Lab (Blood or Urine)
Lab (Blood or Urine)
| INFLAMMATORY MARKERS | ||||
|---|---|---|---|---|
| Phenotype | Heritability Estimate | PubMed & Heritability References | Genome-wide association studies |
|
| Age- and sex- adjusted | Multivariable- adjusted | |||
| C-reactive protein | 25.3% | 28.2% | PMID: 16159603 | PMID: 17903293 |
| Intercellular adhesion molecule-1 | 32.5% 25.7%±5.9% | 30.4% 24.3%±6% | PMID: 16159603 PMID: 15234428 |
PMID: 17903293 |
| Interleukin-6 | 25.4% | 13.7% | PMID: 16159603 | PMID: 17903293 |
| Urinary isoprostanes/urinary creatinine | ~12% | PMID: 12615693 | PMID: 17903293 | |
| Monocyte chemoattractant protein-1 | 45.2% | 44.0% | PMID: 16159603 | PMID: 17903293 |
| P-selectin | 45.4±5.8% | 45.4±5.8% | PMID: 17944986 | PMID: 17903293 PMID: 17903293 |
Metabolic, Hormonal
| DIABETES RELATED TRAITS | ||||||
|---|---|---|---|---|---|---|
| Phenotype | Heritability Estimate | PubMed & Heritability References | Genome-wide association studies |
|||
| Age-, age2 – and sex-adjusted |
||||||
| Quantitative trait | ||||||
| ln(fasting plasma glucose) | 34% | PMID: 11872688 | PMID: 11872688 | |||
| ln(HbA1c) | 47% | PMID: 11872688 | PMID: 11872688 | |||
| ln(time-averaged fasting plasma glucose) | 42% | PMID: 11872688 | PMID: 11872688 | |||
| ln(fasting insulin) | 41% | PMID: 12739029 | PMID: 12739029 | |||
| ln(Homeostasis model insulin resistance, HOMA-IR) | 42% | PMID: 12739029 | PMID: 12739029 | |||
| ln(Insulin sensitivity index, ISI_0-120) | 38% | unpublished | ||||
| ln(2-hr plasma glucose) | 33% | PMID: 11872688 | ||||
| ln(proinsulin) | 32% | unpublished | ||||
| ln(adiponectin) | 62% | unpublished | ||||
| ln(resistin) | 30% | unpublished | ||||
| ln(Tumor necrosis factor alpha) | 16% | unpublished | ||||
| VITAMINS | ||||||
|---|---|---|---|---|---|---|
| Phenotype | Heritability Estimate | PubMed & Heritability References | Genome-wide association studies |
|||
| Age- and sex- adjusted | Multivariable- adjusted |
|||||
| Plasma phylloquinone | 13.4±11.1% (P=0.11) | PMID: 18030310 | PMID: 17903293 | |||
| serum % undercarboxylated osteocalcin | 15.9±11.8%, P=0.08 | PMID: 18030310 | PMID: 17903293 | |||
| 25-hydroxyvitamin D | 28.8±11.3% | PMID: 18030310 | PMID: 17903293 | |||