Intermittent Claudication

Intermittent Claudication

Based on
Murabito JM, D’Agostino RB, Silbershatz H, Wilson PW. Intermittent claudication: a risk profile from the Framingham Heart Study. Circulation. 1997 Jul 1;96(1):44-9. PMID:9236415.

Outcome
Intermittent Claudication

Duration of follow-up
4-year intervals pooled for a total of 38 years

Population of interest
Inpiduals free of IC at the baseline examination

Predictors

  • Age
  • Sex
  • Serum cholesterol
  • Hypertension
  • Cigarette smoking
  • Diabetes
  • Coronary heart disease

4-Year Probability of Intermittent Claudication for Persons Aged 45-84 years

Risk Factor Risk Factor Points Line Score
0 +1 +2 +3 +4 +5 +6 +7
Age, y 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84
Sex Female Male
Cholesterol, mg/dL <170 170-209 210-249 250-289 >289
Blood pressure Normal High Normal Stage 1 Stage 2+
Cigarettes/d, n 0 1-5 6-10 11-20 >20
Diabetes No Yes
CHD No Yes
Point total
Points 4-Year Probability
<10 <1%
10-12 1%
13-15 2%
16-17 3%
18 4%
19 5%
20 6%
21 7%
22 8%
23 10%
24 11%
25 13%
26 16%
27 18%
28 21%
29 24%
30 28%

Stage 1 indicates stage 1 hypertension; stage 2+, greater than or equal to stage 2 hypertension; and CHD, coronary heart disease.

Logistic Regression coefficients for direct estimation of 4-year IC risk

Coefficients Used in the Intermittent
Claudication Prediction Chart
Variable Beta
Intercept -8.9152
Male sex 0.5033
Age 0.0372
Blood Pressure
Normal 0.0000
High Normal 0.2621
Stage 1 Hypertension 0.4067
Stage 2+ Hypertension 0.7977
Diabetes 0.9503
Cigarettes/d 0.0314
Cholesterol, mg/dL 0.0048
CHD 0.9939