeaha.123.044719. (PubMed PMID: 38690658).

Møller AL, Larson M, Xanthakis V, Vasan RS, Andersson C. Modifiable risk factors and risk of myocardial infarction in offspring with parental disease. Eur J Prev Cardiol. 2024. Epub 20240509. doi: 10.1093/eurjpc/zwae169. (PubMed PMID: 38722824).

Murabito JM, Faro JM, Zhang Y, DeMalia A, Hamel A, Agyapong N, Liu H, Schramm E, McManus DD, Borrelli B. Smartphone App Designed to Collect Health Information in Older Adults: Usability Study. JMIR Hum Factors. 2024;11:e56653. Epub 20240530. doi: 10.2196/56653. (PubMed PMID: 38815261; PMCID: PMC11176875).

Pershad Y, Mack T, Poisner H, Jakubek YA, Stilp AM, Mitchell BD, Lewis JP, Boerwinkle E, Loos RJF, Chami N, Wang Z, Barnes K, Pankratz N, Fornage M, Redline S, Psaty BM, Bis JC, Shojaie A, Silverman EK, Cho MH, Yun JH, DeMeo D, Levy D, Johnson AD, Mathias RA, Taub MA, Arnett D, North KE, Raffield LM, Carson AP, Doyle MF, Rich SS, Rotter JI, Guo X, Cox NJ, Roden DM, Franceschini N, Desai P, Reiner AP, Auer PL, Scheet PA, Jaiswal S, Weinstock JS, Bick AG. Determinants of mosaic chromosomal alteration fitness. Nat Commun. 2024;15(1):3800. Epub 20240507. doi: 10.1038/s41467-024-48190-8. (PubMed PMID: 38714703; PMCID: PMC11076528).

Ravichandran S, Gajjar P, Walker ME, Prescott B, Tsao CW, Jha M, Rao P, Miller P, Larson MG, Vasan RS, Shah RV, Xanthakis V, Lewis GD, Nayor M. Life’s Essential 8 Cardiovascular Health Score and Cardiorespiratory Fitness in the Community. J Am Heart Assoc. 2024;13(9):e032944. Epub 20240503. doi: 10.1161/jaha.123.032944. (PubMed PMID: 38700001; PMCID: PMC11179926).

Sargurupremraj M, Soumaré A, Bis JC, Surakka I, Jürgenson T, Joly P, Knol MJ, Wang R, Yang Q, Satizabal CL, Gudjonsson A, Mishra A, Bouteloup V, Phuah CL, van Duijn CM, Cruchaga C, Dufouil C, Chêne G, Lopez OL, Psaty BM, Tzourio C, Amouyel P, Adams HH, Jacqmin-Gadda H, Ikram MA, Gudnason V, Milani L, Winsvold BS, Hveem K, Matthews PM, Longstreth WT, Seshadri S, Launer LJ, Debette S. Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia. JAMA Netw Open. 2024;7(5):e2412824. Epub 20240501. doi: 10.1001/jamanetworkopen.2024.12824. (PubMed PMID: 38776079; PMCID: PMC11112447).

Szulc P, Dufour AB, Hannan MT, Kiel DP, Chapurlat R, Sornay-Rendu E, Merle B, Boyd SK, Whittier DE, Hanley DA, Goltzman D, Wong AKO, Lespessailles E, Khosla S, Ferrari S, Biver E, Bouxsein ML, Samelson EJ. Fracture risk based on high-resolution peripheral quantitative computed tomography measures does not vary with age in older adults-the bone microarchitecture international consortium prospective cohort study. J Bone Miner Res. 2024;39(5):561-70. doi: 10.1093/jbmr/zjae033. (PubMed PMID: 38477737; PMCID: PMC11205894).

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June

Aghilinejad A, Tamborini A, Gharib M. A new methodology for determining the central pressure waveform from peripheral measurement using Fourier-based machine learning. Artif Intell Med. 2024;154:102918. Epub 20240618. doi: 10.1016/j.artmed.2024.102918. (PubMed PMID: 38924863).

Ahangaran M, Zhu H, Li R, Yin L, Jang J, Chaudhry AP, Farrer LA, Au R, Kolachalama VB. DREAMER: a computational framework to evaluate readiness of datasets for machine learning. BMC Med Inform Decis Mak. 2024;24(1):152. Epub 20240604. doi: 10.1186/s12911-024-02544-w. (PubMed PMID: 38831432; PMCID: PMC11149315).

Alver SK, Pan S, Mossavar-Rahmani Y, Sotres-Alvarez D, Evenson KR, Floyd JS, Xanthakis V, Lin J, Cuthbertson C, Gallo LC, Cai J, Penedo FJ, Llabre MM, Matsushita K, Talavera GA, Pirzada A, Spartano N, Daviglus ML, Vasan RS, Kaplan RC. Physical Activity, Cardiovascular Status, Mortality, and Prediabetes in Hispanic and Non-Hispanic Adults. JAMA Netw Open. 2024;7(6):e2415094. Epub 20240603. doi: 10.1001/jamanetworkopen.2024.15094. (PubMed PMID: 38842811; PMCID: PMC11157354).

Amini S, Hao B, Yang J, Karjadi C, Kolachalama VB, Au R, Paschalidis IC. Prediction of Alzheimer’s disease progression within 6 years using speech: A novel approach leveraging language models. Alzheimers Dement. 2024;20(8):5262-70. Epub 20240625. doi: 10.1002/alz.13886. (PubMed PMID: 38924662; PMCID: PMC11350035).

Del Brutto VJ, Khasiyev F, Liu M, Spagnolo-Allende A, Qiao Y, Melgarejo Arias JD, Guzman VA, Igwe KC, Sanchez DL, Andrews H, Morales CD, Farrell MT, Bassil DT, Seshadri S, Wagner RG, Mngomezulu V, Manly J, Elkind MS, Berkman L, Romero JR, Maestre GE, Del Brutto OH, Brickman AM, Venketasubramanian N, Chen C, Robert C, Hilal S, Rundek T, Wasserman BA, Gutierrez J. Association of brain arterial diameters with demographic and anatomical factors in a multi-national pooled analysis of cohort studies. Neuroradiol J. 2024;37(3):304-13. Epub 20231226. doi: 10.1177/19714009231224429. (PubMed PMID: 38148489; PMCID: PMC11138338).

Grech J, Nkambule BB, Thibord F, Chan M, Lachapelle A, Vasan R, Spartano N, Chen MH, Nayor M, Lewis GD, Johnson AD. Cardiorespiratory Fitness Is Associated with Decreased Platelet Reactivity. Med Sci Sports Exerc. 2024. Epub 20240624. doi: 10.1249/mss.0000000000003502. (PubMed PMID: 38913957).

Hermes S, Cady J, Armentrout S, O’Connor J, Holdaway SC, Cruchaga C, Wingo T, Greytak EM. Epistatic Features and Machine Learning Improve Alzheimer’s Disease Risk Prediction Over Polygenic Risk Scores. J Alzheimers Dis. 2024;99(4):1425-40. doi: 10.3233/jad-230236. (PubMed PMID: 38788065; PMCID: PMC11284654).

Karlin H, Sooda M, Larson M, Rong J, Huan T, Mens MMJ, van Rooij FJA, Ikram MA, Courchesne P, Freedman JE, Joehanes R, Mueller GP, Kavousi M, Ghanbari M, Levy D. Plasma Extracellular MicroRNAs Associated With Cardiovascular Disease Risk Factors in Middle-Aged and Older Adults. J Am Heart Assoc. 2024;13(12):e033674. Epub 20240611. doi: 10.1161/jaha.123.033674. (PubMed PMID: 38860398; PMCID: PMC11255734).

Kwak SH, Hernandez-Cancela RB, DiCorpo DA, Condon DE, Merino J, Wu P, Brody JA, Yao J, Guo X, Ahmadizar F, Meyer M, Sincan M, Mercader JM, Lee S, Haessler J, Vy HMT, Lin Z, Armstrong ND, Gu S, Tsao NL, Lange LA, Wang N, Wiggins KL, Trompet S, Liu S, Loos RJF, Judy R, Schroeder PH, Hasbani NR, Bos MM, Morrison AC, Jackson RD, Reiner AP, Manson JE, Chaudhary NS, Carmichael LK, Chen YI, Taylor KD, Ghanbari M, van Meurs J, Pitsillides AN, Psaty BM, Noordam R, Do R, Park KS, Jukema JW, Kavousi M, Correa A, Rich SS, Damrauer SM, Hajek C, Cho NH, Irvin MR, Pankow JS, Nadkarni GN, Sladek R, Goodarzi MO, Florez JC, Chasman DI, Heckbert SR, Kooperberg C, Dupuis J, Malhotra R, de Vries PS, Liu CT, Rotter JI, Meigs JB. Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes. Diabetes Care. 2024;47(6):1042-7. doi: 10.2337/dc23-2274. (PubMed PMID: 38652672; PMCID: PMC11116923).

Lau ES, Zhao Y, Benjamin EJ, Ramachandran VS, Xanthakis V, Cheng S, Ho JE. Sex Differences in Left Ventricular Function and Cardiac Mechanics. J Am Heart Assoc. 2024;13(12):e035781. Epub 20240606. doi: 10.1161/jaha.124.035781. (PubMed PMID: 38842280; PMCID: PMC11255751).

Lteif D, Sreerama S, Bargal SA, Plummer BA, Au R, Kolachalama VB. Disease-driven domain generalization for neuroimaging-based assessment of Alzheimer’s disease. Hum Brain Mapp. 2024;45(8):e26707. doi: 10.1002/hbm.26707. (PubMed PMID: 38798082; PMCID: PMC11128757).

Medved S, Salinas J, Kojis D, Weinstein G, Vasan RS, Beiser A, Seshadri S. The association between levels of brain-derived neurotrophic factor and comorbid depression in patients with cardiovascular disease: The Framingham Heart Study. Psychiatry Clin Neurosci. 2024;78(8):438-45. Epub 20240606. doi: 10.1111/pcn.13664. (PubMed PMID: 38842141; PMCID: PMC11410362).

Miller PE, Gajjar P, Mitchell GF, Khan SS, Vasan RS, Larson MG, Lewis GD, Shah RV, Nayor M. Clusters of multidimensional exercise response patterns and estimated heart failure risk in the Framingham Heart Study. ESC Heart Fail. 2024. Epub 20240628. doi: 10.1002/ehf2.14797. (PubMed PMID: 38943268).

Neumann JT, Twerenbold R, Weimann J, Ballantyne CM, Benjamin EJ, Costanzo S, de Lemos JA, deFilippi CR, Di Castelnuovo A, Donfrancesco C, Dörr M, Eggers KM, Engström G, Felix SB, Ferrario MM, Gansevoort RT, Giampaoli S, Giedraitis V, Hedberg P, Iacoviello L, Jørgensen T, Kee F, Koenig W, Kuulasmaa K, Lewis JR, Lorenz T, Lyngbakken MN, Magnussen C, Melander O, Nauck M, Niiranen TJ, Nilsson PM, Olsen MH, Omland T, Oskarsson V, Palmieri L, Peters A, Prince RL, Qaderi V, Vasan RS, Salomaa V, Sans S, Smith JG, Söderberg S, Thorand B, Tonkin AM, Tunstall-Pedoe H, Veronesi G, Watanabe T, Watanabe M, Zeiher AM, Zeller T, Blankenberg S, Ojeda F. Prognostic Value of Cardiovascular Biomarkers in the Population. JAMA. 2024;331(22):1898-909. doi: 10.1001/jama.2024.5596. (PubMed PMID: 38739396; PMCID: PMC11091824).

Oelsner EC, Sun Y, Balte PP, Allen NB, Andrews H, Carson A, Cole SA, Coresh J, Couper D, Cushman M, Daviglus M, Demmer RT, Elkind MSV, Gallo LC, Gutierrez JD, Howard VJ, Isasi CR, Judd SE, Kanaya AM, Kandula NR, Kaplan RC, Kinney GL, Kucharska-Newton AM, Lackland DT, Lee JS, Make BJ, Min YI, Murabito JM, Norwood AF, Ortega VE, Pettee Gabriel K, Psaty BM, Regan EA, Sotres-Alvarez D, Schwartz D, Shikany JM, Thyagarajan B, Tracy RP, Umans JG, Vasan RS, Wenzel SE, Woodruff PG, Xanthakis V, Zhang Y, Post WS. Epidemiologic Features of Recovery From SARS-CoV-2 Infection. JAMA Netw Open. 2024;7(6):e2417440. Epub 20240603. doi: 10.1001/jamanetworkopen.2024.17440. (PubMed PMID: 38884994; PMCID: PMC11184459).

Ragab AAY, Doyle MF, Chen J, Fang Y, Lunetta KL, Murabito JM. Immune cell phenotypes and mortality in the Framingham Heart Study. Immun Ageing. 2024;21(1):37. Epub 20240612. doi: 10.1186/s12979-024-00431-6. (PubMed PMID: 38867269; PMCID: PMC11167945).

Sun N, Prescott B, Ma J, Mohanty A, Long MT, Walker ME. Prevalence of Steatotic Liver Disease Subtypes and Association With Metabolic Risk Factors in the Framingham Heart Study. Clin Gastroenterol Hepatol. 2024. Epub 20240609. doi: 10.1016/j.cgh.2024.05.030. (PubMed PMID: 38857746).

van Soest APM, de Groot L, Witkamp RF, van Lent DM, Seshadri S, van de Rest O. Concurrent nutrient deficiencies are associated with dementia incidence. Alzheimers Dement. 2024;20(7):4594-601. Epub 20240612. doi: 10.1002/alz.13884. (PubMed PMID: 38865433; PMCID: PMC11247665).

Zhang Y, Wang X, Pathiravasan CH, Spartano NL, Lin H, Borrelli B, Benjamin EJ, McManus DD, Larson MG, Vasan RS, Shah RV, Lewis GD, Liu C, Murabito JM, Nayor M. Association of Smartwatch-Based Heart Rate and Physical Activity With Cardiorespiratory Fitness Measures in the Community: Cohort Study. J Med Internet Res. 2024;26:e56676. Epub 20240613. doi: 10.2196/56676. (PubMed PMID: 38870519; PMCID: PMC11216017).

Zhao A, Balcer LJ, Himali JJ, O’Donnell A, Rahimpour Y, DeCarli C, Gonzales MM, Aparicio HJ, Ramos-Cejudo J, Kenney R, Beiser A, Seshadri S, Salinas J. Association of Loneliness with Functional Connectivity MRI, Amyloid-β PET, and Tau PET Neuroimaging Markers of Vulnerability for Alzheimer’s Disease. J Alzheimers Dis. 2024;99(4):1473-84. doi: 10.3233/jad-231425. (PubMed PMID: 38820017; PMCID: PMC11191473).

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July

Mega Vascular Cognitive Impairment and Dementia (MEGAVCID) consortium. A genome-wide association meta-analysis of all-cause and vascular dementia. Alzheimers Dement. 2024. Epub 20240724. doi: 10.1002/alz.14115. (PubMed PMID: 39046104).

Akhter-Khan SC, Tao Q, Ang TFA, Karjadi C, Itchapurapu IS, Libon DJ, Alosco M, Mez J, Qiu WQ, Au R. Cerebral Microbleeds in Different Brain Regions and Their Associations With the Digital Clock-Drawing Test: Secondary Analysis of the Framingham Heart Study. J Med Internet Res. 2024;26:e45780. Epub 20240729. doi: 10.2196/45780. (PubMed PMID: 39073857; PMCID: PMC11319892).

Gonzales MM, Kojis D, Spartano NL, Thibault EG, DeCarli CS, El Fakhri G, Johnson KA, Beiser AS, Seshadri S. Associations of Physical Activity Engagement with Cerebral Amyloid-β and Tau from Midlife. J Alzheimers Dis. 2024;100(3):935-43. doi: 10.3233/jad-240322. (PubMed PMID: 39031362).

Gonzales MM, O’Donnell A, Ghosh S, Thibault E, Tanner J, Satizabal CL, Decarli CS, Fakhri GE, Johnson KA, Beiser AS, Seshadri S, Pase M. Associations of cerebral amyloid beta and tau with cognition from midlife. Alzheimers Dement. 2024. Epub 20240722. doi: 10.1002/alz.14060. (PubMed PMID: 39039896).

Kang M, Li C, Mahajan A, Spat-Lemus J, Durape S, Chen J, Gurnani AS, Devine S, Auerbach SH, Ang TFA, Sherva R, Qiu WQ, Lunetta KL, Au R, Farrer LA, Mez J. Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment. JAMA Psychiatry. 2024. Epub 20240703. doi: 10.1001/jamapsychiatry.2024.1678. (PubMed PMID: 38959008; PMCID: PMC11223054).

Kentistou KA, Kaisinger LR, Stankovic S, Vaudel M, Mendes de Oliveira E, Messina A, Walters RG, Liu X, Busch AS, Helgason H, Thompson DJ, Santoni F, Petricek KM, Zouaghi Y, Huang-Doran I, Gudbjartsson DF, Bratland E, Lin K, Gardner EJ, Zhao Y, Jia RY, Terao C, Riggan MJ, Bolla MK, Yazdanpanah M, Yazdanpanah N, Bradfield JP, Broer L, Campbell A, Chasman DI, Cousminer DL, Franceschini N, Franke LH, Girotto G, He C, Järvelin MR, Joshi PK, Kamatani Y, Karlsson R, Luan J, Lunetta KL, Mägi R, Mangino M, Medland SE, Meisinger C, Noordam R, Nutile T, Concas MP, Polašek O, Porcu E, Ring SM, Sala C, Smith AV, Tanaka T, van der Most PJ, Vitart V, Wang CA, Willemsen G, Zygmunt M, Ahearn TU, Andrulis IL, Anton-Culver H, Antoniou AC, Auer PL, Barnes CLK, Beckmann MW, Berrington de Gonzalez A, Bogdanova NV, Bojesen SE, Brenner H, Buring JE, Canzian F, Chang-Claude J, Couch FJ, Cox A, Crisponi L, Czene K, Daly MB, Demerath EW, Dennis J, Devilee P, De Vivo I, Dörk T, Dunning AM, Dwek M, Eriksson JG, Fasching PA, Fernandez-Rhodes L, Ferreli L, Fletcher O, Gago-Dominguez M, García-Closas M, García-Sáenz JA, González-Neira A, Grallert H, Guénel P, Haiman CA, Hall P, Hamann U, Hakonarson H, Hart RJ, Hickey M, Hooning MJ, Hoppe R, Hopper JL, Hottenga JJ, Hu FB, Huebner H, Hunter DJ, Jernström H, John EM, Karasik D, Khusnutdinova EK, Kristensen VN, Lacey JV, Lambrechts D, Launer LJ, Lind PA, Lindblom A, Magnusson PKE, Mannermaa A, McCarthy MI, Meitinger T, Menni C, Michailidou K, Millwood IY, Milne RL, Montgomery GW, Nevanlinna H, Nolte IM, Nyholt DR, Obi N, O’Brien KM, Offit K, Oldehinkel AJ, Ostrowski SR, Palotie A, Pedersen OB, Peters A, Pianigiani G, Plaseska-Karanfilska D, Pouta A, Pozarickij A, Radice P, Rennert G, Rosendaal FR, Ruggiero D, Saloustros E, Sandler DP, Schipf S, Schmidt CO, Schmidt MK, Small K, Spedicati B, Stampfer M, Stone J, Tamimi RM, Teras LR, Tikkanen E, Turman C, Vachon CM, Wang Q, Winqvist R, Wolk A, Zemel BS, Zheng W, van Dijk KW, Alizadeh BZ, Bandinelli S, Boerwinkle E, Boomsma DI, Ciullo M, Chenevix-Trench G, Cucca F, Esko T, Gieger C, Grant SFA, Gudnason V, Hayward C, Kolčić I, Kraft P, Lawlor DA, Martin NG, Nøhr EA, Pedersen NL, Pennell CE, Ridker PM, Robino A, Snieder H, Sovio U, Spector TD, Stöckl D, Sudlow C, Timpson NJ, Toniolo D, Uitterlinden A, Ulivi S, Völzke H, Wareham NJ, Widen E, Wilson JF, Pharoah PDP, Li L, Easton DF, Njølstad PR, Sulem P, Murabito JM, Murray A, Manousaki D, Juul A, Erikstrup C, Stefansson K, Horikoshi M, Chen Z, Farooqi IS, Pitteloud N, Johansson S, Day FR, Perry JRB, Ong KK. Understanding the genetic complexity of puberty timing across the allele frequency spectrum. Nat Genet. 2024;56(7):1397-411. Epub 20240701. doi: 10.1038/s41588-024-01798-4. (PubMed PMID: 38951643; PMCID: PMC11250262).

Kim H, Chen J, Prescott B, Walker ME, Grams ME, Yu B, Vasan RS, Floyd JS, Sotoodehnia N, Smith NL, Arking DE, Coresh J, Rebholz CM. Plasma proteins associated with plant-based diets: Results from the Atherosclerosis Risk in Communities (ARIC) study and Framingham Heart Study (FHS). Clin Nutr. 2024;43(8):1929-40. Epub 20240714. doi: 10.1016/j.clnu.2024.07.005. (PubMed PMID: 39018652; PMCID: PMC11342917).

Kovbasyuk Z, Ramos-Cejudo J, Parekh A, Bubu OM, Ayappa IA, Varga AW, Chen MH, Johnson AD, Gutierrez-Jimenez E, Rapoport DM, Osorio RS. Obstructive Sleep Apnea, Platelet Aggregation, and Cardiovascular Risk. J Am Heart Assoc. 2024;13(15):e034079. Epub 20240726. doi: 10.1161/jaha.123.034079. (PubMed PMID: 39056328).

Lee MM, Zuo Y, Steiling K, Mizgerd JP, Kalesan B, Walkey AJ. Clinical risk factors and blood protein biomarkers of 10-year pneumonia risk. PLoS One. 2024;19(7):e0296139. Epub 20240705. doi: 10.1371/journal.pone.0296139. (PubMed PMID: 38968193; PMCID: PMC11226120).

Marquardt JP, Tonnesen PE, Mercaldo ND, Graur A, Allaire B, Bouxsein ML, Samelson EJ, Kiel DP, Fintelmann FJ. Subcutaneous and Visceral Adipose Tissue Reference Values From the Framingham Heart Study Thoracic and Abdominal CT. Invest Radiol. 2024. Epub 20240725. doi: 10.1097/rli.0000000000001104. (PubMed PMID: 39047288).

Mbatchou J, McPeek MS. JASPER: Fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expression. Am J Hum Genet. 2024;111(8):1750-69. Epub 20240717. doi: 10.1016/j.ajhg.2024.06.010. (PubMed PMID: 39025064; PMCID: PMC11339629).

Ramos-Cejudo J, Scott MR, Tanner JA, Pase MP, McGrath ER, Ghosh S, Osorio RS, Thibault E, El Fakhri G, Johnson KA, Beiser A, Seshadri S. Associations of Plasma Tau with Amyloid and Tau PET: Results from the Community-Based Framingham Heart Study. J Alzheimers Dis. 2024;100(2):487-94. doi: 10.3233/jad-231320. (PubMed PMID: 38875034).

Spartano NL, Zhang Y, Liu C, Chernofsky A, Lin H, Trinquart L, Borrelli B, Pathiravasan CH, Kheterpal V, Nowak C, Vasan RS, Benjamin EJ, McManus DD, Murabito JM. Agreement Between Apple Watch and Actical Step Counts in a Community Setting: Cross-Sectional Investigation From the Framingham Heart Study. JMIR Biomed Eng. 2024;9:e54631. Epub 20240724. doi: 10.2196/54631. (PubMed PMID: 39047284; PMCID: PMC11306942).

van Gils V, Tao Q, Ang TFA, Young CB, Mormino EC, Qiu WQ, Visser PJ, Au R, Jansen WJ, Vos SJB. Associations Between Glucose Metabolism Measures and Amyloid-β and Tau Load on PET 14 Years Later: Findings From the Framingham Heart Study. Diabetes Care. 2024. Epub 20240730. doi: 10.2337/dc24-0162. (PubMed PMID: 39078159).

Xue C, Kowshik SS, Lteif D, Puducheri S, Jasodanand VH, Zhou OT, Walia AS, Guney OB, Zhang JD, Pham ST, Kaliaev A, Andreu-Arasa VC, Dwyer BC, Farris CW, Hao H, Kedar S, Mian AZ, Murman DL, O’Shea SA, Paul AB, Rohatgi S, Saint-Hilaire MH, Sartor EA, Setty BN, Small JE, Swaminathan A, Taraschenko O, Yuan J, Zhou Y, Zhu S, Karjadi C, Alvin Ang TF, Bargal SA, Plummer BA, Poston KL, Ahangaran M, Au R, Kolachalama VB. AI-based differential diagnosis of dementia etiologies on multimodal data. Nat Med. 2024. Epub 20240704. doi: 10.1038/s41591-024-03118-z. (PubMed PMID: 38965435).

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August

Bilgic S, Pencina KM, Pencina MJ, Cole J, Dufresne L, Thanassoulis G, Sniderman AD. Discordance Analysis of VLDL-C and ApoB in UK Biobank and Framingham Study: A Prospective Observational Study. Arterioscler Thromb Vasc Biol. 2024. Epub 20240815. doi: 10.1161/atvbaha.124.321165. (PubMed PMID: 39145394).

Charisis S, Short MI, Bernal R, Kautz TF, Treviño HA, Mathews J, Dediós AGV, Muhammad JAS, Luckey AM, Aslam A, Himali JJ, Shipp EL, Habes M, Beiser AS, DeCarli C, Scarmeas N, Ramachandran VS, Seshadri S, Maillard P, Satizabal CL. Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age. Alzheimers Dement. 2024. Epub 20240812. doi: 10.1002/alz.13879. (PubMed PMID: 39132759).

Ding H, Lister A, Karjadi C, Au R, Lin H, Bischoff B, Hwang PH. Detection of Mild Cognitive Impairment From Non-Semantic, Acoustic Voice Features: The Framingham Heart Study. JMIR Aging. 2024;7:e55126. Epub 20240822. doi: 10.2196/55126. (PubMed PMID: 39173144; PMCID: PMC11377909).

Eromosele OB, Shapira-Daniels A, Yuan A, Lukan A, Akinrimisi O, Chukwurah M, Nayor M, Benjamin EJ, Lin H. The association of exhaled carbon monoxide with atrial fibrillation and left atrial size in the Framingham Heart Study. Am Heart J Plus. 2024;45:100439. Epub 20240808. doi: 10.1016/j.ahjo.2024.100439. (PubMed PMID: 39234302; PMCID: PMC11372625).

Gaye B, Valentin E, Xanthakis V, Perier MC, Celermajer DS, Shipley M, Marijon E, Song RJ, Empana JP, Ramachandran VS, Jouven X. Association between change in heart rate over years and life span in the Paris Prospective 1, the Whitehall 1, and Framingham studies. Sci Rep. 2024;14(1):20052. Epub 20240829. doi: 10.1038/s41598-024-70806-8. (PubMed PMID: 39209972; PMCID: PMC11362490).

Guan Y, Levy D. Asymptotically Exact Fit for Linear Mixed Model in Genetic Association Studies. Genetics. 2024. Epub 20240830. doi: 10.1093/genetics/iyae143. (PubMed PMID: 39212459).

Jiang MZ, Gaynor SM, Li X, Van Buren E, Stilp A, Buth E, Wang FF, Manansala R, Gogarten SM, Li Z, Polfus LM, Salimi S, Bis JC, Pankratz N, Yanek LR, Durda P, Tracy RP, Rich SS, Rotter JI, Mitchell BD, Lewis JP, Psaty BM, Pratte KA, Silverman EK, Kaplan RC, Avery C, North KE, Mathias RA, Faraday N, Lin H, Wang B, Carson AP, Norwood AF, Gibbs RA, Kooperberg C, Lundin J, Peters U, Dupuis J, Hou L, Fornage M, Benjamin EJ, Reiner AP, Bowler RP, Lin X, Auer PL, Raffield LM. Whole genome sequencing based analysis of inflammation biomarkers in the Trans-Omics for Precision Medicine (TOPMed) consortium. Hum Mol Genet. 2024;33(16):1429-41. doi: 10.1093/hmg/ddae050. (PubMed PMID: 38747556; PMCID: PMC11305684).

Pirruccello JP, Khurshid S, Lin H, Weng LC, Zamirpour S, Kany S, Raghavan A, Koyama S, Vasan RS, Benjamin EJ, Lindsay ME, Ellinor PT. The AORTA Gene score for detection and risk stratification of ascending aortic dilation. Eur Heart J. 2024. Epub 20240812. doi: 10.1093/eurheartj/ehae474. (PubMed PMID: 39132911).

Rao P, Keyes MJ, Mi MY, Barber JL, Tahir UA, Deng S, Clish CB, Shen D, Farrell LA, Wilson JG, Gao Y, Yimer WK, Ekunwe L, Hall ME, Muntner PM, Guo X, Taylor KD, Tracy RP, Rich SS, Rotter JI, Xanthakis V, Vasan RS, Bouchard C, Sarzynski MA, Gerszten RE, Robbins JM. Plasma Proteomics of Exercise Blood Pressure and Incident Hypertension. JAMA Cardiol. 2024;9(8):713-22. doi: 10.1001/jamacardio.2024.1397. (PubMed PMID: 38865108; PMCID: PMC11170454).

Usiskin IM, Mitchell GF, Bouxsein ML, Liu CT, Kiel DP, Samelson EJ. Vascular function and skeletal fragility: a study of tonometry, brachial hemodynamics, and bone microarchitecture. J Bone Miner Res. 2024;39(7):906-17. doi: 10.1093/jbmr/zjae071. (PubMed PMID: 38709885; PMCID: PMC11301519).

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September

Acharya S, Liao S, Jung WJ, Kang YS, Moghaddam VA, Feitosa MF, Wojczynski MK, Lin S, Anema JA, Schwander K, Connell JO, Province MA, Brent MR. A methodology for gene level omics-WAS integration identifies genes influencing traits associated with cardiovascular risks: the Long Life Family Study. Hum Genet. 2024;143(9-10):1241-52. Epub 20240914. doi: 10.1007/s00439-024-02701-1. (PubMed PMID: 39276247; PMCID: PMC11485042).

Ahmad S, Imtiaz MA, Mishra A, Wang R, Herrera-Rivero M, Bis JC, Fornage M, Roshchupkin G, Hofer E, Logue M, Longstreth WT, Jr., Xia R, Bouteloup V, Mosley T, Launer LJ, Khalil M, Kuhle J, Rissman RA, Chene G, Dufouil C, Djoussé L, Lyons MJ, Mukamal KJ, Kremen WS, Franz CE, Schmidt R, Debette S, Breteler MMB, Berger K, Yang Q, Seshadri S, Aziz NA, Ghanbari M, Ikram MA. Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration. Commun Biol. 2024;7(1):1103. Epub 20240909. doi: 10.1038/s42003-024-06804-3. (PubMed PMID: 39251807; PMCID: PMC11385583).

Chen J, Ragab AAY, Doyle MF, Alosco ML, Fang Y, Mez J, Satizabal CL, Qiu WQ, Murabito JM, Lunetta KL. Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort. Alzheimers Dement. 2024. Epub 20240916. doi: 10.1002/alz.14147. (PubMed PMID: 39282876).

Huan T, Joehanes R, Rong J, Chen MH, Mustafa R, Dehghan A, Ghanbari M, Karlin H, Hwang SJ, Courchesne P, Larson MG, Johnson AD, Freedman JE, Levy D. Expression quantitative trait locus mapping of extracellular microRNAs in human plasma. iScience. 2024;27(10):110988. Epub 20240918. doi: 10.1016/j.isci.2024.110988. (PubMed PMID: 39398240; PMCID: PMC11471191).

Huffman JE, Nicholas J, Hahn J, Heath AS, Raffield LM, Yanek LR, Brody JA, Thibord F, Almasy L, Bartz TM, Bielak LF, Bowler RP, Carrasquilla GD, Chasman DI, Chen MH, Emmert DB, Ghanbari M, Haessler J, Hottenga JJ, Kleber ME, Le NQ, Lee J, Lewis JP, Li-Gao R, Luan J, Malmberg AL, Mangino M, Marioni R, Martinez-Perez A, Pankratz N, Polasek O, Richmond A, Rodriguez BAT, Rotter JI, Steri M, Suchon P, Trompet S, Weiss S, Zare M, Auer PL, Cho M, Christofidou P, Davies G, de Geus EJ, Deleuze JF, Delgado GE, Ekunwe L, Faraday N, Gogele M, Greinacher A, Gao H, Howard TE, Joshi PK, Kilpeläinen TO, Lahti J, Linneberg A, Naitza S, Noordam R, Vergés FP, Rich SS, Rosendaal FR, Rudan I, Ryan KA, Souto JCC, van Rooij FJA, Wang H, Zhao W, Becker L, Beswick A, Brown MR, Cade B, Campbell H, Cho K, Crapo J, Curran J, de Maat MPM, Doyle MF, Elliott P, Floyd JS, Fuchsberger C, Grarup N, Guo X, Harris S, Hou L, Kolcic I, Kooperberg C, Menni C, Nauck M, O’Connell JR, Orru V, Psaty BM, Räikkönen K, Smith JA, Soria JM, Stott D, van Hylckama Vlieg A, Watkins H, Willemsen G, Wilson PW, Ben-Shlomo Y, Blangero J, Boomsma D, Cox SR, Dehghan A, Eriksson JG, Fiorillo E, Fornage M, Hansen T, Hayward C, Ikram MA, Jukema JW, Kardia S, Lange L, Maerz W, Mathias R, Mitchell BD, Mook-Kanamori DO, Morange PE, Pedersen O, Pramstaller PP, Redline S, Reiner AP, Ridker PM, Silverman EK, Spector TD, Volker U, Wareham N, Wilson J, Yao J, Tregouet DA, Johnson AD, Wolberg AS, de Vries PS, Sabater-Lleal M, Morrison A, Smith NL. Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles. Blood. 2024. Epub 20240903. doi: 10.1182/blood.2023022596. (PubMed PMID: 39226462).

Hussain A, Johansen MC, Blaha MJ, Al-Mallah MH, Cainzos-Achirica M, Nambi V, Rotter JI, Guo X, Yao J, Rich SS, Patel J, McEvoy JW, Nasir K, Gottesman R, Blumenthal RS, Ballantyne CM, Virani SS, Al Rifai M. Predictors of incident stroke among individuals without coronary artery calcification: A pooled cohort analysis from the Multi-Ethnic Study of Atherosclerosis, Jackson Heart Study, and Framingham Heart Study. Vasc Med. 2024:1358863×241270911. Epub 20240906. doi: 10.1177/1358863×241270911. (PubMed PMID: 39239865).

Sangani R, Lee MM, Xu H, Dupuis J, O’Connor GT. The Upper Limit of Normal Rate of Lung Function Decline in Healthy Adults in the Framingham Heart Study. CHEST Pulm. 2024;2(3). Epub 20240415. doi: 10.1016/j.chpulm.2024.100058. (PubMed PMID: 39421758; PMCID: PMC11484874).

Spartano NL, Sultana N, Lin H, Cheng H, Lu S, Fei D, Murabito JM, Walker ME, Wolpert HA, Steenkamp DW. Defining continuous glucose monitor time in range in a large community-based cohort without diabetes. J Clin Endocrinol Metab. 2024. Epub 20240911. doi: 10.1210/clinem/dgae626. (PubMed PMID: 39257191).

Sun X, Bulekova K, Yang J, Lai M, Pitsillides AN, Liu X, Zhang Y, Guo X, Yong Q, Raffield LM, Rotter JI, Rich SS, Abecasis G, Carson AP, Vasan RS, Bis JC, Psaty BM, Boerwinkle E, Fitzpatrick AL, Satizabal CL, Arking DE, Ding J, Levy D, Liu C. Association analysis of mitochondrial DNA heteroplasmic variants: Methods and application. Mitochondrion. 2024;79:101954. Epub 20240907. doi: 10.1016/j.mito.2024.101954. (PubMed PMID: 39245194).

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October

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December