FHS Bibliography – 2025

Framingham Heart Study Bibliography – 2025

January

Borghoff KA, Ounda AE, Swee ML, Girotra S, Shibli-Rahhal AA, Ten Eyck P, Jalal DI, Jovanovich AJ. Use of bisphosphonates in chronic kidney disease is associated with cardiovascular death. Clin Nephrol. 2025;103(1):5-11. doi: 10.5414/cn111428. (PubMed PMID: 39545393).

Florea VV, Gajjar P, Huang S, Tang J, Zhao S, Davenport M, Mi MY, Haff M, Zhang X, Miller PE, Vasan RS, Liu CT, Lewis GD, Shah RV, Long MT, Nayor M. Hepatic Steatosis and Fibrosis, Cardiorespiratory Fitness, and Metabolic Mediators in the Community. Liver Int. 2025;45(1):e16147. doi: 10.1111/liv.16147. (PubMed PMID: 39673712; PMCID: PMC11649011).

Guo MH, Lee WP, Vardarajan B, Schellenberg GD, Phillips-Cremins JE. Polygenic burden of short tandem repeat expansions promotes risk for Alzheimer’s disease. Nat Commun. 2025;16(1):1126. Epub 20250128. doi: 10.1038/s41467-025-56400-0. (PubMed PMID: 39875385; PMCID: PMC11775329).

Jakubek YA, Ma X, Stilp AM, Yu F, Bacon J, Wong JW, Aguet F, Ardlie K, Arnett DK, Barnes K, Bis JC, Blackwell T, Becker LC, Boerwinkle E, Bowler RP, Budoff MJ, Carson AP, Chen J, Cho MH, Coresh J, Cox NJ, de Vries PS, DeMeo DL, Fardo DW, Fornage M, Guo X, Hall ME, Heard-Costa N, Hidalgo B, Irvin MR, Johnson AD, Jorgenson E, Kenny EE, Kessler MD, Levy D, Li Y, Lima JAC, Liu Y, Locke AE, Loos RJF, Machiela MJ, Mathias RA, Mitchell BD, Murabito JM, Mychaleckyj JC, North KE, Orchard P, Parker SCJ, Pershad Y, Peyser PA, Pratte KA, Psaty BM, Raffield LM, Redline S, Rich SS, Rotter JI, Shah SJ, Smith JA, Smith AP, Smith A, Taub MA, Tiwari HK, Tracy R, Tuftin B, Bick AG, Sankaran VG, Reiner AP, Scheet P, Auer PL. Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood. Am J Hum Genet. 2025;112(2):276-90. Epub 20250113. doi: 10.1016/j.ajhg.2024.12.014. (PubMed PMID: 39809269; PMCID: PMC11866972).

Jo T, Bice P, Nho K, Saykin AJ. LD-informed deep learning for Alzheimer’s gene loci detection using WGS data. Alzheimers Dement (N Y). 2025;11(1):e70041. Epub 20250116. doi: 10.1002/trc2.70041. (PubMed PMID: 39822590; PMCID: PMC11736638).

Leng Y, Ding H, Ang TFA, Au R, Doraiswamy PM, Liu C. Identifying proteomic prognostic markers for Alzheimer’s disease with survival machine learning: The Framingham Heart Study. J Prev Alzheimers Dis. 2025;12(2):100021. Epub 20250101. doi: 10.1016/j.tjpad.2024.100021. (PubMed PMID: 39863332; PMCID: PMC12184055).

Little A, Zhao N, Mikhaylova A, Zhang A, Ling W, Thibord F, Johnson AD, Raffield LM, Curran JE, Blangero J, O’Connell JR, Xu H, Rotter JI, Rich SS, Rice KM, Chen MH, Reiner A, Kooperberg C, Vu T, Hou L, Fornage M, Loos RJF, Kenny E, Mathias R, Becker L, Smith AV, Boerwinkle E, Yu B, Thornton T, Wu MC. General Kernel Machine Methods for Multi-Omics Integration and Genome-Wide Association Testing With Related Individuals. Genet Epidemiol. 2025;49(1):e22610. doi: 10.1002/gepi.22610. (PubMed PMID: 39812506).

Magavern EF, Deshmukh H, Asselin G, Theusch E, Trompet S, Li X, Noordam R, Chen YI, Seeman TE, Taylor KD, Post WS, Tardif JC, Paul DS, Benjamin EJ, Heard-Costa NL, Vasan RS, Rotter JI, Krauss RM, Jukema JW, Ridker PM, Munroe PB, Caulfield MJ, Chasman DI, Dubé MP, Hitman GA, Warren HR. GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study. Pharmacol Res. 2025;212:107575. Epub 20250109. doi: 10.1016/j.phrs.2024.107575. (PubMed PMID: 39798939).

Muchira JM, Mogos MF, M SD, Kimathi B, Ziegler C, Heerman WJ, Hall KS. Allostatic Load in Parents and Offspring: Sex Differences and Intergenerational Effects on Cardiovascular Disease-Free Survival. J Cardiovasc Nurs. 2025. Epub 20250106. doi: 10.1097/jcn.0000000000001169. (PubMed PMID: 39757378).

Rade JJ, Kronsberg SS, Kickler TS, Vasan RS, Xanthakis V, Nayor MG, Barton BA. Association of Systemic Thromboxane Generation With Risk of Developing Heart Failure. J Am Coll Cardiol. 2025;85(1):58-70. doi: 10.1016/j.jacc.2024.09.010. (PubMed PMID: 39779056; PMCID: PMC12231177).

Raju S, Sierra P, Tejwani V, Staggers KA, McCormack M, Villareal DT, Rosas IO, Hanania NA, Wu TD. Association of Insulin Resistance With Radiographic Lung Abnormalities and Incident Lung Disease: The Framingham Offspring Study. Diabetes Care. 2025;48(1):143-8. doi: 10.2337/dc24-1754. (PubMed PMID: 39571139; PMCID: PMC11664196).

Sun N, Prescott B, Ma J, Xanthakis V, Quatromoni PA, Long MT, Walker ME. The cross-sectional association between ultra-processed food intake and metabolic dysfunction-associated steatotic liver disease. Clin Nutr ESPEN. 2025;66:215-20. Epub 20250127. doi: 10.1016/j.clnesp.2025.01.045. (PubMed PMID: 39880205).

Urbut SM, Cho SMJ, Paruchuri K, Truong B, Haidermota S, Peloso GM, Hornsby WE, Philippakis A, Fahed AC, Natarajan P. Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course. Circ Genom Precis Med. 2025;18(1):e004681. Epub 20250124. doi: 10.1161/circgen.124.004681. (PubMed PMID: 39851049; PMCID: PMC11835529).

van den Ende MWJ, Freichel R, van der Maas HLJ, Wiers RW, Epskamp S. Societal spirits in the silver streak: Unraveling complexity in drinking habits of the mature adult population. Alcohol Clin Exp Res (Hoboken). 2025;49(1):217-25. Epub 20250101. doi: 10.1111/acer.15486. (PubMed PMID: 39742440; PMCID: PMC11740162.

15. Vered S, Beiser AS, Sulimani L, Sznitman S, Ghosh S, Lewitus GM, Meiri D, Seshadri S, Weinstein G. Circulating Endocannabinoids and Cognitive Function in Older Adults. Aging Dis. 2025. Epub 20250106. doi: 10.14336/ad.2024.1427. (PubMed PMID: 39812547).

Weinstein G, Kojis D, Banerjee A, Seshadri S, Walker M, Beiser AS. Ultra-processed food consumption and risk of dementia and Alzheimer’s disease: The Framingham Heart Study. J Prev Alzheimers Dis. 2025;12(2):100042. Epub 20250101. doi: 10.1016/j.tjpad.2024.100042. (PubMed PMID: 39863327; PMCID: PMC12184002).

Weng LC, Rämö JT, Jurgens SJ, Khurshid S, Chaffin M, Hall AW, Morrill VN, Wang X, Nauffal V, Sun YV, Beer D, Lee S, Nadkarni GN, Duong T, Wang B, Czuba T, Austin TR, Yoneda ZT, Friedman DJ, Clayton A, Hyman MC, Judy RL, Skanes AC, Orland KM, Treu TM, Oetjens MT, Alonso A, Soliman EZ, Lin H, Lunetta KL, van der Pals J, Issa TZ, Nafissi NA, May HT, Leong-Sit P, Roselli C, Choi SH, Khan HR, Knight S, Karlsson Linnér R, Bezzina CR, Ripatti S, Heckbert SR, Gaziano JM, Loos RJF, Psaty BM, Smith JG, Benjamin EJ, Arking DE, Rader DJ, Shah SH, Roden DM, Damrauer SM, Eckhardt LL, Roberts JD, Cutler MJ, Shoemaker MB, Haggerty CM, Cho K, Palotie A, Wilson PWF, Ellinor PT, Lubitz SA. The impact of common and rare genetic variants on bradyarrhythmia development. Nat Genet. 2025;57(1):53-64. Epub 20250102. doi: 10.1038/s41588-024-01978-2. (PubMed PMID: 39747593; PMCID: PMC11735381).

Yao Z, Tasdighi E, Dardari ZA, Jha KK, Osuji N, Rajan T, Boakye E, Rodriguez CJ, Matsushita K, Simonsick EM, Lima JAC, Widome R, Cohen DL, Appel LJ, Khera A, Hall ME, Judd S, Cole SA, Vasan RS, Benjamin EJ, Bhatnagar A, DeFilippis AP, Blaha MJ. Differential Associations of Cigar, Pipe, and Smokeless Tobacco Use Versus Combustible Cigarette Use With Subclinical Markers of Inflammation, Thrombosis, and Atherosclerosis: The Cross-Cohort Collaboration-Tobacco Working Group. Circulation. 2025;151(14):993-1005. Epub 20250127. doi: 10.1161/circulationaha.124.070852. (PubMed PMID: 39866105; PMCID: PMC11975489).

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February

Ahangaran M, Dawalatabad N, Karjadi C, Glass J, Au R, Kolachalama VB. Obfuscation via pitch-shifting for balancing privacy and diagnostic utility in voice-based cognitive assessment. Alzheimers Dement. 2025;21(3):e70032. doi: 10.1002/alz.70032. (PubMed PMID: 40084735; PMCID: PMC12045024).

Cheng YJ, Deng H, Wei HQ, Lin WD, Liang Z, Chen Y, Dong Y, Fang XH, Liao HT, Wu SL, Liu FZ, Xue YM, Wu Z. Association Between Age at Diagnosis of Atrial Fibrillation and Subsequent Risk of Ischemic Stroke. J Am Heart Assoc. 2025;14(4):e038367. Epub 20250208. doi: 10.1161/jaha.124.038367. (PubMed PMID: 39921524; PMCID: PMC12074760).

Cooper LL, Majid S, Wang N, Fetterman JL, Palmisano JN, Benjamin EJ, Vasan RS, Mitchell GF, Hamburg NM. Cross-sectional and longitudinal associations of smoking behaviour with central arterial haemodynamic measures: the Framingham Heart Study. Eur J Prev Cardiol. 2025. Epub 20250205. doi: 10.1093/eurjpc/zwaf012. (PubMed PMID: 39907713).

Ekenze O, Seiler S, Pinheiro A, DeCarli C, Parva P, Habes M, Charidimou A, Maillard P, Beiser A, Seshadri S, Demissie S, Romero JR. Relation of MRI visible perivascular spaces with global and regional brain structural connectivity measures: The Framingham Heart Study (FHS). Neurobiol Aging. 2025;150:1-8. Epub 20250227. doi: 10.1016/j.neurobiolaging.2025.02.007. (PubMed PMID: 40043467; PMCID: PMC11981825).

Franco WG, O’Keefe EL, O’Keefe JH, Tintle N, Marchioli R, Harris WS. Omega-3 index improves upon the pooled cohort equation in predicting risk for CVD. J Clin Lipidol. 2025;19(2):286-93. Epub 20250203. doi: 10.1016/j.jacl.2024.12.005. (PubMed PMID: 40074603; PMCID: PMC12101608).

Li J, Liu C, Ang TFA, Au R. Associations of Mid- and Late-Life Fasting Blood Glucose Levels With Dementia Risk Among Patients With Diabetes: Framingham Heart Study. Eur J Neurol. 2025;32(2):e70062. doi: 10.1111/ene.70062. (PubMed PMID: 39910859; PMCID: PMC11799049).

Li X, Chen H, Selvaraj MS, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Jiang MZ, DiCorpo D, Gaynor SM, Dey R, Arnett DK, Benjamin EJ, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Carson AP, Carlson JC, Chami N, Chen YI, Curran JE, de Vries PS, Fornage M, Franceschini N, Freedman BI, Gu C, Heard-Costa NL, He J, Hou L, Hung YJ, Irvin MR, Kaplan RC, Kardia SLR, Kelly TN, Konigsberg I, Kooperberg C, Kral BG, Li C, Li Y, Lin H, Liu CT, Loos RJF, Mahaney MC, Martin LW, Mathias RA, Mitchell BD, Montasser ME, Morrison AC, Naseri T, North KE, Palmer ND, Peyser PA, Psaty BM, Redline S, Reiner AP, Rich SS, Sitlani CM, Smith JA, Taylor KD, Tiwari HK, Vasan RS, Viali S, Wang Z, Wessel J, Yanek LR, Yu B, Dupuis J, Meigs JB, Auer PL, Raffield LM, Manning AK, Rice KM, Rotter JI, Peloso GM, Natarajan P, Li Z, Liu Z, Lin X. A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies. Nat Comput Sci. 2025;5(2):125-43. Epub 20250207. doi: 10.1038/s43588-024-00764-8. (PubMed PMID: 39920506; PMCID: PMC11981678).

Mandava M, Reddy Vinta S. EBHOA-EMobileNetV2: a hybrid system based on efficient feature selection and classification for cardiovascular disease diagnosis. Comput Methods Biomech Biomed Engin. 2025:1-23. Epub 20250219. doi: 10.1080/10255842.2025.2466081. (PubMed PMID: 39970065).

Mondal S, Maity R, Nag A. An efficient artificial neural network-based optimization techniques for the early prediction of coronary heart disease: comprehensive analysis. Sci Rep. 2025;15(1):4827. Epub 20250209. doi: 10.1038/s41598-025-85765-x. (PubMed PMID: 39924575; PMCID: PMC11808106).

Oelsner EC, Krishnaswamy A, Rustamov R, Balte PP, Ali T, Allen NB, Andrews HF, Anugu P, Arynchyn A, Bateman LA, Cai J, Chang H, Chen L, Elkind MSV, Floyd JS, Gabriel KP, Gharib SA, Gutierrez JD, Stukovsky KH, Howard VJ, Isasi CR, Jager L, Jin L, Judd SE, Kanaya AM, Kandula NR, Kelly MR, Khan SS, Kucharska-Newton A, Lee JS, Levitan EB, Lewis CE, Make BJ, Malloy K, Manly JJ, Mauger D, Min YI, Murabito JM, Murphy CG, Norwood AF, O’Connor GT, Ortega VE, Patel AA, Pirzada A, Regan EA, Ring KB, Rosamond WD, Schwartz DA, Shikany JM, Sotres-Alvarez D, Tarlton C, Tse J, Meneses EMU, Vankineni M, Wenzel SE, Woodruff PG, Xanthakis V, Yang JH, Zakai NA, Zhang Y, Post WS. Classifying COVID-19 hospitalizations in epidemiology cohort studies: The C4R study. PloS One. 2025;20(2):e0316198. Epub 20250210. doi: 10.1371/journal.pone.0316198. (PubMed PMID: 39928595; PMCID: PMC11809881).

Wang S, Lenzini P, Thyagarajan B, Lee JH, Vardarajan BN, Yashin A, Miljkovic I, Daw EW, Lin SJ, Patti GJ, Brent MR, Zmuda JM, Perls TT, Christensen K, Province MA, An P. Evidence of a novel gene locus ARHGAP44 for longitudinal change in hemoglobin A1c levels among subjects without diabetes from the Long Life Family Study. Physiol Genomics. 2025;57(5):293-8. Epub 20250228. doi: 10.1152/physiolgenomics.00137.2024. (PubMed PMID: 40019798; PMCID: PMC12182963).

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March

Ai M, Otokozawa S, Liu CT, Asztalos BF, Maddalena J, Diffenderfer MR, Russo G, Thongtang N, Dansinger ML. Diabetes Mellitus Risk Prediction in the Framingham Offspring Study and Large Population Analysis. Nutrients. 2025;17(7). Epub 20250324. doi: 10.3390/nu17071117. (PubMed PMID: 40218874; PMCID: PMC11990307).

Bhatt SP, Wu C, Sun Y, Balte PP, Schwartz JE, Divo MJ, Jaeger BC, Chaves PH, Couper D, Jacobs DR, Jr., Lloyd-Jones D, Kalhan R, Newman AB, O’Connor GT, Umans JG, White WB, Yende S, Oelsner EC. Low Lung Function Is Associated with High Population Attributable Fraction for Cardiovascular Mortality. Ann Am Thorac Soc. 2025;22(3):359-66. doi: 10.1513/AnnalsATS.202407-715OC. (PubMed PMID: 39447115; PMCID: PMC11892675).

Choi SH, Jurgens SJ, Xiao L, Hill MC, Haggerty CM, Sveinbjörnsson G, Morrill VN, Marston NA, Weng LC, Pirruccello JP, Arnar DO, Gudbjartsson DF, Mantineo H, von Falkenhausen AS, Natale A, Tveit A, Geelhoed B, Roselli C, Van Wagoner DR, Darbar D, Haase D, Soliman EZ, Davogustto GE, Jun G, Calkins H, Anderson JL, Brody JA, Halford JL, Barnard J, Hokanson JE, Smith JD, Bis JC, Young K, Johnson LSB, Risch L, Gula LJ, Kwee LC, Chaffin MD, Kühne M, Preuss M, Gupta N, Nafissi NA, Smith NL, Nilsson PM, van der Harst P, Wells QS, Judy RL, Schnabel RB, Johnson R, Smit RAJ, Gabriel S, Knight S, Furukawa T, Blackwell TW, Nauffal V, Wang X, Min YI, Yoneda ZT, Laksman ZWM, Bezzina CR, Alonso A, Psaty BM, Albert CM, Arking DE, Roden DM, Chasman DI, Rader DJ, Conen D, McManus DD, Fatkin D, Benjamin EJ, Boerwinkle E, Marcus GM, Christophersen IE, Smith JG, Roberts JD, Raffield LM, Shoemaker MB, Cho MH, Cutler MJ, Rienstra M, Chung MK, M SO, Sinner MF, Sotoodehnia N, Kirchhof P, Loos RJF, Nazarian S, Mohanty S, Damrauer SM, Kaab S, Heckbert SR, Redline S, Shah SH, Tanaka T, Ebana Y, Holm H, Stefansson K, Ruff CT, Sabatine MS, Lunetta KL, Lubitz SA, Ellinor PT. Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk. Nat Genet. 2025;57(3):548-62. Epub 20250306. doi: 10.1038/s41588-025-02074-9. (PubMed PMID: 40050430).

Hayes-Larson E, Andrews RM, Kezios KL, Bercu A, Rouanet A, Helmer C, Crane PK, Gibbons LE, Klinedinst BS, McEvoy LK, Nichols E, Weuve J, Rajan KB, Hwang PH, Mez J, Farina M, Shaw C, Sims KD, Therneau T, Petersen RC, Bouteloup V, Gross AL, Albert M, Morris JC, Masters CL, Resnick SM, Maruff P, Manly JJ, Turney IC, Vonk JMJ, Avila-Rieger J, Weigand A, Chen R, Wang J, Proust-Lima C, Mayeda ER. Approaches to Timescale Choice in Cognitive Aging Research and Potential Implications for Estimated Exposure Effects: Coordinated Analyses in 10 Cohorts of Older Adults. Epidemiology. 2025;36(4):560-71. Epub 20250331. doi: 10.1097/ede.0000000000001859. (PubMed PMID: 40164562; PMCID: PMC12211680).

Rehman H, Ang TFA, Tao Q, Au R, Farrer LA, Qiu WQ, Zhang X. Plasma protein risk scores for mild cognitive impairment and Alzheimer’s disease in the Framingham heart study. Alzheimers Dement. 2025;21(3):e70066. doi: 10.1002/alz.70066. (PubMed PMID: 40156298; PMCID: PMC11953566).

Roselli C, Surakka I, Olesen MS, Sveinbjornsson G, Marston NA, Choi SH, Holm H, Chaffin M, Gudbjartsson D, Hill MC, Aegisdottir H, Albert CM, Alonso A, Anderson CD, Arking DE, Arnar DO, Barnard J, Benjamin EJ, Braunwald E, Brumpton B, Campbell A, Chami N, Chasman DI, Cho K, Choi EK, Christophersen IE, Chung MK, Conen D, Crijns HJ, Cutler MJ, Czuba T, Damrauer SM, Dichgans M, Dörr M, Dudink E, Duong T, Erikstrup C, Esko T, Fatkin D, Faul JD, Ferreira M, Freitag DF, Ganesh SK, Gaziano JM, Geelhoed B, Ghouse J, Gieger C, Giulianini F, Graham SE, Gudnason V, Guo X, Haggerty C, Hayward C, Heckbert SR, Hveem K, Ito K, Johnson R, Jukema JW, Jurgens SJ, Kääb S, Kane JP, Kany S, Kardia SLR, Kavousi M, Khurshid S, Kamanu FK, Kirchhof P, Kleber ME, Knight S, Komuro I, Krieger JE, Launer LJ, Li D, Lin H, Lin HJ, Loos RJF, Lotta L, Lubitz SA, Lunetta KL, Macfarlane PW, Magnusson PKE, Malik R, Mantineo H, Marcus GM, März W, McManus DD, Melander O, Melloni GEM, Meyre PB, Miyazawa K, Mohanty S, Monfort LM, Müller-Nurasyid M, Nafissi NA, Natale A, Nazarian S, Ostrowski SR, Pak HN, Pang S, Pedersen OB, Pedersen NL, Pereira AC, Pirruccello JP, Preuss M, Psaty BM, Pullinger CR, Rader DJ, Rämö JT, Ridker PM, Rienstra M, Risch L, Roden DM, Rotter JI, Sabatine MS, Schunkert H, Shah SH, Shim J, Shoemaker MB, Simonson B, Sinner MF, Smit RAJ, Smith JA, Smith NL, Smith JG, Soliman EZ, Sørensen E, Sotoodehnia N, Strbian D, Stricker BH, Teder-Laving M, Sun YV, Thériault S, Thorolfsdottir RB, Thorsteinsdottir U, Tveit A, van der Harst P, van Meurs J, Wang B, Weiss S, Wells QS, Weng LC, Wilson PW, Xiao L, Yang PS, Yao J, Yoneda ZT, Zeller T, Zeng L, Zhao W, Zhou X, Zöllner S, Ruff CT, Bundgaard H, Willer C, Stefansson K, Ellinor PT. Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. Nat Genet. 2025;57(3):539-47. Epub 20250306. doi: 10.1038/s41588-024-02072-3. (PubMed PMID: 40050429; PMCID: PMC12094172).

Shubietah A, Awashra A, Milhem F, Ghannam M, Hattab M, Rajab I, Neiroukh H, Zahdeh M, Nouri A, Assaassa A, Nair K, Sahni A, Abu Rmilah A. Hyperuricemia and Cardiovascular Risk: Insights and Implications. Crit Pathw Cardiol. 2025. Epub 20250305. doi: 10.1097/hpc.0000000000000388. (PubMed PMID: 40062919).

Springer MV, Whitney RT, Ye W, Briceño EM, Gross AL, Aparicio HJ, Beiser AS, Burke JF, Elkind MSV, Ferber RA, Giordani B, Gottesman RF, Hayward RA, Howard VJ, Kollipara AS, Koton S, Lazar RM, Longstreth WT, Jr., Pendlebury ST, Sussman JB, Thacker EL, Levine DA. Education Levels and Poststroke Cognitive Trajectories. JAMA Netw Open. 2025;8(3):e252002. Epub 20250303. doi: 10.1001/jamanetworkopen.2025.2002. (PubMed PMID: 40136300; PMCID: PMC11947833).

Wang D, Scalici A, Wang Y, Lin H, Pitsillides A, Heard-Costa N, Cruchaga C, Ziegemeier E, Bis JC, Fornage M, Boerwinkle E, De Jager PL, Wijsman E, Dupuis J, Renton AE, Seshadri S, Goate AM, DeStefano AL, Peloso GM. Frequency of variants in Mendelian Alzheimer’s disease genes within the Alzheimer’s Disease Sequencing Project. J Alzheimers Dis. 2025;104(3):841-51. Epub 20250314. doi: 10.1177/13872877251320375. (PubMed PMID: 40084664).

Wu W, Zhu L, Zhang J, Li X, Yu D, Wang Y, Su Y, Wei X, Ma H, Song W, Li J, Teng L, Tang Q, Wu M. Gut metabolites and functional recovery after ischemic stroke: a genetic perspective. Mamm Genome. 2025;36(2):630-7. Epub 20250308. doi: 10.1007/s00335-025-10120-4. (PubMed PMID: 40056206).

Yang J, Ding H, Li Y, Ang TFA, Devine S, Liu Y, Qiu W, Au R, Ma J, Liu C. Association of mid-age Life’s Essential 8 score with digital cognitive performance and incident Alzheimer’s disease: The Framingham Heart Study. J Alzheimers Dis. 2025;104(2):498-508. Epub 20250302. doi: 10.1177/13872877251317734. (PubMed PMID: 40025717).

Yao Z, Tasdighi E, Dardari ZA, Jha KK, Osuji N, Rajan T, Boakye E, Rodriguez CJ, Matsushita K, Simonsick EM, Lima JAC, Widome R, Cohen DL, Appel LJ, Khera A, Hall ME, Judd SE, Cole SA, Vasan RS, Benjamin EJ, Lotufo PA, Benseñor IM, El Khoudary SR, Barinas-Mitchell E, Janssen I, Psaty BM, Eaton CB, LaMonte MJ, Cawthon PM, Orwoll ES, Irvin MR, Bhatnagar A, DeFilippis AP, El-Shahaway O, Blaha MJ. Association Between Cigarette Smoking and Subclinical Markers of Cardiovascular Harm. J Am Coll Cardiol. 2025;85(10):1018-34. doi: 10.1016/j.jacc.2024.12.032. (PubMed PMID: 40074467).

Yaqub A, Bis JC, Frenzel S, Koini M, Mbangdadji D, Peloso GM, Talluri R, Alonso A, Bahls M, Bülow R, Dörr M, Felix S, Fohner A, Friedrich N, Hofer E, Kavousi M, Launer LJ, Le T, Longstreth W, Mosley TH, Vernooij MW, Völzke H, Wittfeld K, Beiser AS, Grabe HJ, Gudnason V, Ikram MA, Psaty BM, Schmidt R, Simino J, Seshadri S, Wolters FJ. Clinical and Imaging Markers of Cardiac Function and Brain Health: A Meta-Analysis of Community-Based Studies. Neurology. 2025;104(8):e213421. Epub 20250326. doi: 10.1212/wnl.0000000000213421. (PubMed PMID: 40138616; PMCID: PMC11981472).

Zhang J, Hobbs BD, Silverman EK, Sparrow D, Ortega VE, Xu H, Zhang C, Dupuis J, Walkey AJ, O’Connor GT, Cho MH, Moll M. Polygenic Risk Score Added to Conventional Case Finding to Identify Undiagnosed Chronic Obstructive Pulmonary Disease. JAMA. 2025;333(9):784-92. doi: 10.1001/jama.2024.24212. (PubMed PMID: 39841442; PMCID: PMC11880956).

Zhang W, Young JI, Gomez L, Schmidt MA, Lukacsovich D, Kunkle BW, Chen XS, Martin ER, Wang L. Blood DNA methylation signature for incident dementia: Evidence from longitudinal cohorts. Alzheimers Dement. 2025;21(3):e14496. doi: 10.1002/alz.14496. (PubMed PMID: 40133250; PMCID: PMC11936765).

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April

Allaire BT, Johannesdottir F, Bouxsein ML, Anderson DE. Physiological and Anthropometric Factors Associated With Spine Loading Estimates From Imaging-Based Subject-Specific Musculoskeletal Models. JOR Spine. 2025;8(2):e70059. Epub 20250411. doi: 10.1002/jsp2.70059. (PubMed PMID: 40225046; PMCID: PMC11987705).

De Anda-Duran I, Hwang PH, Drabick DA, Andersen SL, Au R, Libon DJ. Neuropsychological phenotypic characteristics in a cohort of community-based older adults: Data from the Framingham Heart Study. J Alzheimers Dis. 2025;105(4):1447-59. Epub 20250423. doi: 10.1177/13872877251334608. (PubMed PMID: 40267270).

Ding H, Lyu C, Karjadi C, Sunderaraman P, Young CB, Mormino EC, Low S, Devine S, Gifford K, Au R, Lin H. Association of the digital clock drawing test with amyloid and tau PET biomarkers in low age risk adults. Sci Rep. 2025;15(1):11104. Epub 20250401. doi: 10.1038/s41598-025-95852-8. (PubMed PMID: 40169870; PMCID: PMC11961701).

Engelhard M, Wojdyla D, Wang H, Pencina M, Henao R. Exploring trade-offs in equitable stroke risk prediction with parity-constrained and race-free models. Artif Intell Med. 2025;164:103130. Epub 20250410. doi: 10.1016/j.artmed.2025.103130. (PubMed PMID: 40253926; PMCID: PMC12133243).

Grasset L, Bis JC, Frenzel S, Kojis D, Simino J, Yaqub A, Beiser A, Berr C, Bressler J, Bülow R, DeCarli CS, Fohner AE, Harrington LB, Helmer C, Ikram MA, Lemaitre RN, Lopez OL, Longstreth WT, Jr., Neitzel J, Odden MC, Palta P, Schmidt CO, Talluri R, Vernooij MW, Völzke H, Voortman T, Whalen Q, Wittfeld K, Grabe HJ, Mosley TH, Jr., Psaty BM, Wolters FJ, Seshadri S, Dufouil C. Selected social and lifestyle correlates of brain health markers: the Cross-Cohort Collaboration Consortium. Alzheimers Dement. 2025;21(4):e70148. doi: 10.1002/alz.70148. (PubMed PMID: 40207408; PMCID: PMC11982914).

Hoogeveen RC, Diffenderfer MR, Lim E, Liu CT, Ikezaki H, Guan W, Tsai MY, Ballantyne CM. Lipoprotein(a) and Risk of Incident Atherosclerotic Cardiovascular Disease: Impact of High-Sensitivity C-Reactive Protein and Risk Variability Among Human Clinical Subgroups. Nutrients. 2025;17(8). Epub 20250411. doi: 10.3390/nu17081324. (PubMed PMID: 40284189; PMCID: PMC12030245).

Kim H, Chen J, Prescott B, Walker ME, Grams ME, Yu B, Vasan RS, Floyd J, Sotoodehnia N, Smith NL, Arking DE, Coresh J, Rebholz CM. Plant-Based Diets and Cardiovascular Events: A Proteomics Approach to Examine the Underlying Pathways. J Nutr. 2025;155(6):1741-50. Epub 20250412. doi: 10.1016/j.tjnut.2025.04.011. (PubMed PMID: 40228715; PMCID: PMC12264535).

Libon DJ, Swenson R, Langford DT, Cosentino S, Price CC, Lamar M, Emrani S, Au R, Andersen S, Chen MH, Ashendorf L, Thompson L. Precision neurocognition: An emerging diagnostic paradigm leveraging digital cognitive assessment technology. J Alzheimers Dis. 2025:13872877251325725. Epub 20250422. doi: 10.1177/13872877251325725. (PubMed PMID: 40262110).

Lo J, Melhorn SJ, Kee S, Olerich KLW, Huang A, Yeum D, Beiser A, Seshadri S, DeCarli C, Schur EA. Hypothalamic Gliosis Is Associated With Multiple Cardiovascular Disease Risk Factors in the Framingham Heart Study. J Am Heart Assoc. 2025;14(10):e039463. Epub 20250416. doi: 10.1161/jaha.124.039463. (PubMed PMID: 40240914; PMCID: PMC12184564).

Manoharan MS, Lee GC, Harper N, Meunier JA, Restrepo MI, Jimenez F, Karekatt S, Branum AP, Gaitan AA, Andampour K, Smith AM, Mader M, Noronha M, Tripathy D, Zhang N, Moreira AG, Pandranki L, Sanchez-Reilly S, Trinh HD, Barnett C, Angel L, Segal LN, Nicholson S, Clark RA, He W, Okulicz JF, Ahuja SK. The 15-Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging. Aging cell. 2025;24(7):e70063. Epub 20250423. doi: 10.1111/acel.70063. (PubMed PMID: 40264357; PMCID: PMC12266754).

Nagarajan P, Winkler TW, Bentley AR, Miller CL, Kraja AT, Schwander K, Lee S, Wang W, Brown MR, Morrison JL, Giri A, O’Connell JR, Bartz TM, de Las Fuentes L, Gudmundsdottir V, Guo X, Harris SE, Huang Z, Kals M, Kho M, Lefevre C, Luan J, Lyytikäinen LP, Mangino M, Milaneschi Y, Palmer ND, Rao V, Rauramaa R, Shen B, Stadler S, Sun Q, Tang J, Thériault S, van der Graaf A, van der Most PJ, Wang Y, Weiss S, Westerman KE, Yang Q, Yasuharu T, Zhao W, Zhu W, Altschul D, Ansari MAY, Anugu P, Argoty-Pantoja AD, Arzt M, Aschard H, Attia JR, Bazzanno L, Breyer MA, Brody JA, Cade BE, Chen HH, Chen YI, Chen Z, de Vries PS, Dimitrov LM, Do A, Du J, Dupont CT, Edwards TL, Evans MK, Faquih T, Felix SB, Fisher-Hoch SP, Floyd JS, Graff M, Gu C, Gu D, Hairston KG, Hanley AJ, Heid IM, Heikkinen S, Highland HM, Hood MM, Kähönen M, Karvonen-Gutierrez CA, Kawaguchi T, Kazuya S, Kelly TN, Komulainen P, Levy D, Lin HJ, Liu PY, Marques-Vidal P, McCormick JB, Mei H, Meigs JB, Menni C, Nam K, Nolte IM, Pacheco NL, Petty LE, Polikowsky HG, Province MA, Psaty BM, Raffield LM, Raitakari OT, Rich SS, Riha RL, Risch L, Risch M, Ruiz-Narvaez EA, Scott RJ, Sitlani CM, Smith JA, Sofer T, Teder-Laving M, Völker U, Vollenweider P, Wang G, Willems van Dijk K, Wilson OD, Xia R, Yao J, Young KL, Zhang R, Zhu X, Below JE, Böger CA, Conen D, Cox SR, Dörr M, Feitosa MF, Fox ER, Franceschini N, Gharib SA, Gudnason V, Harlow SD, He J, Holliday EG, Kutalik Z, Lakka TA, Lawlor DA, Lee S, Lehtimäki T, Li C, Liu CT, Mägi R, Matsuda F, Morrison AC, Penninx BW, Peyser PA, Rotter JI, Snieder H, Spector TD, Wagenknecht LE, Wareham NJ, Zonderman AB, North KE, Fornage M, Hung AM, Manning AK, Gauderman J, Chen H, Munroe PB, Rao DC, van Heemst D, Redline S, Noordam R, Wang H. A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations. Mol Psychiatry. 2025;30(8):3660-72. Epub 20250404. doi: 10.1038/s41380-025-02954-w. (PubMed PMID: 40181193).

Pillai R, Zhang L, Peters K, Jha V, O’Donnell CJ, Manning WJ, Tsao CW. Age- and sex-differences and reference values for ventricular strain by cardiovascular magnetic resonance imaging in adults without cardiovascular disease or cardiovascular disease risk factors. J Cardiovasc Magn Reson. 2025;27(1):101902. Epub 20250427. doi: 10.1016/j.jocmr.2025.101902. (PubMed PMID: 40300666; PMCID: PMC12138549).

Salardini A, Himali JJ, Abdullah MS, Chaudhari R, Young V, Zilli EM, McGrath ER, Gonzales MM, Thibault EG, Salinas J, Aparicio HJ, Himali D, Ghosh S, Buckley RF, Satizabal CL, Johnson KA, DeCarli C, Fakhri GE, Vasan RS, Beiser AS, Seshadri S. Elevated serum cortisol associated with early-detected increase of brain amyloid deposition in Alzheimer’s disease imaging biomarkers among menopausal women: The Framingham Heart Study. Alzheimers Dement. 2025;21(4):e70179. doi: 10.1002/alz.70179. (PubMed PMID: 40271551; PMCID: PMC12019305).

Young VM, Bernal R, Baril AA, Zeynoun J, Wiedner C, Gaona C, Beiser A, Teixeira AL, Salardini A, Pase MP, Himali JJ, Seshadri S. Long sleep duration, cognitive performance, and the moderating role of depression: A cross-sectional analysis in the Framingham Heart Study. Alzheimers Dement. 2025;21(4):e70160. doi: 10.1002/alz.70160. (PubMed PMID: 40257009; PMCID: PMC12010301).

Zhang X, Brody JA, Graff M, Highland HM, Chami N, Xu H, Wang Z, Ferrier KR, Chittoor G, Josyula NS, Meyer M, Gupta S, Li X, Li Z, Allison MA, Becker DM, Bielak LF, Bis JC, Boorgula MP, Bowden DW, Broome JG, Buth EJ, Carlson CS, Chang KM, Chavan S, Chiu YF, Chuang LM, Conomos MP, DeMeo DL, Du M, Duggirala R, Eng C, Fohner AE, Freedman BI, Garrett ME, Guo X, Haiman C, Heavner BD, Hidalgo B, Hixson JE, Ho YL, Hobbs BD, Hu D, Hui Q, Hwu CM, Jackson RD, Jain D, Kalyani RR, Kardia SLR, Kelly TN, Lange EM, LeNoir M, Li C, Le Marchand L, McDonald MN, McHugh CP, Morrison AC, Naseri T, O’Connell J, O’Donnell CJ, Palmer ND, Pankow JS, Perry JA, Peters U, Preuss MH, Rao DC, Regan EA, Reupena SM, Roden DM, Rodriguez-Santana J, Sitlani CM, Smith JA, Tiwari HK, Vasan RS, Wang Z, Weeks DE, Wessel J, Wiggins KL, Wilkens LR, Wilson PWF, Yanek LR, Yoneda ZT, Zhao W, Zöllner S, Arnett DK, Ashley-Koch AE, Barnes KC, Blangero J, Boerwinkle E, Burchard EG, Carson AP, Chasman DI, Ida Chen YD, Curran JE, Fornage M, Gordeuk VR, He J, Heckbert SR, Hou L, Irvin MR, Kooperberg C, Minster RL, Mitchell BD, Nouraie M, Psaty BM, Raffield LM, Reiner AP, Rich SS, Rotter JI, Benjamin Shoemaker M, Smith NL, Taylor KD, Telen MJ, Weiss ST, Zhang Y, Heard-Costa N, Sun YV, Lin X, Cupples LA, Lange LA, Liu CT, Loos RJF, North KE, Justice AE. Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele. Nat Commun. 2025;16(1):3470. Epub 20250411. doi: 10.1038/s41467-025-58420-2. (PubMed PMID: 40216759; PMCID: PMC11992084).

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May

Aloraini GF, McKeown NM, Rogers GT, Das SK, Lichtenstein AH, Jacques PF. Low-Carbohydrate Diet Patterns That Favor High-Quality Carbohydrates Are Associated with Beneficial Long-Term Changes in Biomarkers of Inflammation and Oxidative Stress in the Framingham Offspring Cohort. Curr Dev Nutr. 2025;9(7):107479. Epub 20250528. doi: 10.1016/j.cdnut.2025.107479. (PubMed PMID: 40612047; PMCID: PMC12221638).

Cao Y, Salvati LR, Chen J, Ragab A, Mez J, Satizabal CL, Alosco ML, Fang Y, Qiu WQ, Lunetta KL, Murabito JM, Doyle MF. The Association of Circulating Immune Cells With Cognitive Function, Brain Imaging, and Incident All-cause and Alzheimer’s Dementia: The Framingham Offspring Study. J Gerontol A Biol Sci Med Sci. 2025;80(6). doi: 10.1093/gerona/glaf067. (PubMed PMID: 40168089; PMCID: PMC12128850).

Charisis S, Lu S, Melgarejo JD, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Association of Blood Lipoprotein Levels With Incident Alzheimer Disease in Community-Dwelling Individuals: The Framingham Heart Study. Neurology. 2025;104(12):e213715. Epub 20250530. doi: 10.1212/wnl.0000000000213715. (PubMed PMID: 40446198; PMCID: PMC12129701).

Collazo Martinez AD, Ting SJ, Shahidzadeh A, Vaidya B, Kowalczyk T, Alluwimi M, Rijal S, Jiang X, Wang R, Beiser A, Sobrin L, Seshadri S, Kashani AH. OCT Angiography-Derived Retinal Capillary Perfusion Measures in the Framingham Heart Study. Ophthalmol Sci. 2025;5(3):100696. Epub 20241227. doi: 10.1016/j.xops.2024.100696. (PubMed PMID: 40124307; PMCID: PMC11926700).

Kirmani S, Huan T, Van Amburg JC, Joehanes R, Uddin MM, Nguyen NQH, Yu B, Brody JA, Fornage M, Bressler J, Sotoodehnia N, Ong DA, Puddu F, Floyd JS, Ballantyne CM, Psaty BM, Raffield LM, Natarajan P, Conneely KN, Weinstock JS, Carson AP, Lange LA, Ferrier K, Heard-Costa NL, Murabito J, Bick AG, Levy D. Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation. Nat Commun. 2025;16(1):4678. Epub 20250520. doi: 10.1038/s41467-025-59333-w. (PubMed PMID: 40393957; PMCID: PMC12092741).

Leung YY, Lee WP, Kuzma AB, Nicaretta H, Valladares O, Gangadharan P, Qu L, Zhao Y, Ren Y, Cheng PL, Kuksa PP, Wang H, White H, Katanic Z, Bass L, Saravanan N, Greenfest-Allen E, Kirsch M, Cantwell L, Iqbal T, Wheeler NR, Farrell JJ, Zhu C, Turner SL, Gunasekaran TI, Mena PR, Jin Y, Carter L, Zhang X, Vardarajan BN, Toga A, Cuccaro M, Hohman TJ, Bush WS, Naj AC, Martin E, Dalgard CL, Kunkle BW, Farrer LA, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Wang LS. Alzheimer’s Disease Sequencing Project release 4 whole genome sequencing dataset. Alzheimers Dement. 2025;21(5):e70237. doi: 10.1002/alz.70237. (PubMed PMID: 40407102; PMCID: PMC12100500).

Lundin JI, Peters U, Hu Y, Ammous F, Benjamin EJ, Bis JC, Brody JA, Cushman M, Fuller H, Gignoux C, Guo X, Haessler J, Haiman C, Joehanes R, Kasela S, Kenny E, Lappalainen T, Levy D, Liu C, Liu Y, Loos RJF, Matise T, North KE, Park SL, Ratliff SM, Reiner A, Rich SS, Rotter JI, Smith JA, Sotoodehnia N, Tracy R, Van den Berg D, Ye T, Zhao W, Raffield LM, Kooperberg C. Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease. Atherosclerosis. 2025;407:120219. Epub 20250520. doi: 10.1016/j.atherosclerosis.2025.120219. (PubMed PMID: 40480020; PMCID: PMC12276907).

Nanna MG, Wojdyla D, Peterson ED, Navar AM, Williamson JD, Colantonio LD, Wang SY, Jamil Y, Bertoni AG, Nahid M, Damluji AA, Goyal P, Chaudhry SI, Gill TM, Alexander KP. Development and Validation of Models to Estimate the Incident Risk of Cognitive Impairment and Atherosclerotic Cardiovascular Disease in Older Adults. J Am Heart Assoc. 2025;14(11):e038949. Epub 20250522. doi: 10.1161/jaha.124.038949. (PubMed PMID: 40401627; PMCID: PMC12229195).

Nomura S, Guan W, Zhang Y, Tison GH, Ikezaki H, Diffenderfer MR, Liu CT, Hoogeveen RC, Ballantyne CM, Schaefer EJ, Tsai MY. Lipoprotein(a) and Heart Failure Among Black and White Participants in Atherosclerosis Risk in Communities Study, Framingham Offspring Study, and Multi-Ethnic Study of Atherosclerosis: The Pooling Project. J Am Heart Assoc. 2025;14(11):e038608. Epub 20250526. doi: 10.1161/jaha.124.038608. (PubMed PMID: 40417812; PMCID: PMC12229190).

Toro C, Daniels AS, Prescott B, Xanthakis V, Nayor M, Gajjar P, Benjamin EJ, Preis SR. Association of life’s essential 8 score with incidence of atrial fibrillation: The Framingham heart study. Am J Prev Cardiol. 2025;23:101018. Epub 20250531. doi: 10.1016/j.ajpc.2025.101018. (PubMed PMID: 40585337; PMCID: PMC12205587).

Truyen T, Lin H, Mathias M, Chugh H, Reinier K, Benjamin EJ, Chugh SS. Validation of a Novel Risk Prediction Score for Sudden Cardiac Death in the Framingham Heart Study. Circ Arrhythm Electrophysiol. 2025;18(6):e013647. Epub 20250520. doi: 10.1161/circep.124.013647. (PubMed PMID: 40391444; PMCID: PMC12173765).

Wang X, Larson MG, Liu C. Two-stage multiple imputation with a longitudinal composite variable. BMC Med Res Methodol. 2025;25(1):124. Epub 20250506. doi: 10.1186/s12874-025-02555-9. (PubMed PMID: 40329169; PMCID: PMC12054270).

Yiallourou S, Baril AA, Wiedner C, Misialek JR, Kline CE, Harrison S, Cannon E, Yang Q, Bernal R, Bisson A, Himali D, Cavuoto M, Weihs A, Beiser A, Gottesman RF, Leng Y, Lopez O, Lutsey PL, Purcell SM, Redline S, Seshadri S, Stone KL, Yaffe K, Ancoli-Israel S, Xiao Q, Vaou EO, Himali JJ, Pase MP. Sleep architecture and dementia risk in adults: An analysis of 5 cohorts from the Sleep and Dementia Consortium. Sleep. 2025. Epub 20250516. doi: 10.1093/sleep/zsaf129. (PubMed PMID: 40377976).

Zhou X, Yiannakou I, Yuan M, Singer MR, Moore LL. Associations of common fats and oils with cardiometabolic health outcomes in the Framingham Offspring cohort. Eur J Clin Nutr. 2025. Epub 20250522. doi: 10.1038/s41430-025-01601-5. (PubMed PMID: 40404978).

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June

Almidani L, Sabharwal J, Shahidzadeh A, Martinez AC, Ting SJ, Vaidya B, Jiang X, Kowalczyk T, Beiser A, Sobrin L, Seshadri S, Ramulu P, Kashani AH. Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study. Transl Vis Sci Technol. 2025;14(6):7. doi: 10.1167/tvst.14.6.7. (PubMed PMID: 40459525; PMCID: PMC12136102).

Buckley RF, Scott M, McGrath ER, Coughlan G, Seto M, Ghosh S, Jacobs HIL, Satizabal CL, Thibault E, Ramachandran V, Murabito JM, Sperling RA, Johnson KA, Jasuja R, Bhasin S, Seshadri S, Beiser AS. Midlife Steroid-Binding Globulin Levels and In Vivo Neuroimaging Measures of Tau in Older Men and Women. Ann Neurol. 2025. Epub 20250614. doi: 10.1002/ana.27266. (PubMed PMID: 40515488).

Chen H, Ding Y, Dhana K, Agarwal P, Beck T, Rajan KB, Melo van Lent D, Ma Y, Zong G, Bjornevik K, Yuan C. Sweetened Beverages and Incident All-Cause Dementia Among Older Adults. JAMA Psychiatry. 2025. Epub 20250618. doi: 10.1001/jamapsychiatry.2025.1230. (PubMed PMID: 40531522; PMCID: PMC12177730).

Fang Y, Chen J, Mez J, Satizabal CL, Alosco ML, Qiu WQ, Doyle MF, Murabito JM, Lunetta KL. Modeling heterogeneity in cognitive trajectories in the Framingham Heart Study. Front Aging Neurosci. 2025;17:1471154. Epub 20250625. doi: 10.3389/fnagi.2025.1471154. (PubMed PMID: 40636900; PMCID: PMC12238755).

Fuentealba M, Rouch L, Guyonnet S, Lemaitre JM, de Souto Barreto P, Vellas B, Andrieu S, Furman D. A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors. Nat Aging. 2025;5(7):1207-16. Epub 20250604. doi: 10.1038/s43587-025-00883-5. (PubMed PMID: 40467932; PMCID: PMC12270914).

Guan CK, Gu ZB, Sun JY, Zhu WG, Ye M. Relationship between TyG trajectories and Alzheimer’s disease: data from the Framingham Heart Study. Rev Clin Esp (Barc). 2025:502331. Epub 20250613. doi: 10.1016/j.rceng.2025.502331. (PubMed PMID: 40517811).

Kashani AH, Berendschot T, Bonnin S, Sobrin L, De Jesus DA, Brea LS, Martinez AC, Raman R, de Vries VA, Huang H, MacGillivray T, Ramdas WD, van der Heide FCT. Retinal optical coherence tomography angiography imaging in population studies for study of microvascular dysfunction in Alzheimer’s disease and related dementias. Alzheimers Dement. 2025;21(6):e70252. doi: 10.1002/alz.70252. (PubMed PMID: 40457754; PMCID: PMC12130554).

Kozlova D, Gimblet C, Wendt L, Akbari S, Taiwo A, Dayal S, Ten Eyck P, Stanhewicz A, Trinity J, Jalal D. Vascular dysfunction is associated with major adverse cardiovascular events in prediabetes: A cohort study. PloS One. 2025;20(6):e0324945. Epub 20250605. doi: 10.1371/journal.pone.0324945. (PubMed PMID: 40471971; PMCID: PMC12140275).

Kurniansyah N, Strausz SJ, Chittoor G, Gupta S, Justice AE, Hrytsenko Y, Keenan BT, Cade BE, Spitzer BW, Wang H, Huffman J, Moll MR, Haring B, Jung SY, Raffield LM, Kaplan R, Rotter JI, Rich SS, Gharib SA, Bartz TM, Liu PY, Chen H, Fornage M, Hou L, Levy D, Morrison AC, Ochs-Balcom HM, Psaty BM, Wilson PWF, Cho K, Pack AI, Ollila HM, Redline S, Gottlieb DJ, Sofer T. Polygenic scores for obstructive sleep apnoea reveal pathways contributing to cardiovascular disease. EBioMedicine. 2025;117:105790. Epub 20250604. doi: 10.1016/j.ebiom.2025.105790. (PubMed PMID: 40472801; PMCID: PMC12171572).

Kuzma A, Valladares O, Greenfest-Allen E, Nicaretta H, Kirsch M, Ren Y, Katanic Z, White H, Wilk A, Bass L, Brettschneider J, Carter L, Cifello J, Chuang WH, Clark K, Gangadharan P, Haut J, Ho PC, Horng W, Iqbal T, Jin Y, Keskinen P, Rose AL, Moon MK, Manuel J, Qu L, Robbins F, Saravanan N, Sha J, Tate S, Zhao Y, Cantwell L, Gardner J, Chou SY, Tzeng JY, Bush W, Naj A, Kuksa P, Lee WP, Leung YY, Schellenberg G, Wang LS. NIAGADS: A data repository for Alzheimer’s disease and related dementia genomics. Alzheimers Dement. 2025;21(6):e70255. doi: 10.1002/alz.70255. (PubMed PMID: 40545618; PMCID: PMC12183107).

Lai HTM, Ryder NA, Tintle NL, Jackson KH, Kris-Etherton PM, Harris WS. Red Blood Cell Omega-6 Fatty Acids and Biomarkers of Inflammation in the Framingham Offspring Study. Nutrients. 2025;17(13). Epub 20250622. doi: 10.3390/nu17132076. (PubMed PMID: 40647182; PMCID: PMC12251348).

Nicolas A, Sherva R, Grenier-Boley B, Kim Y, Kikuchi M, Timsina J, de Rojas I, Dalmasso MC, Zhou X, Le Guen Y, Arboleda-Bustos CE, Camargos Bicalho MA, Guerchet M, van der Lee S, Goss M, Castillo A, Bellenguez C, Küçükali F, Satizabal CL, Fongang B, Yang Q, Peters O, Schneider A, Dichgans M, Rujescu D, Scherbaum N, Deckert J, Riedel-Heller S, Hausner L, Molina-Porcel L, Düzel E, Grimmer T, Wiltfang J, Heilmann-Heimbach S, Moebus S, Tegos T, Scarmeas N, Dols-Icardo O, Moreno F, Pérez-Tur J, Bullido MJ, Pastor P, Sánchez-Valle R, Álvarez V, Cao H, Ip NY, Fu AKY, Ip FCF, Olivar N, Muchnik C, Cuesta C, Campanelli L, Solis P, Politis DG, Kochen S, Brusco LI, Boada M, García-González P, Puerta R, Mir P, Real LM, Piñol-Ripoll G, García-Alberca JM, Royo JL, Rodriguez-Rodriguez E, Soininen H, Heikkinen S, de Mendonça A, Mehrabian S, Traykov L, Hort J, Vyhnalek M, Rasmussen KL, Thomassen JQ, Pijnenburg YAL, Holstege H, van Swieten JC, Seelaar H, Claassen J, Jansen WJ, Ramakers I, Verhey F, van der Lugt A, Scheltens P, Ortega-Rojas J, Concha Mera AG, Mahecha MF, Pardo R, Arboleda G, Bahrami S, Fominykh V, Selbæk G, Graff C, Papenberg G, Giedraitis V, Boland A, Deleuze JF, de Marco LA, de Moraes EN, de Mattos Viana B, Túlio Gualberto Cintra M, Juarez-Cedillo T, Griswold AJ, Forund T, Haines J, Farrer L, DeStefano A, Wijsman E, Mayeux R, Pericak-Vance M, Kunkle B, Goate A, Schellenberg GD, Vardarajan B, Wang LS, Leung YY, Dalgard CL, Nicolas G, Wallon D, Dufouil C, Pasquier F, Hanon O, Debette S, Grünblatt E, Popp J, Angel B, Gloger S, Chacon MV, Aranguiz R, Orellana P, Slachevsky A, Gonzalez-Billault C, Albala C, Fuentes P, Sachdev P, Mather KA, Hauger RL, Merritt V, Panizzon M, Zhang R, Gaziano JM, Ghidoni R, Galimberti D, Arosio B, Mecocci P, Solfrizzi V, Parnetti L, Squassina A, Tremolizzo L, Borroni B, Nacmias B, Caffarra P, Seripa D, Rainero I, Daniele A, Piras F, Leonard HL, Yokoyama JS, Nalls MA, Miyashita A, Hara N, Ozaki K, Niida S, Williams J, Masullo C, Amouyel P, Preux PM, Mbelesso P, Bandzouzi B, Saykin A, Jessen F, Kehoe PG, Van Duijn C, Ben Salem N, Frikke-Schmidt R, Cherni L, Greicius MD, Tsolaki M, Sánchez-Juan P, Romano Silva MA, Porter T, Laws SM, Sleegers K, Ingelsson M, Dartigues JF, Seshadri S, Rossi G, Morelli L, Hiltunen M, Sims R, van der Flier W, Andreassen OA, Arboleda H, Cruchaga C, Escott-Price V, Ruiz A, Lee KH, Ikeuchi T, Ramirez A, Gim J, Logue M, Lambert JC. Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations. Nat Genet. 2025;57(7):1598-610. Epub 20250618. doi: 10.1038/s41588-025-02227-w. (PubMed PMID: 40533518; PMCID: PMC12283339).

Niroumandi S, Wei H, Amlani F, Gorji H, Alavi R, Chirinos JA, Pahlevan NM. Time-frequency machine learning transfer function for central pressure waveforms. Eur Heart J Open. 2025;5(4):oeaf082. Epub 20250623. doi: 10.1093/ehjopen/oeaf082. (PubMed PMID: 40718398; PMCID: PMC12290398).

Rizvi N, Lin H, Beiser AS, Spartano NL. How Do Occupational Sedentary Behavior and Occupational Cognitive Complexity Relate to Cognitive Function? A Cross-Sectional Study. Health Sci Rep. 2025;8(6):e70949. Epub 20250620. doi: 10.1002/hsr2.70949. (PubMed PMID: 40547068; PMCID: PMC12180288).

Toro AR, Lara FR, Pinheiro A, Demissie S, Decarli C, Parva P, Habes M, Charidimou A, Seshadri S, Maillard P, Romero JR. Association of MRI visible Perivascular Spaces with Early White Matter Injury. AJNR Am J Neuroradiol. 2025. Epub 20250603. doi: 10.3174/ajnr.A8823. (PubMed PMID: 40461258).

Wang X, Zhang Y, Pathiravasan CH, Spartano NL, Benjamin EJ, McManus DD, Lewis GD, Larson MG, Vasan RS, Murabito JM, Liu C, Nayor M. Blood Pressure Responses During Exercise Were Associated With Average Home Blood Pressure and Home Blood Pressure Variability: The Electronic Framingham Heart Study. J Am Heart Assoc. 2025;14(11):e039457. Epub 20250603. doi: 10.1161/jaha.124.039457. (PubMed PMID: 40459124; PMCID: PMC12229214).

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